Use of galvanostatic coulometry for determining nitroxoline

It was found that nitroxoline rapidly and quantitatively reacts with electrogenerated chlorine or bromine. The stoichiometric coefficients of these reactions are 1: 1.5 and 1: 1, respectively. The mechanism of the reaction of nitroxoline with electrogenerated bromine was proposed. A procedure was developed for the quantitative determination of nitroxoline in the substance and pharmaceuticals with a relative standard deviation of 1-3%. © 2007 Pleiades Publishing, Ltd

Quantitative estimation of benzylisoquinoline derivatives by coulometric titration

A method for estimating papaverine HCl and drotaverine HCl by coulometric titration with biamperometric indication of the end point was developed. The stoichiometric coefficients of the reactions of papaverine and drotaverine with electrogenerated chlorine were determined. Microgram quantities of agents in substance and therapeutic forms were estimated with a relative standard deviation (RSD) of 0.01-0.03. © 2008 Springer Science+Business Media, Inc

Impact of landed property transformation on reproductive process in the agrarian process of regions

The article presents the results on land ownership transformation and its impact on the reproductive process in the agricultural sector of the Volga Region Federal District in conditions of the existing model. The analysis of the consequences of the land reform, of which 115,4 million hectares of agricultural lands were transferred into common share ownership in the form of land shares without defining the boundaries on the ground, was carried out. Availability of land shares which are not transformed into the land, fouls up and causes chaos and uncertainty in land relations, leading to the criminalization of the land market, speculative land transactions, hinders the development of the land turnover. The position of the Volga Region Federal District and its individual regions in regard to the national indexes that characterize agricultural production, factors of reproduction, is established. The conclusion concerning the low level of production profitability is made, and it hampers the extended reproduction and, consequently, the high demand for land for agricultural purposes in the future.peer-reviewe

Use of galvanostatic coulometry in the analysis of arbidol drug

Arbidol is proved to easily and completely react with electrogenerated bromine in the ratio 2: 9; so procedures for the arbidol quantification in the neat substance and drugs are developed, the RSD value does not exceed 2%. A procedure for the coulometric determination of water in the arbidol substance using the Fisher method is proposed. © 2012 Pleiades Publishing, Ltd

The Effect of Personal Health on the Formation of Human Capital: a Metasystem Approach

In article the problem of influence of the personality's health on formation of the human capital is considered. Authors have conducted theoretical researches of the existing knowledge of the human capital and justifications of influence of the personality's health on its formation are given. On the basis of the carried-out analysis it is established that now the personality's health is a significant factor of efficiency of any kind of activity and important quality of the personality, therefore, it can be considered as a factor of formation of the human capital. According to it need of determination of criteria, the indicators of health of the personality influencing formation and development of the human capital was designated

The role of the quality production process of the business entitles in volatile environment

© 2015, Canadian Center of Science and Education. All rights reserved. The purpose of the article is to develop the conditions to improve innovation activity of the business entities and find the source of the macroeconomic dynamics. The presented article determines coordination between the positions of general and strategic management in the field of total quality management of a business entity to achieve continuous improvement in all areas of business. The foundation of the submitted work serves the idea of total quality management spread over the strategic planning inside a business structure in terms of institutional transformation of the national economy. This article describes the effects of the company’s financial improvement resulting from implementation of the quality tools into the strategic planning system of the industrial business structures. The article is intended for chief managers, executives, researchers dealing with quality management and strategic planning of the business structures

Thermally induced diphenylalanine cyclization in solid phase

© 2016, Akadémiai Kiadó, Budapest, Hungary.The reaction of cyclization of diphenylalanine in solid phase under heating was studied, which is a stage in formation of various nanostructures from this dipeptide. The temperature ranges of the reaction as well as of dehydration of clathrate of diphenylalanine with water were determined. Kinetic parameters of cyclization were estimated within the approaches of the non-isothermal kinetics (“model-free” kinetics and linear regression methods for detection of topochemical equation). The product of diphenylalanine cyclization was characterized by X-ray powder diffractometry, FTIR spectroscopy and TG/DSC analysis. Crystallization of diphenylalanine and cyclo(diphenylalanine) from methanol solutions was studied using atomic force microscopy. The results obtained may be useful for the design of new nanomaterials based on diphenylalanine at high temperatures

Dynamic Strength of Submicrocrystalline Copper and Copper Alloys Obtained by High-Speed Pressing

