A UV-Spectrophotmetric Chemometric Method for the Simultaneous Determination of Sulfadoxine and Pyrimethamine in Tablets

In the present study, a simple, inexpensive, precise and accurate uv-spectrophotometric method based on chemometrics, has been developed for the simultaneous determination of sulfadoxine and pyrimethamine in tablet formulation. The % recoveries obtained were 99.7% ± 0.9 and 101.5% ± 0.8 for sulfadoxine and pyrimethamine, respectively. The developed method has been compared to USP-HPLC method with regard to accuracy and precision. The calculated F-ratio and the (t) statistics indicate that there is no significant difference at 5% level with regard to precision and accuracy between the proposed and the USP methods. Moreover, the developed method is simple, cost-effective, and less time-consuming. Accordingly, it can be used advantageously in routine quality control of sulfadoxine and pyrimethamine in tablet formulation

Affecting Factors Titanium Oxide of Nanoparticles for the Electrical Effect on Insulation Resistance of the Transformer Oil

In most cases, The electrical insulation of the transformer oil will be exposed to different internal problems, such as short circuit , over voltage, over load, over excitation and etcetera. The insulation of transformer will be sever decreased into minimum value. This requires some treatments of oil liquid ,such as refining or replacing the damaged oil with a new, which is a very expensive process. In this paper, the Insulation Resistance (IR) of transformer oil will be enhanced by using nanoparticles NPs. Titanium oxide (TiO2) one of them, which will be used in this experiment. The (NPs) improve the insulation, physical and chemical properties of transformer oil. The breakdown voltage will be tested for pure oil and after the addition (TiO2) according to IEC standard methods. The results of this study indicated that addition of TiO2 in certain quantities of pure oils can be affected the Insulation Resistance (IR) and electrical breakdown voltage. A comparative study was conducted to identify the effects of using nanoparticles in pure transformer oils to ensure their effect on electrical Insulation Resistance (IR). The results are indicated an increasing in the breakdown voltage and the dissipation factor of the transformer oil, thus results using nanoparticles oil higher than pure oil

Capacitive sensor based on molecularly imprinted polymers for detection of the insecticide imidacloprid in water

This manuscript reports on the development of a capacitive sensor for the detection of imidacloprid (IMD) in water samples based on molecularly imprinted polymers (MIPs). MIPs used as recognition elements were synthesized via a photo-initiated emulsion polymerization. The particles were carefully washed using a methanol (MeOH) / acetic acid mixture to ensure complete template removal and were then dried. The average size of the obtained particles was less than 1 mu m. The imprinting factor (IF) for IMD was 6 and the selectivity factor (alpha) for acetamiprid, clothianidin, thiacloprid and thiamethoxam were 14.8, 6.8, 7.1 and 8.2, respectively. The particles were immobilized on the surface of a gold electrode by electropolymerization. The immobilized electrode could be spontaneously regenerated using a mixture of MeOH/10 mM of phosphate buffer (pH = 7.2)/triethylamine before each measurement and could be reused for 32 times. This is the first-time that automated regeneration was introduced as part of a sensing platform for IMD detection. The developed sensor was validated by the analysis of artificially spiked water samples. Under the optimal conditions, the linearity was in the range of 5-100 mu M, with a limit of detection (LOD) of 4.61 mu M

Cosmological dynamics of fourth order gravity: A compact view

We construct a compact phase space for flat FLRW spacetimes with standard matter described by a perfect fluid with a barotropic equation of state for general f(R) theories of gravity, subject to certain conditions on the function f. We then use this framework to study the behaviour of the phase space of Universes with a non-negative Ricci scalar in R + {\alpha}R^n gravity. We find a number of interesting cosmological evolutions which include the possibility of an initial unstable power-law inflationary point, followed by a curvature fluid dominated phase mimicking standard radiation, then passing through a standard matter (CDM) era and ultimately evolving asymptotically towards a de-Sitter-like late-time accelerated phase.Comment: 8 pages, 3 figures, revtex4-

Flexible Bench-Scale Recirculating Flow CPC Photoreactor for Solar Photocatalytic Degradation of Methylene Blue Using Removable TiO 2

