Anti-Alzheimer and Anti-cox2 Activities of the Newly Synthesized 2,3’-Bipyridine Derivatives (I)

3-Aryl-1-pyridin-3-ylprop-2-en-1-ones 1a,b reacted with2-cyanoethanethioamide (2) to afford the corresponding4-aryl-6-thioxo-1,6-dihydro-2,3’-bipyridine-5-carbonitriles6a,b. The synthetic potentiality of compounds 6a,b wasinvestigated in the present study via their reactions withseveral active-hydrogen containing compounds 8a-g aimingto synthesize 4-aryl-6-pyridin-3-ylthieno[2,3-b]pyridin-3-amines 10a-n via 6-(alkylthio)-4-aryl-2,3’-bipyridine-5-carbonitriles 9a-n. The structures of all newly synthesizedheterocyclic compounds were elucidated by considering the data of IR, 1H NMR, mass spectra as well as that of elementalanalyses. Anti-Alzheimer and anti-cox2 activities for all newly synthesized heterocyclic compounds were investigated

Serological and Molecular Identification of Brucella spp. in Pigs from Cairo and Giza Governorates, Egypt

Brucellosis is considered as endemic disease of animals and humans since thousands of years in Egypt. However, brucellosis in pigs has never been reported in Egypt. Thus, serological and molecular assays were applied to detect anti-Brucella antibodies and DNA in serum samples collected from pigs. In total 331 blood samples collected from male and female pigs at slaughterhouses of Cairo and Giza governorates were investigated using Brucella c- and i-ELISA and Brucella real-time PCR. Anti-Brucella antibodies were detected in 16 (4.83%) and 36 (10.8%) sera by i-ELISA and c-ELISA, respectively. Brucella DNA was detected in 10 (3.02%) seropositive samples and identified as Brucella melitensis (7/10) and Brucella suis (3/10). A higher prevelance was found in boars. This is the first study investigating pig brucellosis in Egypt. The results of this study will raise awareness for brucellosis in these farm animals and will help to develop effective control strategies

Isolation of avian influenza H5N1 virus from vaccinated commercial layer flock in Egypt

Uninterrupted transmission of highly pathogenic avian influenza virus (HPAIV) H5N1 of clade 2.2.1 in Egypt since 2006 resulted in establishment of two main genetic clusters. The 2.2.1/C group where all recent human and majority of backyard origin viruses clustered together, meanwhile the majority of viruses derived from vaccinated poultry in commercial farms grouped in 2.2.1.1 clade. In the present investigation, an HPAIV H5N1 was isolated from twenty weeks old layers chickens that were vaccinated with a homologous H5N1 vaccine at 1, 7 and 16 weeks old. At twenty weeks of age, birds showed cyanosis of comb and wattle, decrease in egg production and up to 27% mortality. Examined serum samples showed low antibody titer in HI test (Log2 3.2 ± 4.2). The hemagglutinin (HA) and neuraminidase (NA) genes of the isolated virus were closely related to viruses in 2.2.1/C group isolated from poultry in live bird market (LBM) and backyards or from infected people. Conspicuous mutations in the HA and NA genes including a deletion within the receptor binding domain in the HA globular head region were observed. Despite repeated vaccination of layer chickens using a homologous H5N1 vaccine, infection with HPAIV H5N1 resulted in significant morbidity and mortality. In endemic countries like Egypt, rigorous control measures including enforcement of biosecurity, culling of infected birds and constant update of vaccine virus strains are highly required to prevent circulation of HPAIV H5N1 between backyard birds, commercial poultry, LBM and humans

Toxico-histological Effects of Sublethal Concentrations of Lead Nitrate on the Gills of the African Catfish, Clarias gariepinus

170-175This study aimed to investigate the effects of subleathal lead doses on the histological architecture of gills in the freshwater African catfish, Clarias gariepinus. Results revealed three stages of changes after exposure to three doses of lead nitrate. The changes were mild in fish exposed to 16.12 mg/L of Pb (NO3)2 (stage I 20% of LC50) and severe in case of 40% of LC50 (stage II, 32.24 mg/L) and 60% of LC50 (stage III 48.37% mg/L) in comparison to control. The histological examination revealed normal architecture of gills in control fish. Normal gills were characterized with primary gill lamellae with a central hyaline cartilage. However, three-stage changes were observed after exposure to the three doses of lead nitrate. In stage I, a cartilaginous matrix appeared along with loosening of the epithelial lining of the cartilaginous core and abundant vascular spaces were observed on the secondary gill lamellae. An extra cartilaginous matrix, loosening of the epithelial lining of the cartilaginous core, de-shaped gill lamellae, and degeneration of the secondary gill lamellae were noted in stage II. Lesions in the gill pattern in stage III were represented by shortening of the tips of secondary gill lamellae, damaged gill lamellae, a cartilaginous matrix, and hyperplasia. This indicated that lead exposure resulted in severe histopathological changes in the gills in a dose-dependent manner

Factor V G1691A (Leiden) is a major etiological factor in Egyptian Budd-Chiari syndrome patients

