Uniform generation in trace monoids

We consider the problem of random uniform generation of traces (the elements of a free partially commutative monoid) in light of the uniform measure on the boundary at infinity of the associated monoid. We obtain a product decomposition of the uniform measure at infinity if the trace monoid has several irreducible components-a case where other notions such as Parry measures, are not defined. Random generation algorithms are then examined.Comment: Full version of the paper in MFCS 2015 with the same titl

Retrospective study of epidemiological, clinicopathological and biological profils of 62 colorectal cancers cases in Jijel provence (Algeria)

In Algeria, the CRC wing and become the first digestive cancer in both sexes,  outperforming stomach cancer. To enrich the Algerian cancer registries, we analyzed the profiles of patients with these cancers in Jijel Willaya. This was a retrospective and descriptive analysis of epidemiological, clinicopathological and biological profiles of 62 CRC cases. We found that the CRC represented the first type of digestive cancers in which the three quarters were colon cancers. The most affected age group was 60-70 years with a male predominance and an average age of 56.20 years. The bleeding and abdominal pain were the majority telltale signs. The combined chemotherapy has been standardized with all patients and the Lieberkühnien adenocarcinoma was the major histological form. The disease issue and the choice of therapy depended on the K-RAS gene mutations. Our results were often compatible with the available literature and may provide reliable and relevant data on this disease.Key words: Colorectal cancer; Epidemiology; Therapy; Adenocarcinoma; K-RAS gen

Biological properties of carotenoids extracted from Halobacterium halobium isolated from a Tunisian solar saltern

Background: Bioactive molecules have received increasing attention due to their nutraceutical attributes and anticancer, antioxidant, antiproliferative and apoptosis-inducing properties. This study aimed to investigate the biological properties of carotenoids extracted from Archaea. Methods: Halophilic Archaea strains were isolated from the brine of a local crystallizer pond (TS7) of a solar saltern at Sfax, Tunisia. The most carotenoid-producing strain (M8) was investigated on heptoma cell line (HepG2), and its viability was assessed by the MTT-test. The cells were incubated with different sub-lethal extract rates, with carotenoid concentrations ranging from 0.2 to 1.5 μM. Antioxidant activity was evaluated through exposing the cells to sub-lethal extract concentrations for 24 hours and then to oxidative stress induced by 60 μM arachidonic acid and 50 μM H2O2. Results: Compared to non-treated cells, bacterial carotenoid extracts inhibited HepG2 cell viability (50%). A time and dose effect was observed, with cell viability undergoing a significant (P < 0.05) decrease with extract concentration. After exposure to oxidative stress, control cells underwent a significant (P < 0.05) decrease in viability as compared to the non-treated cells. Conclusions: The bacterial extracts under investigation were noted to exhibit the strongest free radical scavenging activity with high carotenoid concentrations. The carotenoid extract also showed significant antiproliferative activity against HepG2 human cancer cell lines

Big Line Bundles over Arithmetic Varieties

We prove a Hilbert-Samuel type result of arithmetic big line bundles in Arakelov geometry, which is an analogue of a classical theorem of Siu. An application of this result gives equidistribution of small points over algebraic dynamical systems, following the work of Szpiro-Ullmo-Zhang. We also generalize Chambert-Loir's non-archimedean equidistribution

Ramification theory for varieties over a local field

We define generalizations of classical invariants of wild ramification for coverings on a variety of arbitrary dimension over a local field. For an l-adic sheaf, we define its Swan class as a 0-cycle class supported on the wild ramification locus. We prove a formula of Riemann-Roch type for the Swan conductor of cohomology together with its relative version, assuming that the local field is of mixed characteristic. We also prove the integrality of the Swan class for curves over a local field as a generalization of the Hasse-Arf theorem. We derive a proof of a conjecture of Serre on the Artin character for a group action with an isolated fixed point on a regular local ring, assuming the dimension is 2.Comment: 159 pages, some corrections are mad

Assessment of digital image correlation measurement errors: methodology and results

Optical full-field measurement methods such as Digital Image Correlation (DIC) are increasingly used in the field of experimental mechanics, but they still suffer from a lack of information about their metrological performances. To assess the performance of DIC techniques and give some practical rules for users, a collaborative work has been carried out by the Workgroup “Metrology” of the French CNRS research network 2519 “MCIMS (Mesures de Champs et Identification en Mécanique des Solides / Full-field measurement and identification in solid mechanics, http://www.ifma.fr/lami/gdr2519)”. A methodology is proposed to assess the metrological performances of the image processing algorithms that constitute their main component, the knowledge of which being required for a global assessment of the whole measurement system. The study is based on displacement error assessment from synthetic speckle images. Series of synthetic reference and deformed images with random patterns have been generated, assuming a sinusoidal displacement field with various frequencies and amplitudes. Displacements are evaluated by several DIC packages based on various formulations and used in the French community. Evaluated displacements are compared with the exact imposed values and errors are statistically analyzed. Results show general trends rather independent of the implementations but strongly correlated with the assumptions of the underlying algorithms. Various error regimes are identified, for which the dependence of the uncertainty with the parameters of the algorithms, such as subset size, gray level interpolation or shape functions, is discussed