TiO2 immobilized on polyethylene (PET) nonwoven sheet was used in the solar photocatalytic degradation of methylene blue (MB). TiO2 Evonik Aeroxide P25 was used in this study. The amount of loaded TiO2 on PET was approximately 24%. Immobilization of TiO2 on PET was conducted by dip coating process followed by exposing to mild heat and pressure. TiO2/PET sheets were wrapped on removable Teflon rods inside home-made bench-scale recirculating flow Compound Parabolic Concentrator (CPC) photoreactor prototype (platform 0.7 × 0.2 × 0.4 m3). CPC photoreactor is made up of seven low iron borosilicate glass tubes connected in series. CPC reflectors are made of stainless steel 304. The prototype was mounted on a platform tilted at 30°N local latitude in Cairo. A centrifugal pump was used to circulate water containing methylene blue (MB) dye inside the glass tubes. Efficient photocatalytic degradation of MB using TiO2/PET was achieved upon the exposure to direct sunlight. Chemical oxygen demand (COD) analyses reveal the complete mineralization of MB. Durability of TiO2/PET composite was also tested under sunlight irradiation. Results indicate only 6% reduction in the amount of TiO2 after seven cycles. No significant change was observed for the physicochemical characteristics of TiO2/PET after the successive irradiation processes

Induced secondary metabolites from the endophytic fungus Aspergillus versicolor through bacterial co-culture and OSMAC approaches

LBK

Minimal Clinically Important Difference of the Standardized Cosmesis and Health Nasal Outcomes Survey

Background: The minimal clinically important difference (MCID) for the Standardized Cosmesis and Health Nasal Outcomes Survey (SCHNOS) has not been determined.Objectives: The authors sought to define the MCID for both domains of the SCHNOS questionnaire.Methods: This prospective cohort study included patients who underwent functional, cosmetic, or combined rhinoplasty operation from June 2017 to June 2018 at a tertiary referral center. The average preoperative, postoperative, and change in scores were calculated for the nasal obstruction symptom evaluation scale (NOSE) and SCHNOS. Anchor-based MCIDs were estimated for both SCHNOS subscales to define change in obstruction and cosmesis perceived after the rhinoplasty.Results: Eighty-seven patients (69% women, 31% males) with a mean age (standard deviation [SD]) of 38 years (14.7) at the time of surgery were included. The mean postoperative follow-up period (SD) was 145 days (117). The mean preoperative score (SD) for the NOSE was 52 (32), SCHNOS for nasal obstruction (SCHNOS-O) score was 55 (33), and SCHNOS for nasal cosmesis (SCHNOS-C) score was 50 (26) points. Postoperatively, the NOSE score was 23 (22), SCHNOS-O score was 24 (23), and SCHNOS-C score was 13 (18) points. The mean change in scores (SD) for NOSE, SCHNOS-O, and SCHNOS-C was -29 (37), -31 (38), and -37 (28), respectively. The calculated MCID for SCHNOS-O was 26 (16) and for SCHNOS-C was 22 (15) points. The MCID for NOSE was 24 (13) points. A sensitivity test for the patients with a follow-up >= 3 months showed only slightly different MCID estimates: 28 (17) for SCHNOS-O, 18 (13) for SCHNOS-C, and 24 (15) points for NOSE.Conclusions: For the obstruction domain SCHNOS-O, the MCID was 28 points. For the cosmetic domain SCHNOS-C, the MCID was 18 points.</div

Diosgenin alleviates D-galactose-induced oxidative stress in rats’ brain and liver targeting aging and apoptotic marker genes

The theory of aging is primarily concerned with oxidative stress caused by an imbalance in reactive oxygen species generation and cellular antioxidants. To alleviate the oxidative stress, we investigated the protective effect of diosgenin (DSG) for D-galactose (D-gal) using 20 and 40 mg of DSG/kg/day/orally for 42 days. The findings showed that D-gal caused brain and liver oxidative injuries by upregulating aging and oxidative markers. To counteract the oxidative stress caused by D-gal, DSG upregulated glutathione peroxidase-1, superoxide dismutase-1, and glutathione S-transferase-α. DSG also diminished the expression of p53, p21, Bcl-2-associated X protein, caspase-3, and mammalian target of rapamycin in brain and liver, as well as the build-up of β-galactosidase. DSG, in a dose-dependent manner, decreased the oxidative aging effects of D-gal in brain and liver tissues through targeting of aging and apoptotic marker genes. Finally, it should be noted that consuming DSG supplements is a suggesting natural preventative agent that may counteract aging and preserve health through improvement of body antioxidant status and control aging associated inflammation and cellular apoptosis