NOVEL ANTICOAGULANTS BEYOND HEPARIN AND WARFARIN

Objective: The objective of the study is to know about newer anticoagulant drugs.Method: The Vitamin K adversaries are the single type of oral anticoagulant in the pharmaceutical, and which is endorsed for long-haul utilize.What is more, the Vitamin K adversaries are exceedingly successful, so it is utilized to avert, and treatment of most thrombotic infections in patients,the noteworthy interpatient and intrapatient are additionally fluctuation in measurement response, and the thin restorative medication record andthe more quantities of medication and dietary communications related with these specialists have lead clinicians, patients, and examiners to scanfor different operators. The three new orally controlled anticoagulants are apixaban, dabigatran, and rivaroxaban, which are in the late periods ofprogression and a couple of others they are basically entering (or traveling through), the earlier times of examinations. Those most recent anticoagulantdrugs are being contemplated just for the avoidance and furthermore the treatment of venous for the thromboembolism, and the treatment of intensecoronary conduit disorders, and furthermore the counteractive action of stroke in patients influenced by atrial fibrillation.Results: The pharmacological action of the three new orally controlled anticoagulants is apixaban, dabigatran, and rivaroxaban completely reviewedand compared with warfarin.Conclusion: We are compared the newer anticoagulant with warfarin and discussed about advantages of newer anticoagulants

Optical and structure Characteristics of diamond like-carbon thin films produced by PLD.

تم استخدام ليزرND: YAG الطول الموجي ١٠٦٤ نانومتر  في الترسيب بالليزر النبضي  PLD لتكوين غشاء الماس شبيه الكاربون DLC على اساس زجاجي في درجة حرارة الغرفة. التركيب ومورفولوجيا السطح بالفحص بمجهر القوى الذرية  AFM لدراسة الغشاء  وتحويل فورييه لأطياف الأشعة تحت الحمراء FTIR للماس شبيه الكاربون DLC المستخدمة لمعرفة وجود الروابط وكذلك خصائص المجهر الالكتروني الماسح SEM وتشتيت الطاقة بالأشعة السينية EDX . يحتوي غشاء الماس شبيه الكاربون DLC المرسب على بنية مدمجة من الحبيبات المتراصة ويحتوي الغشاء على جسيمات غير منتظمة الشكل ( عناقيد) منDLC واكدت أطياف FTIR ان غشاء DLCيحتوي على ذرات كاربون مع تهجينsp3  وتم التحقيق في الخواص البصرية مع النتائج المتعلقة مثل النفاذية ومعامل الامتصاص وفجوة الطاقة البصرية والانعكاس R ومعامل الخمودKومعامل الانكسارn .     The utilizing of Nd: YAG laser (wave length-1064 nm) in the pulsed laser-deposition-PLD for placing diamond-like carbon DLC-film on glass substratum at the normal temperature of room. The composition and morphology of the surface for the atomic force microscopy (AFM), synthesized film and Fourier transform infrared FTIR-spectra for DLC utilized to know the presence of bonding were characterized by scanning electron microscopy-SEM and energy dispersive x-ray -EDX. Deposited DLC-film has a compact structure of dense grains, and the film contained irregular shape particles (clusters) of DLC. FTIR-spectra confirmed that the DLC-film contains carbon atoms with sp3-hybridization.Were investigated in optical properties with the results concerning the transmittance, absorption coefficient-(α), optical energy-gap, reflectance-R, extinction coefficient-k and refractive index-n

New modification on feistel DES algorithm based on multi-level keys

The data encryption standard (DES) is one of the most common symmetric encryption algorithms, but it experiences many problems. For example, it uses only one function (XOR) in the encryption process, and the combination of data is finite because it occurs only twice and operates on bits. This paper presents a new modification of the DES to overcome these problems. This could be done through adding a new level of security by increasing the key space (using three keys) during the 16 rounds of the standard encryption algorithm and by replacing the predefined XOR operation with a new # operation. Our proposed algorithm uses three keys instead of one. The first key is the input key used for encrypting and decrypting operations. The second key is used for determining the number of bits, while the third key is used for determining the table numbers, which are from 0 to 255. Having evaluated the complexity of our proposed algorithm, the results show that it is the most complex compared with the well-known DES and other modified algorithms. Consequently, in our proposed algorithm, the attacker try a number of attempts 21173 at minimum to decrypt the message. This means that the proposed DES algorithm will increase the security level of the well-known DES