Use of FreeStyle Libre Flash Monitor Register in the Netherlands (FLARE-NL1):Patient Experiences, Satisfaction, and Cost Analysis

In patients with diabetes mellitus (DM), adequate glucose control is of major importance. When treatment schemes become more complicated, proper self-management through intermittent self-measurement of blood glucose (SMBG), among others, becomes crucial in achieving this goal. In the last decade, continuous glucose monitoring (CGM) has been on the rise, providing not only intermittent information but also information on continuous glucose trends. The FreeStyle Libre (FSL) Flash CGM system is a CGM system mainly used for patients with DM and is designed based on the same techniques as early CGMs. Compared with earlier CGMs, the FSL is factory calibrated, has no automated readings or direct alarms, and is cheaper to use. Although less accurate compared with the gold standard for SMBG, users report high satisfaction because it is easy to use and can help users monitor glucose trends. The Flash Monitor Register in the Netherlands (FLARE-NL) study aims to assess the effects of FSL Flash CGM use in daily practice. The study has a before-after design, with each participant being his or her own control. Users will be followed for at least 1 year. The endpoints include changes in HbA1c, frequency and severity of hypoglycemias, and quality of life. In addition, the effects of its use on work absenteeism rate, diabetes-related hospital admission rate, and daily functioning (including sports performance) will be studied. Furthermore, cost-benefit analysis based on the combination of registered information within the health insurance data will be investigated. Ultimately, the data gathered in this study will help increase the knowledge and skills of the use of the Flash CGM in daily practice and assess the financial impact on the use of the Flash CGM within the Dutch healthcare system

Prediction of airborne radiated noise from lightly loaded lubricated meshing gear teeth

This paper introduces a novel analytical method for determination of gear airborne noise under lightly loaded conditions, often promoting gear rattle of loose unengaged gear pairs. The system examined comprises a single gear pair, modelled through integrated contact tribology and inertial transient dynamics. Lubricant film thickness, structural vibration and airborne gear noise are predicted and correlated with experimental measurements undertaken in a semi-anechoic environment. Good agreement is noticed between the numerical predictions and the experimental measurements. The presented model is capable of estimating the airborne radiated gear noise levels and the dynamic behaviour of gear pairs under different operating conditions, with superimposed impulsive input speed harmonics

Performance of the FreeStyle Libre Flash glucose monitoring system in patients with type 1 and 2 diabetes mellitus

OBJECTIVE: To evaluate the performance of the FreeStyle Libre Flash continuous glucose monitoring (FSL-CGM) system against established central laboratory methods. RESEARCH DESIGN AND METHODS: 20 subjects (8 type 1 diabetes mellitus, 12 type 2 diabetes mellitus) were analyzed. FSL-CGM sensor measurements (inserted in arm and abdomen) were compared with capillary blood glucose results analyzed with StatStrip as semigold standard. The glucose response after a standardized oral glucose load was measured by FSL-CGM and capillary samples analyzed by perchloric acid hexokinase (PCA-HK) method, StatStrip and FSL test strip (FSLC), and a commonly used CGM system (iPro2). RESULTS: FSL-CGM arm sensor readings showed 85.5% of paired readings falling within Clarke Error Grid (ISO 15197:2013) zone A when compared with StatStrip. For FSL-CGM abdomen and FSLC, these percentages were 64% and 98%, respectively. The overall correlation of FSL-CGM in the arm and the StatStrip indicates a performance with lower results with the FSL-CGM in the arm than expected based on the StatStrip in the lower glucose ranges, and higher results than expected in the higher ranges. Following a standardized glucose load, a slower rise in glucose level was observed for FSL-CGM arm as compared with PCA-HK, StatStrip, FSLC, and iPro2 during the first 45–60 min after glucose load ingestion. CONCLUSIONS: Certain matters need attention while using the FSL-CGM in daily life including the observed lower values in the lower ranges, and the underestimation of the effect of a meal on glucose response. These effects of such deviations can partly be overcome by optimizing the available user instructions. TRIAL REGISTRATION NUMBER: TC5348; results

Majorations explicites de fonctions de Hilbert-Samuel géométrique et arithmétique

International audienceBy using the $\mathbb R$-filtration approach of Arakelov geometry, one establishes explicit upper bounds for geometric and arithmetic Hilbert-Samuel function for line bundles on projective varieties and hermitian line bundles on arithmetic projective varieties