Arqueología al oeste de Homs: sondeos en los yacimientos de Jeftelik (Natufiense), Tell Marj (Neolítico cerámico) y prospecciones de monumentos megalíticos: campaña 2009

RESUMEN: En el artículo se presentan los resultados de los trabajos de campo desarrollados en el marco del proyecto "Arqueología al oeste de Homs" en 2009. Se han excavado los yacimientos de Jeftelik y Tell Marj y se ha continuado la prospección de las necrópolis megalíticas en la región. Jeftelik es un yacimiento natufiense antiguo en el que se ha localizado una probable estructura de habitación a la que está asociado una gran cantidad de material lítico tallado. Sus características y cronología ponen en cuestión los modelos convencionales sobre el origen y expansión del natufiense. Tell Marj es un poblado construido al final del neolítico en el que las casas cuentan con muros de basalto bien escuadrados. En el lugar se han reconocido dos fases de ocupación por el momento, la más antigua de las cuales muestra varias reconstrucciones y superposiciones de casas. Entre el material arqueológico destaca la extraordinaria abundancia de puntas de proyectil y la presencia de restos que sugieren la implantación de formas económicas y sociales complejas, con intercambios a larga distancia y almacenamiento a gran escala. Las necrópolis megalíticas reconocidas destacan por la gran extensión de las áreas ocupadas, de decenas de km., y por la existencia de monumentos complejos que a veces asocian otro tipo de estructuras a las construcciones funerarias propiamente dichas.ABSTRACT: This paper presents the results of the fieldwork carried out within the Project "Archaeology to the West of Homs" in 2009. The sites at Jeftelik and Tell Marj have been excavated and the work surveying the megalithic necropolis in the área has continued. Jeftelik is an early Natufian site, with a probable habitation structure associated with a large amount of knapped lithic objects. Its characteristics and chronology question conventional models about the origin and expansion of the Natufian. Tell Marj is a late Neolithic settlement, with houses with well-built rectangular basalt walls. Two occupation phases have been identified to date, in which the older phase exhibits several stages of re-building and superimposition of houses. The archaeological material found includes large numbers of projectile points and remains suggesting the incorporation of complex economic and social forms, with long-distance exchange networks and large-scale storage. The megalithic necropolises that have been studied cover large areas, several tens of square kilometres. Complex monuments have been identified, sometimes, associated with other types of structures apart from the funerary constructions themselves.Este proyecto está financiado por el Ministerio de Educación y Ciencia (proyectos i+D+i HUM2007-66128-C02-01 y 02), el Instituto de Patrimonio Cultural de España del Ministerio de Cultura, el programa EXCAVA de la Generalitat de Catalunya, la Universidad Saint-Joseph de Beirut y la Universidad de Cantabria

A phase II randomized trial comparing radiotherapy with concurrent weekly cisplatin or weekly paclitaxel in patients with advanced cervical cancer

<p>Abstract</p> <p>Purpose/Objective</p> <p>This is a prospective comparison of weekly cisplatin to weekly paclitaxel as concurrent chemotherapy with standard radiotherapy for locally advanced cervical carcinoma.</p> <p>Materials/Methods</p> <p>Between May 2000 and May 2004, 31 women with FIGO stage IB2-IVA cervical cancer or with postsurgical pelvic recurrence were enrolled into this phase II study and randomized to receive on a weekly basis either 40 mg/m²Cisplatin (group I; 16 patients) or 50 mg/m²paclitaxel (group II; 15 patients) concurrently with radiotherapy. Median total dose to point A was 74 Gy (range: 66-92 Gy) for group I and 66 Gy (range: 40-98 Gy) for group II. Median follow-up time was 46 months.</p> <p>Results</p> <p>Patient and tumor characteristics were similar in both groups. The mean number of chemotherapy cycles was also comparable with 87% and 80% of patients receiving at least 4 doses in groups I and II, respectively. Seven patients (44%) of group I and 8 patients (53%) of group II developed tumor recurrence. The Median Survival time was not reached for Group I and 53 months for group II. The proportion of patients surviving at 2 and 5 years was 78% and 54% for group I and 73% and 43% for group II respectively.</p> <p>Conclusions</p> <p>This small prospective study shows that weekly paclitaxel does not provide any clinical advantage over weekly cisplatin for concurrent chemoradiation for advanced carcinoma of the cervix.</p

Impact of COVID-19 on cardiovascular testing in the United States versus the rest of the world

Objectives: This study sought to quantify and compare the decline in volumes of cardiovascular procedures between the United States and non-US institutions during the early phase of the coronavirus disease-2019 (COVID-19) pandemic. Background: The COVID-19 pandemic has disrupted the care of many non-COVID-19 illnesses. Reductions in diagnostic cardiovascular testing around the world have led to concerns over the implications of reduced testing for cardiovascular disease (CVD) morbidity and mortality. Methods: Data were submitted to the INCAPS-COVID (International Atomic Energy Agency Non-Invasive Cardiology Protocols Study of COVID-19), a multinational registry comprising 909 institutions in 108 countries (including 155 facilities in 40 U.S. states), assessing the impact of the COVID-19 pandemic on volumes of diagnostic cardiovascular procedures. Data were obtained for April 2020 and compared with volumes of baseline procedures from March 2019. We compared laboratory characteristics, practices, and procedure volumes between U.S. and non-U.S. facilities and between U.S. geographic regions and identified factors associated with volume reduction in the United States. Results: Reductions in the volumes of procedures in the United States were similar to those in non-U.S. facilities (68% vs. 63%, respectively; p = 0.237), although U.S. facilities reported greater reductions in invasive coronary angiography (69% vs. 53%, respectively; p < 0.001). Significantly more U.S. facilities reported increased use of telehealth and patient screening measures than non-U.S. facilities, such as temperature checks, symptom screenings, and COVID-19 testing. Reductions in volumes of procedures differed between U.S. regions, with larger declines observed in the Northeast (76%) and Midwest (74%) than in the South (62%) and West (44%). Prevalence of COVID-19, staff redeployments, outpatient centers, and urban centers were associated with greater reductions in volume in U.S. facilities in a multivariable analysis. Conclusions: We observed marked reductions in U.S. cardiovascular testing in the early phase of the pandemic and significant variability between U.S. regions. The association between reductions of volumes and COVID-19 prevalence in the United States highlighted the need for proactive efforts to maintain access to cardiovascular testing in areas most affected by outbreaks of COVID-19 infection