The mechanical properties of copper with a purity of 99,8 wt. % and alloys Cu–0,03 wt. %Zr and Cu–0,1wt. %Cr with submicrocrystalline structure obtained by dynamic channel-angular pressing was studied. The tests were carried out under shock-wave compression with pressure up to 7 GPа and strain rate 10 5 s–1.Исследованы механические свойства меди чистотой 99,8 мас. % и сплавов Cu–0,03 мас. %Zr и Cu–0,1 мас. %Cr с субмикрокристаллической структурой, полученной методом динамического канально-углового прессования. Испытания проводились в условиях ударного сжатия с давлением до 7 ГПа и скоростью деформации 10 5 с–1.Работа выполнена в рамках государственного задания по теме «Структура» № АААА-А18-118020190116-6 и Программе Президиума РАН «Конденсированное вещество и плазма при высоких плотностях энергии»

Влияние циклопролилглицина и его аналогов на моноаминергические системы мозга мышей BALB/c

Effects of chronic cycloprolylglycine (CPG) and its analogues GZK-001 and GZK-002 treatment at the doses 1 and 2 mg/kg on levels of monoamines and their metabolites in BALB/c mice brain were determined by HPLC. Neurochemical data demonstrated that antidepressant-like effects of the peptides are mediated by an increase in NA and decrease in DA content in frontal cortex. Alterations in striatal monoamine metabolism were observed predominantly after CPG's analogues treatment: the concentration of DA was increased, although its rate of turnover was diminished. In hippocampus more active was CPG: the levels of NE, DA, 5-HT, and its metabolite 5-HIAA were decreased. GZK-001 (1 mg/kg) caused a decrease in the concentration of DA and 5-HIAA. The present results suggest that antidepressant-like effects of CPG and its analogues are associated with DA, NE, and 5-HT systems.Методом ВЭЖХ изучено влияние хронического введения циклопролилглицина (ЦПГ) и его аналогов ГЗК-001 и ГЗК-002 в дозах 1 и 2 мг/кг на содержание и метаболизм (5-HT), дофамина (ДА) и норадреналина (НА) в структурах мозга мышей BALB/c. Было показано, что антидепрессивноподобное действие пептидов сопровождается увеличением уровня НА и уменьшением содержания ДА во фронтальной коре. В стриатуме преобладало влияние аналогов ЦПГ: увеличивался уровень ДА и снижалась скорость его метаболизма. В гиппокампе напротив активнее был ЦПГ: уменьшалось содержание НА, ДА, 5-НТ и его метаболита 5-ГИУК. Под влиянием ГЗК-001 в дозе 1 мг снижался уровень ДА и 5-ГИУК. На основании полученных данных можно заключить, что в механизме антидепрессивноподобного эффекта ЦПГ и его аналогов принимают участие серотонинергическая, норадреналинергическая и дофаминергическая системы мозга

Изучение фармакокинетики [3Н]-циклопролилглицина в крови крыс

Resume. The objective of this study is to evaluate pharmacokinetic parameters of tritium-labeled cycloprolylglycine [3H] -CPG following intravenous bolus administration of 5.7 μg (2 mCi). [3H] -CPG was prepared by solid-state catalytic isotopic exchange with spillover-tritium. It was found that plasma concentration-time profile of [3H] -CPG is adequately fit by a two-compartment model. The pharmacokinetic parameter estimates revealed rapid а-phase (distribution phase) (T1/2α min) followed by a slower β-phase of elimination (T1/2β 80 min). These findings are consistent with previous results of pharmacokinetic study of CPG as a noopept metabolite. CPG is differ significantly from other therapeutic peptides in pharmacokinetic profile (T1/2 , MRT, etc), which implies that CPG has a more prolonged duration of action.Изучена фармакокинетика меченого по тритию метаболита ноопепта циклопролилглицина [3Н]-ЦПГ после внутривенного болюсного введения в дозе 5,7 мкг (2 мКи). Мечение субстанции ЦПГ проводили с помощью реакции высокотемпературного твердофазного каталитического изотопного обмена. Обнаружено, что временной характер изменений концентрации [3Н]-ЦПГ в крови крыс подчиняется двухкамерной модели. Расчёт фармакокинетических параметров показал, что α-фаза (фаза распределения) протекает очень быстро, а β-фаза элиминации [3Н]-ЦПГ достаточно продолжительна. При этом величина Т1/2α составляет 1 мин, а Т1/2β - 80 мин. Эти данные согласуются с ранее полученными результатами по фармакокинетике ЦПГ как метаболита, образующегося из лекарственного препарата ноопепт. ЦПГ существенно отличается от других дипептидных соединений по величинам фармакокинетических параметров (Т1/2e , MRT и др.), что предполагает наличие у него большей продолжительности фармакологического действия