Using Genetic Programming to Predict Scour Downstream Rapid Hydraulic Structures from Experimental Results

Experimental Studie

Conductometric determination of sibutramine HCl, sumatriptan succinate and lomefloxacine HCl and the solubility products of their ion associates with molybdophosphoric acid

Conductometric determination of sibutramine HCl, sumatriptan succinate and lomefloxacine HCl with molybdophosphoric acid as a precipitating reagent was investigated. Various experimental conditions were evaluated and results obtained showed good recoveries, (mean recovery values of 100.51, 99.68, 99.41 and relative standard deviation of 0.332, 0.404, 0.509 for sibutramine HCl, sumatriptan succinate and lomefloxacine HCl, respectively). Numerical derivatization (first and second derivative) of the data was also applied, showing more accurate results compared to classical ones. The described procedures allowed the determination of equilibrium constants those indicated high degree of completeness of the precipitation reaction. Other parameters related to ion pair complex such as solubility and solubility product were also calculated. The described procedures allowed the determination of the studied drugs in the range of 5-15 mg. The precipitate obtained by ion pairing of lomefloxacine HCl with molybdophosphoric acid was spectroscopically characterized using IR. The method was further applied successively to pharmaceutical formulations, the proposed method offering a high degree of accuracy and precision when compared to reference methods

Phenolic Compounds from Sesame Cake and Antioxidant Activity: A New Insight for Agri-Food Residues’ Significance for Sustainable Development

Agri-food residues represent a rich source of nutrients and bioactive secondary metabolites, including phenolic compounds. The effective utilization of these by-products in food supplements and the nutraceuticals industry could provide a way of valorization in the transition to becoming more sustainable. In this context, the present study describes the phenolic profiling of sesame (Sesamum indicum L.) cake using reversed-phase high-performance liquid chromatography coupled to diode array detection and quadrupole-time-of-flight-mass spectrometry. Compounds were characterized based on their retention time, UV spectra, accurate mass spectrometry (MS) and MS/MS data along with comparison with standards, whenever possible, and the relevant literature. The characterized compounds (112 metabolites) belong to several classes, namely, phenolic acids (hydroxybenzoic acids and hydroxycinnamic acids), flavonoids, and lignans. Moreover, organic acids and some nitrogenous compounds were characterized. The total phenol content and the antioxidant activity of the cake extract were determined. This study provides useful information for the valorization of by-products from the sesame oil industry.This work was supported by the International Cooperation Cell ICC06 under the Erasmus Mundus—Al Idrisi II programme “scholarship scheme for exchange and cooperation between Europe and North Africa”. M.d.M.C. thanks the postdoctoral grant funded by the “Acción 6 del Plan de Apoyo a la Investigación de la Universidad de Jaén, 2017–2019”

Genetic affinities of Fusarim spp. and their correlation with origin and pathogenicity

Random amplified polymorphic DNA (RAPD) analyses was used in combination with pathogenicity assays to study the taxonomic kinships among five Fusarium species. A total of 46 isolates of Fusarium spp. obtained from diseased cotton seedlings showing typical root rot and dampping-off symptoms were characterized. Of 10 primers tested, four primers produced polymorphic amplification patterns with taxon-specific bands, in addition to individual-specific bands. Genetic analysis indicated into 2 main clusters, with the minor cluster included all F. moniliforme and F. solani at the genetic similarity of GS=57.82%. The major cluster consisted of all F. oxysporum, F. avenaceum and F. chlamydosporum clustered at 71% similarity. There was no clear-cut relationship between clustering in the RAPD dendrogram, pathogenicity test and geographic origin of tested isolates. The results suggest that RAPD-PCR is a useful method for analysing genetic variation within and between Fusarium spp. (African Journal of Biotechnology: 2003 2(5): 109-113

Novel Thiazole Derivatives of Medicinal Potential: Synthesis and Modeling

This paper reports on the synthesis of new thiazole derivatives that could be profitably exploited in medical treatment of tumors. Molecular electronic structures have been modeled within density function theory (DFT) framework. Reactivity indices obtained from the frontier orbital energies as well as electrostatic potential energy maps are discussed and correlated with the molecular structure. X-ray crystallographic data of one of the new compounds is measured and used to support and verify the theoretical results

Regulation of Vibrio mimicus metalloprotease (VMP) production by the quorum-sensing master regulatory protein, LuxR

Vibrio mimicus is an estuarine bacterium, while it can cause severe diarrhea, wound infection, and otitis media in humans. This pathogen secretes a relatively important toxin named V. mimicus metalloprotease (VMP). In this study, we clarified regulation of the VMP production according to the quorum-sensing master regulatory protein named LuxR. First, the full length of luxR gene, encoding LuxR, was detected in V. mimicus strain E-37, an environmental isolate. Next, the putative consensus binding sequence of LuxR protein could be detected in the upstream (promoter) region of VMP encoding gene, vmp. Finally, the effect of disruption of luxR gene on the expression of vmp and production of VMP was evaluated. Namely, the expression of vmp was significantly diminished by luxR disruption and the production of VMP was severely altered. Taken together, here we report that VMP production is under the positive regulation of the quorum-sensing master regulatory protein, LuxR

Antioxidant and cardioprotective activity of Stachys schimperi Vatke against doxorubicin-induced cardiotoxicity