Riparian habitat assessment tool for Lebanese rivers (RiHAT): case study Ibrahim River

Volume: 7Start Page: 99End Page: 11

Quality of Life, Knowledge and Access to Treatment in Times of Economic Crisis Among Lebanese Multiple Sclerosis Patients

International audienc

Arqueología al oeste de Homs: sondeos en los yacimientos de Jeftelik (natufiense), Tell Marj (neolítico cerámico) y prospecciones de monumentos megalíticos. Campaña 2009

[EN] This paper presents the results of the fieldwork carried out within the Project “Archaeology to the West of Homs” in 2009. The sites at Jeftelik and Tell Marj have been excavated and the work surveying the megalithic necropolis in the area has continued. Jeftelik is an early Natufian site, with a probable habitation structure associated with a large amount of knapped lithic objects. Its characteristics and chronology question conventional models about the origin and expansion of the Natufian. Tell Marj is a late Neolithic settlement, with houses with well-built rectangular basalt walls. Two occupation phases have been identified to date, in which the older phase exhibits several stages of re-building and superimposition of houses. The archaeological material found includes large numbers of projectile points and remains suggesting the incorporation of complex economic and social forms, with long-distance exchange networks and large-scale storage. The megalithic necropolises that have been studied cover large areas, several tens of square kilometres. Complex monuments have been identified, sometimes, associated with other types of structures apart from the funerary constructions themselves.[ES] En el artículo se presentan los resultados de los trabajos de campo desarrollados en el marco del proyecto “Arqueología al oeste de Homs” en 2009. Se han excavado los yacimientos de Jeftelik y Tell Marj y se ha continuado la prospección de las necrópolis megalíticas en la región. Jeftelik es un yacimiento natufiense antiguo en el que se ha localizado una probable estructura de habitación a la que está asociado una gran cantidad de material lítico tallado. Sus características y cronología ponen en cuestión los modelos convencionales sobre el origen y expansión del natufiense. Tell Marj es un poblado construido al final del neolítico en el que las casas cuentan con muros de basalto bien escuadrados. En el lugar se han reconocido dos fases de ocupación por el momento, la más antigua de las cuales muestra varias reconstrucciones y superposiciones de casas. Entre el material arqueológico destaca la extraordinaria abundancia de puntas de proyectil y la presencia de restos que sugieren la implantación de formas económicas y sociales complejas, con intercambios a larga distancia y almacenamiento a gran escala. Las necrópolis megalíticas reconocidas destacan por la gran extensión de las áreas ocupadas, de decenas de km., y por la existencia de monumentos complejos que a veces asocian otro tipo de estructuras a las construcciones funerarias propiamente dichas.Este proyecto está financiado por el Ministerio de Educación y Ciencia (proyectos i+D+i HUM2007-66128-C02-01 y 02), el Instituto de Patrimonio Cultural de España del Mnisterio de Cultura, el programa EXCAVA de la Generalitat de Catralunya, la Universidad Saint-Joseph de Beirut y la Universidad de Cantabria. Agradecemos a la su apoyo a la Dirección General de Antigüedades y Museos de la República Árabe de Siria.Peer Reviewe

Nadir PSA is a strong predictor of treatment outcome in intermediate and high risk localized prostate cancer patients treated by definitive external beam radiotherapy and androgen deprivation

Abstract Background The aim of this study is to investigate the effect of tumor characteristics and parameters of treatment response in predicting biochemical disease-free survival (BFS) for patients with intermediate or high risk prostate cancer treated by combined definitive external beam radiation therapy (EBRT) and androgen deprivation therapy (ADT). Methods Between June 1995 and January 2015, 375 patients with localized prostate cancer and a National Comprehensive Cancer Network (NCCN) intermediate or high risk categories were treated by definitive EBRT and ADT. Median duration of androgen blockade was 10 months (range: 3–36 months); Median radiation dose was 72 Gy (Range: 70–78 Gy). Median follow-up time was 5.8 years (range: 0.8–16.39 years). The main study endpoint was biochemical disease free survival (BFS). Results Forty seven patients (12.5%) developed biochemical recurrence (BCR) during the observation period. Monovariate analysis identified baseline PSA (bPSA) (p = 0.024), T-stage (p = 0.001), Gleason’s score (GS) (p = 0.042), radiation dose (p = 0.045), PSA pre-radiation therapy (p = 0.048), and nadir PSA (nPSA), (p < 0.001) as significant variables affecting BCR. The receiver operating characteristic (ROC) curve identified a nPSA of 0.06 ng/ml as optimal cut-off value significantly predicting the patients’ risk of BCR (p < 0.001). Multivariate cox regression analysis revealed T-stage, GS, and nPSA as independent variable affecting BFS, while bPSA, age, and radiation dose were not. Conclusion Nadir PSA at 0.06 is a strong independent predictor of BFS in patients with intermediate or high risk prostate cancer treated by definitive EBRT and ADT