A new multi-level key block cypher based on the Blowfish algorithm

Blowfish is a block cypher algorithm used in many applications to enhance security, but it includes several drawbacks. For example, the mix between the key and data is limited. This paper presents a new modification to the Blowfish algorithm to overcome such problems realised through a multi-state operation instead of an XOR. Our proposed algorithm uses three keys in the encryption and decryption processes instead of one for controlling the variable block bits sizes (1, 2, 4, and 8) bits and for determining the state table numbers. These tables are formed from the addition in a Galois field GF (2n) based on block bit size to increase the complexity of the proposed algorithm. Results are evaluated based on the criteria of complexity, time encryption, throughout, and histogram, and show that the original Blowfish, those modified by other scholars, and our proposed algorithm are similar in time computation. Our algorithm is demonstrated to be the most complex compared with other well-known and modified algorithms. This increased complexity score for our proposed Blowfish makes it more resistant against attempts to break the keys

Awareness of medical students towards cancer

Background: Cancer is the second leading cause of mortality worldwide. Amongst the cancers, the three leading cancers in India which causes high mortality and morbidity includes cervical cancer, breast cancer and upper aerodigestive tract carcinoma. High mortality and morbidity due to cancers can be reduced by preventive measures and early diagnosis of cancer, which can be achieved by creating awareness.Methods: A total of 337 medical students from 1st year to 4th year (1st year students-preclinical, 2nd year students-paraclinical and 3rd and 4th year students- clinical students) were included in this study and the results were analysed by descriptive statistics, Pearson’s Chi square test and paired ‘t’ test.Results: Out of 337 students, 120 were males, 204 were females and 13 students have not mentioned their gender. There was significant difference in knowledge of the students between pretest and posttest (following a short lecture) and amongst the preclinical, paraclinical and clinical students. Clinical students were found be more aware about the cancer compared to the preclinical and paraclinical students.Conclusions: Creating awareness to the medical students who are future doctors is the need of the hour. A short talk on cancer awareness can create a great impact on the awareness

Quality of Reporting in Preclinical Urethral Tissue Engineering Studies:A Systematic Review to Assess Adherence to the ARRIVE Guidelines

SIMPLE SUMMARY: We have conducted a systematic review to investigate the quality of reporting in preclinical experiments exploring tissue engineering approaches for urethral repair. This was performed based on the Animal Research: Reporting of In Vivo Experiments (ARRIVE) guidelines in a total of 28 articles from 2014 to 2020. Inadequate reporting of the essential points of research experiments was observed that could remarkably affect clarity, reproducibility, and translatability. A complete statement of the ethical review permission and guidelines followed was missing in 54% of the studies. Details to ensure reproducibility of the studies, such as animal housing, husbandry, and anesthetics, were infrequently reported. No paper stated the sample size estimation methodology. The quality of reporting improved marginally over the study period. We encourage the utilization of the ARRIVE checklist items when reporting preclinical studies to help the publication of manuscripts that would allow a precise judgment of their scientific merit. ABSTRACT: Preclinical research within the area of urethral tissue engineering has not yet been successfully translated into an efficient therapeutic option for patients. This gap could be attributed, in part, to inadequate design and reporting of the studies employing laboratory animals. In this study, a systematic review was conducted to investigate the quality of reporting in preclinical studies utilizing tissue engineering approaches for urethral repair. The scope was on studies performed in rabbits, published between January 2014 and March 2020. Quality assessment of the data was conducted according to the Animal Research: Reporting of in Vivo Experiments (ARRIVE) guidelines by the scoring of a 38-item checklist in different categories. A total of 28 articles that fulfilled the eligibility criteria were included in the study. The range of ARRIVE score was from 0 to 100, taking into consideration having reported the item in question or not. The mean checklist score was 53%. The items that attained the highest scores included the number of animals utilized, the size of control and experimental groups, and the definition of experimental outcomes. The least frequently reported items included the data regarding the experimental procedure, housing and husbandry, determination and justification of the number of animals, and reporting of adverse events. Surprisingly, full disclosure about ethical guidelines and animal protocol approval was missing in 54% of the studies. No paper stated the sample size estimation. Overall, our study found that a large number of studies display inadequate reporting of fundamental information and that the quality of reporting improved marginally over the study period. We encourage a comprehensive implementation of the ARRIVE guidelines in animal studies exploring tissue engineering for urethral repair, not only to facilitate effective translation of preclinical research findings into clinical therapies, but also to ensure compliance with ethical principles and to minimize unnecessary animal studies