AbstractCardiotoxicity is one of the major side effects of anthracycline antibiotics. Most studies implicated increased oxidative stress as the major determinant of doxorubicin (DOX) cardiotoxicity. The aim of the current investigation was to study the possible cardioprotective effect of Stachys schimperi Vatke (family Lamiaceae) on DOX-induced cardiotoxicity in rats based on biochemical and histopathological parameters. The phenolic profile of the methanol extract was determined qualitatively by HPLC. Isoscutellarein 7-O-[2″-O-(6″′-acetyl)-β-d-allopyranosyl]-β-d-glucopyranoside (compound 1) was isolated and identified from EB fraction as a major constituent for the first time from this Stachys species. The methanolic extract and the combined EtOAc and n-butanol fractions (EB) as well as compound 1 showed prominent free radical scavenging activity when assessed by the DPPH method. The methanolic extract showed moderate protection against DOX-induced alteration in cardiac oxidative stress markers; GSH and MDA, and cardiac serum markers; CK-MB and LDH activities. Additionally, histopathological study denoted mild protection against DOX-induced cardiotoxicity.It was concluded that Stachys schimperi Vatke methanolic extract protected against DOX-induced cardiotoxicity, at least in part, by virtue of its antioxidant activity

Статические цилиндрически-симметричные конфигурации идеальной жидкости

We study the properties of static, cylindrically symmetric configurations of a perfect fluid in general relativity, with the equation of state p = ωε with arbitrary values ω = const. We thus include into consideration the types of fluids which are now actively studied in cosmology (dark matter, cosmic strings, domain walls, quintessence, cosmic vacuum, phantom matter). Exact solutions to the Einstein equations with such fluids have been obtained for arbitrary values of ω. For any ω, we prove the absence of a flat spatial asymptotic as well as an asymptotic like that of a cosmic string. We show that all such distributions, under some conditions on the integration constants, have a regular axis and a spatial infinity at which the energy density tends to zero (except for configurations with ω = −1/3, which corresponds to a gas of cosmic strings). Thus such a system has a finite energy per unit length along the symmetry axis. In particular, for stiff matter (ω = 1), this quantity is equal to the Planck value of energy per unit length.Исследованы свойства статических цилиндрически-симметричных конфигураций идеальной жидкости в ОТО с уравнением состояния p = ωε при произвольном значении ω = const. Наряду с обычной материей рассмотрены типы идеальной жидкости, которые в настоящее время активно изучаются в космологии (тёмная материя, космические струны, доменные стенки, квинтэссенция, космический вакуум, фантомная материя). Получены точные решения уравнений Эйнштейна и идеальной жидкости при произвольном значении ω. Для произвольного ω доказано отсутствие плоской пространственной асимптотики, а также асимптотики типа космической струны. Показано, что все подобные распределения при некотором условии на константы интегрирования имеют регулярную ось и пространственную бесконечность, на которой плотность энергии стремится к нулю (за исключением конфигураций с ω = −1/3 - газа космических струн); при этом система обладает конечной энергией на единицу длины вдоль оси симметрии. В частности, в случае жёсткой материи (ω = 1) эта величина равна планковскому значению энергии на единицу длины

Synergistic Effects of Applying Potassium Nitrate Spray with Putrescine on Productivity and Fruit Quality of Mango Trees cv. Ewais

The current investigation represents of the synergistic effects of application of potassium nitrate (KNO3) in combination with putrescine (Put) on flowering, productivity, and fruit quality on Ewais mango (Mangifera indica L.) trees during the seasons 2021/2022 and 2022/2023. The selected trees were sprayed at three different stages, including flower bud differentiation, full bloom, and beginning of the fruit set, with one of the following treatments: control, 2% KNO3, 4% KNO3, 50 ppm Put, 75 ppm Put, 2% KNO3 + 50 ppm Put, 2% KNO3 + 75 ppm Put, 4% KNO3 + 50 ppm Put, 4% KNO3 + 75 ppm Put. Results showed that all treatments were successful in improving the productivity of mango trees by increasing flowering terminal shoots, fruit set, fruit retention, number of fruits/tree, yield, and fruit yield increment while reducing the percentage of fruit drop, as well as improving the quality of mango fruits cv. Ewais by increasing fruit length, fruit diameter, TSS, total sugars, V.C, and total phenol and carotenoid content, but at the same time, diminishing the total acidity, as compared with control. Based on this research, the application of 4% KNO3 in conjunction with 75 ppm Putrescine has shown the most prominent advances in enhancing Ewais tree productivity and fruit quality. The investigation successfully highlighted the synergistic effect of using KNO3 and putrescine to improve mango fruit yield and quality

Push Notification Service for Enhancing Relation between Parents and Educational Institutions: A case Study on Egyptian Schools.

With the growing interest in utilizing mobilecommunications to enhance the interactions between differentpartners in educational institutions, particularly in schools.However, how communicating with parents via applicationswhile aren't actively running is quite a challenging demand. Onthe other hand, the addressed success of the Android supportingfeatures provided a good candidate to support applications withreal time information. Moreover the Android platformssupports efficiently customizable notifications, which allowapplications based on Google Cloud Messaging (GCM) tospecify the pushed events. In this paper we demonstrate andvalidate the adequacy of mobile services to enhance theinteraction between schools and parents based on efficient useof push notification service in both real time and criticalinformation. The paper presents a proposed notification system;MParent, that actively provide alerts and messaging betweenparents and schools. Also, an open approach was used todetermine the reaction of the parents depending on what theywant to be pushed to their phones .The proposed system, theMParent, was implemented, tested and validated. Evaluationand questionnaire results have proven how proposed systemsatisfy both parties; parents and school administrations