Knowledge, Attitude and Practice in Electronic Education Among Teaching Staff and Students in Governmental Medical Faculties - Khartoum State

Background: Electronic education (E-education) is used worldwide as a basic tool for medical education for its advanced improving in medical training. In spite of its wide use in the system of the medical faculties in Sudan, e-education has not taken its right place yet.Objectives: To explore knowledge, attitude and practice (K.A.P) in  electronic education among teaching staff and students in governmental medical faculties in Khartoum state 2013.Materials and Methods: This is a descriptive, cross-sectional, and institution-based study. A sample of 31 teachers and 345 students were chosen using stratified random sample. Structured pretested questionnaire was used for data collection. Data collected were fed to Statistical Packagefor Social Sciences (SPSS) version 20.Results: Knowledge about e-education was excellent (91.3%), attitude was highly positive (83.9%) and practice was good among73.1%of the teachers. And among students knowledge about elearning was excellent (96.8%), attitude was positive in 70.4% and practice was average among52.2% of them.Conclusion: The research shows a good K.A.P among the majority of the students and teachers in Governmental Khartoum State medical faculties especially among teachers. The K.A.P. increases with age among teachers and increases in the clinical level among students. The faculties which take care of e-education and made workshops show higher K.A.P. compared with other faculties. The faculties should take attention to e-education and introduce it in the most ideal way, and more researches should be  conducted in this field.Key words: E-education, teaching staff and students, Khartoum state Governmental medical faculties

Essential oils from Egyptian aromatic plants as antioxidant and novel anticancer agents in human cancer cell lines

Inhibitors of tumor growth using extracts from aromatic plants are rapidly emerging as important new drug candidates for cancer therapy. The cytotoxicity and <em>in vitro</em> anticancer evaluation of the essential oils from thyme, juniper and clove has been assessed against five different human cancer cell lines (liver HepG2, breast MCF-7, prostate PC3, colon HCT116 and lung A549). A GC/MS analysis revealed that α-pinene, thymol and eugenol are the major components of Egyptian juniper, thyme and clove oils with concentrations of 31.19%, 79.15% and 82.71%, respectively. Strong antioxidant profiles of all the oils are revealed <em>in vitro</em> by DPPH and β-carotene bleaching assays. The results showed that clove oil was similarly potent to the reference drug, doxorubicin in prostate, colon and lung cell lines. Thyme oil was more effective than the doxorubicin in breast and lung cell lines while juniper oil was more effective than the doxorubicin in all the tested cancer cell lines except prostate cancer. In conclusion, the essential oils from Egyptian aromatic plants can be used as good candidates for novel therapeutic strategies for cancer as they possess significant anticancer activity.<br><br>Los inhibidores de crecimiento de tumores usando extractos de plantas aromáticas están emergiendo con rapidez como nuevos e importantes medicamentos para el tratamiento del cáncer. La citotoxicidad y la acción anticancerígena <em>in vitro</em> de aceites esenciales de tomillo, enebro y clavo han sido evaluadas en cinco líneas celulares de cáncer humano (hígado HepG2, mama MCF-7, próstata PC3, colon HCT116 y pulmón A549). Los análisis de GC/MS mostraron que α-pineno, timol y eugenol son los principales componentes de los aceites egipcios de enebro, tomillo y clavo, con concentraciones de 31,19%, 79,15% y 82,71%, respectivamente. Se demuestra, mediante ensayos <em>in vitro</em> de blanqueo de DPPH y β-caroteno, el enérgico perfil antioxidante de todos los aceites. Los resultados mostraron que el aceite de clavo fue similar de potente al fármaco de referencia, doxorrubicina en las líneas celulares de próstata, colon y pulmón. El aceite de tomillo fue más efectivo que la doxorrubicina en las líneas celulares de mama y de pulmón, mientras que el aceite de enebro fue más eficaz que la doxorrubicina en todas las líneas celulares de cáncer ensayados, excepto en la de cáncer de próstata. En conclusión, los aceites esenciales de plantas aromáticas egipcias se pueden utilizar como buenos candidatos para nuevas estrategias terapéuticas para el cáncer al poseer una significativa actividad anticancerígena

Factor XIII Gene Polymorphisms among Sudanese Patients with Intracerebral Hemorrhage, Khartoum State 2022

Background: Intracerebral hemorrhage (ICH) is a sudden bleeding into the tissues of the brain, into its ventricles, or into both. It is the second most common subtype of stroke and is a critical disease usually leading to severe disability or death. Material and method: This study was a cross sectional hospital-based study, conducted at the research laboratory of the national center of neurological sciences (NCNS), Khartoum, Sudan during the period June 2022 to August 2022.It included all patients attended with intracerebral hemorrhage. DNA extraction was done from blood of all patients and control. PCR for factor XIII gene was carried out and thus Sanger sequencing to both cases and controls. Results: The PCR results showed; 100% samples were positive for factor XIII gene.Sequencing result showed the detection of threepolymorphisms in factor XIII gene (G&gt;T, A&gt;G and C&gt;T) . Conclusion: The detected factor XIII gene polymorphisms (G&gt;T, A&gt;G and C&gt;T) might be associated with intercereberal hemorrhage among Sudanese patients. Keywords: Factor XIII, gene, polymorphism, hemorrhage, stroke, cerebrovascula