Iraqi refugees in Egypt: an exploration of their mental health and psychosocial status

Thousands of Iraqis have settled in Egypt since 2003, escaping death threats, torture, kidnappings and military attacks to face uncertainty in their lives and increasing strain on the psychosocial challenges in their new lives. This explorative study describes the psychosocial stress faced by these Iraqi refugees in Egypt. Two hundred and four Iraqis in Egypt ¢lled in a checklist focussing on four groups of stress factors.The data provided by this study demonstrate the contribution of violence to Iraqi refugees'life from a number of sources. More than 56% have experienced multiple traumatic situations before immigration and the refugees themselves report major impacts on their health, mental health and socioeconomic demands. A motivated desire to return home was preferred by only one third of respondents

Prediction of Square Footing Settlement under Eccentric Loading on Gypseous Soil through Proposed Surface for Dry and Soaked States

Gypseous soils as any other soils deform under loading, this deformation differs greatly between its dry state and its soaked state. This deformation also differs when the loading is applied with eccentricity.An experimental work was conducted on a square footing model (100 mm 100 mm) above gypseous soil 450 mm thick. Loading was applied at the center of the footing (e/B = 0) and at an eccentricity of (e/B = 0.05, 0.1, 0.15, 0.2) for its dry state and its soaked state. Settlement was obtained at the center and at the base soil of the footing for each state.The data obtained was normalized and a proposed surface was obtained for each of the two states (dry and soaked) and at two places (center and edge). Four proposed equations were obtained represented four cases of research i) Dry center, ii) Dry edge, iii) Soaked center, and iv) Soaked edge. The four equations showed very good agreement with the data obtained from the experiment.Artificial Neural Network model was also used to obtain a neural network representing the proposed surface for the abovementioned four cases and also a very good agreement was obtained.It is concluded that a proposed surface for the central and eccentric loading on square footing for gypseous soil showed a good agreement with the experimental data and therefore may be used for settlement prediction

Perioperative donor bone marrow infusion augments chimerism in heart and lung transplant recipients

Background.: We and others have demonstrated that a low level of donor cell chimerism was present for years after transplantation in tissues and peripheral blood of heart and lung recipients; it was associated, in the latter, with a lower incidence of chronic rejection. To augment this phenomenon, we initiated a trial combining simultaneous infusion of donor bone marrow with heart or lung allotransplantation. Methods.: Between September 1993 and January 1995, 15 nonconditioned patients received either heart (n = 10) or lung (n = 5) allografts concurrently with an infusion of unmodified donor bone marrow (3.0 × 108 cells/kg), and were maintained on an immunosuppressive regimen consisting of tacrolimus and steroids. Results.: There was no complication associated with the infusion of donor bone marrow. Chimerism was detectable in 73% of bone marrow-augmented patients up to the last sample tested. Of the 5 control recipients who did not receive bone marrow infusion, only 1 had detectable chimerism by flow on postoperative day 15, which dwindled to an undetectable level by postoperative day 36. None of the patients had evidence of donor-specific immune modulation by mixed lymphocyte reaction. Conclusions.: The combined infusion of donor bone marrow and heart or lung transplantation, without preconditioning of the recipient, is safe and is associated with an augmentation of donor cell chimerism. © 1995 The Society of Thoracic Surgeons