Objective: Budd-Chiari syndrome is a multifactorial disease in which several prothrombotic disorders may predispose patients to the development of thrombosis at this uncommon location (hepatic veins). The aim of this study was to determine the prevalence and characteristics of inherited thrombophilia in Egyptian Budd-Chiari syndrome patients.Materials and Methods: The study included 47 Budd-Chiari syndrome patients (20 children and 27 adults). Genotyping of Factor V G1691A (Leiden), prothrombin G20210A (PT), and methylenetetrahydrofolate reductase C677T were performed using real-time PCR and fluorescence melting curve detection analysis.Results: Factor V Leiden was observed in 29 patients (61.7%). It is the only factor that caused Budd-Chiari syndrome in 18 of the patients and in 5 of the patients with inferior vena cava involvement. Myeloproliferative disease was noted in 12 (25.5%) patients, antiphospholipid syndrome in 5 (10.6%), and Behcet’s disease in 3 (6.4%). Interestingly, 3 of the children with Budd-Chiari syndrome had lipid storage disease.Conclusion: Factor V Leiden was a major etiological factor in Egyptian Budd-Chiari syndrome patients, which may have been related to the high frequency of this mutation in the study region. Factor V Leiden was also a strong thrombophilic factor and the leading cause of inferior vena cava thrombosis in these patients. Lipid storage disease should be included as a risk factor for Budd-Chiari syndrome

Academic Satisfaction and Its Relationship to Internal Locus of Control among Students of Najran University

University students' satisfaction with their institution has individual, institutional and social implications. Several theories have been proposed in an effort to better understand the psychosocial dynamics of student satisfaction. The main objectives of this study are to examine the correlation between Internal Locus of Control and students' Academic Satisfaction with faculty staff, the college administration, and textbooks; and to evaluate differences between males and females on academic satisfaction scale. The study sample consists of (120) University students in Najran, KSA, from different majors and colleges, (69) males and (51) females. Academic Satisfaction Scale (ASS) and Internal Locus of Control Scale (ICS) have been developed by the author. There are significant positive correlations between satisfaction with faculty staff, satisfaction with the college administration and internal locus of control. The results found no significant correlation between satisfaction with textbooks and internal locus of control. The results also indicated significant differences between males and females on Academic Satisfaction Scale. This study summarizes the locus of control role on academic satisfaction assessment among university students.Keywords: orkforce sizing, job-shop production, holonic model Keywords: Academic satisfaction; locus of control; university students

Signaling mechanisms of a water soluble curcumin derivative in experimental type 1 diabetes with cardiomyopathy

BACKGROUND: Curcumin exhibits anti-diabetic activities, induces heme-oxygenase-1 (HO-1) and is an inhibitor of transcriptional co-activator p300. A novel water soluble curcumin derivative (NCD) has been developed to overcome low invivo bioavailability of curcumin. We evaluated the effect of the NCD on signaling mechanisms involved in cardiomyocyte hypertrophy and studied whether its action is mediated via inducible HO-1. MATERIALS AND METHODS: Rats were divided into controls, controls receiving NCD, diabetic, diabetic receiving NCD, diabetic receiving pure curcumin, diabetic receiving HO inhibitor, zinc protoporphyrin IX (ZnPP IX) and diabetic receiving NCD and ZnPP IX. NCD and curcumin were given orally. After 45 days, cardiac physiologic parameters, plasma glucose, insulin, glycated hemoglobin (GHb), HO-1 gene expression and HO activity in pancreas and cardiac tissues were assessed. Gene expression of p300, atrial natriuretic peptide (ANP) and myocyte enhancer factor 2 (MEF2A and MEF2C) were studied. RESULTS: NCD and curcumin decreased plasma glucose, GHb and increased insulin levels significantly in diabetic rats. This action may be partially mediated by induction of HO-1 gene. HO-1 gene expression and HO activity were significantly increased in diabetic heart and pancreas. Diabetes upregulated the expression of ANP, MEF2A, MEF2C and p300. NCD and curcumin prevented diabetes-induced upregulation of these parameters and improved left ventricular function. The effect of the NCD was better than the same dose of curcumin

Multibody approach for railway dynamic analysis

In the work presented, a computational tool used for the dynamic simulation of railway vehicle systems was developed using multibody systems formulations. The model based on the multibody techniques developed by Shabana. With respect to other exciting methodologies the proposed one make use of a combined frame of references that permit the use of independent coordinates, with out the possibility to have singularity configurations depending on the rotation sequence. The combined frame of references used as a base for the formulation and modeling of wheel-rail contact problem with high precision. The program was designed for considering with a flexible form the different configuration of railway vehicles. The main structure of the program has the ability of making changes for enhancement of the wheel-rail contact model or the implementation of dynamic structure of the track, which considered to be future aspects for a PHD dissertation. The model used was applied to make a simulation for single bogie , also for a complete vehicle with two bogies. The obtained results of the dynamic response for a defined track composed of, tangent segment, transition curve which take the form of a clothoid curve, and finally circular curve with constant radius. The calculations were made for different velocities, lower than the critical in which the vehicle responded in stable form, and higher than the critical at which the instability of the vehicle was studied.Elsayed Abdel Hameed Amer Shaltout, R. (2010). Multibody approach for railway dynamic analysis. http://hdl.handle.net/10251/13763Archivo delegad