Non-hyperbolic ergodic measures with large support

We prove that there is a residual subset $\mathcal{S}$ in $\text{Diff}^1(M)$ such that, for every $f\in \mathcal{S}$, any homoclinic class of $f$ with invariant one dimensional central bundle containing saddles of different indices (i.e. with different dimensions of the stable invariant manifold) coincides with the support of some invariant ergodic non-hyperbolic (one of the Lyapunov exponents is equal to zero) measure of $f$

Lipschitz shadowing implies structural stability

We show that the Lipschitz shadowing property of a diffeomorphism is equivalent to structural stability. As a corollary, we show that an expansive diffeomorphism having the Lipschitz shadowing property is Anosov.Comment: 11 page

Introduction: Turnaround and let-down: making sense of Brazil and Africa after the surge

By improving political connections under a common South-South aegis, promoting new trade opportunities and expanding the disbursement of significant amounts of development cooperation, Brazil quickly secured a foothold of its own in Africa between 2003 and 2014. However, in the face of a political meltdown and of controversial judicial investigations back home, Brazil’s inversions in Africa have since then essentially collapsed. This abrupt turnaround calls for a more critical exegesis of the years of expansion. What were the main successes and failures of Brazil’s overall strategy towards Africa? And what does the dramatic change of events, with Brazil moving from a pivotal player to an almost invisible one in merely half a decade, tell us about the possibility of a new pick-up of interest for Africa? This introduction to the edited volume takes stock of the main trends in previous literature over the character and content of Brazil’s foreign policy towards the continent and sets the ground for the following chapters.info:eu-repo/semantics/acceptedVersio

From opportunity seeking to gap filling: Reframing Brazil in Lusophone Africa

This chapter inquires whether Brazil’s headways in Africa over recent years were organic in nature and in content or, in fact, were achieved at the expense of other previously established actors. By reframing Brazil’s agenda towards African lusophone countries in juxtaposition to the perceived external downturn of Portugal, the propitious context and consequences of a new player on the continent can be best brought into evidence. The push-and-pull forces enacted by both Brazil and Portugal towards Lusophone Africa are explored through the aftermath of the 2012 military coup in Guinea-Bissau and the adhesion of Equatorial Guinea to the Community of Portuguese Language Countries (CPLP) in 2014. The chapter offers a reinterpretation of Brazil’s net gains in Africa and argues for its fragility and susceptibility to changing political-economic cycles.info:eu-repo/semantics/acceptedVersio

Consensus guidelines for the diagnosis and management of pyridoxine-dependent epilepsy due to α-aminoadipic semialdehyde dehydrogenase deficiency

Pyridoxine-dependent epilepsy (PDE-ALDH7A1) is an autosomal recessive condition due to a deficiency of α-aminoadipic semialdehyde dehydrogenase, which is a key enzyme in lysine oxidation. PDE-ALDH7A1 is a developmental and epileptic encephalopathy that was historically and empirically treated with pharmacologic doses of pyridoxine. Despite adequate seizure control, most patients with PDE-ALDH7A1 were reported to have developmental delay and intellectual disability. To improve outcome, a lysine-restricted diet and competitive inhibition of lysine transport through the use of pharmacologic doses of arginine have been recommended as an adjunct therapy. These lysine-reduction therapies have resulted in improved biochemical parameters and cognitive development in many but not all patients. The goal of these consensus guidelines is to re-evaluate and update the two previously published recommendations for diagnosis, treatment, and follow-up of patients with PDE-ALDH7A1. Members of the International PDE Consortium initiated evidence and consensus-based process to review previous recommendations, new research findings, and relevant clinical aspects of PDE-ALDH7A1. The guideline development group included pediatric neurologists, biochemical geneticists, clinical geneticists, laboratory scientists, and metabolic dieticians representing 29 institutions from 16 countries. Consensus guidelines for the diagnosis and management of patients with PDE-ALDH7A1 are provided. This article is protected by copyright. All rights reserved

Application of holistic liquid chromatography-high resolution mass spectrometry based urinary metabolomics for prostate cancer detection and biomarker discovery

Human exhibit wide variations in their metabolic profiles because of differences in genetic factors, diet and lifestyle. Therefore in order to detect metabolic differences between individuals robust analytical methods are required. A protocol was produced based on the use of Liquid Chromatography- High Resolution Mass Spectrometry (LC-HRMS) in combination with orthogonal Hydrophilic Interaction (HILIC) and Reversed Phase (RP) liquid chromatography methods for the analysis of the urinary metabolome, which was then evaluated as a diagnostic tool for prostate cancer (a common but highly heterogeneous condition). The LC-HRMS method was found to be robust and exhibited excellent repeatability for retention times (0.9. In addition, using the receiver operator characteristics (ROC) test, the area under curve (AUC) for the combination of the four best characterised biomarker compounds was 0.896. The four biomarker compounds were also found to differ significantly (

Population-level deficit of homozygosity unveils CPSF3 as an intellectual disability syndrome gene.

To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked DownloadPredicting the pathogenicity of biallelic missense variants can be challenging. Here, we use a deficit of observed homozygous carriers of missense variants, versus an expected number in a set of 153,054 chip-genotyped Icelanders, to identify potentially pathogenic genotypes. We follow three missense variants with a complete deficit of homozygosity and find that their pathogenic effect in homozygous state ranges from severe childhood disease to early embryonic lethality. One of these variants is in CPSF3, a gene not previously linked to disease. From a set of clinically sequenced Icelanders, and by sequencing archival samples targeted through the Icelandic genealogy, we find four homozygous carriers. Additionally, we find two homozygous carriers of Mexican descent of another missense variant in CPSF3. All six homozygous carriers of missense variants in CPSF3 show severe intellectual disability, seizures, microcephaly, and abnormal muscle tone. Here, we show how the absence of certain homozygous genotypes from a large population set can elucidate causes of previously unexplained recessive diseases and early miscarriage.Sacchi Foundatio