109 research outputs found

    Advances in Development of Quartz Crystal Oscillators at Liquid Helium Temperatures

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    This work presents some recent results in the field of liquid helium {bulk acoustic wave} oscillators. The discussion covers the whole development procedure starting from component selection and characterization and concluding with actual phase noise measurements. The associated problems and limitations are discussed. The unique features of obtained phase noise power spectral densities are explained with a proposed extension of the Leeson effect.Comment: Cryogenics, 201

    Operation of graphene-on-quartz acoustic cavity at cryogenic temperatures

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    This paper presents observation of mechanical effects of a graphene monolayer deposited on a quartz substrate designed to operate as an extremely low-loss acoustic cavity standard at liquid-helium temperature. Resonances of this state-of-the-art cavity are used to probe the mechanical loss of the graphene film, assessed to be about 80 10−480 \: 10^{-4} at 4K. Significant frequency shifts of positive and negative sign have been observed for many overtones of three modes of vibration. These shifts cannot be predicted by the mass-loading model widely used in the Quartz Microbalance community. Although thermo-mechanical stresses are expected in such a graphene-on-quartz composite device at low temperature due to a mismatch of expansion coefficients of both materials, it cannot fully recover the mismatch of the mass loading effect. Based on a force-frequency theory applied to the three thickness modes, to reconcile the experimental results, the mean stresses in the graphene monolayer should be of the order of 140 GPa, likely close to its tensile strength.Comment: Corrected typos. New Fig. Text improve

    A new method of probing mechanical losses of coatings at cryogenic temperatures

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    A new method of probing mechanical losses and comparing the corresponding deposition processes of metallic and dielectric coatings in 1-100 MHz frequency range and cryogenic temperatures is presented. The method is based on the use of extremely high-quality quartz acoustic cavities whose internal losses are orders of magnitude lower than any available coatings nowadays. The approach is demonstrated for Chromium, Chromium/Gold and a multilayer tantala/silica coatings. The Ta2O5/SiO2{\rm Ta}_2{\rm O}_5/{\rm Si}{\rm O}_2 coating has been found to exhibit a loss angle lower than 1.6×10−51.6\times10^{-5} near 30 {\rm MHz} at 4 {\rm K}. The results are compared to the previous measurements

    Laser light routing in an elongated micromachined vapor cell with diffraction gratings for atomic clock applications

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    International audienceThis paper reports on an original architecture of microfabricated alkali vapor cell designed for miniature atomic clocks. The cell combines diffraction gratings with anisotropically etched single-crystalline silicon sidewalls to route a normally-incident beam in a cavity oriented along the substrate plane. Gratings have been specifically designed to diffract circularly polarized light in the first order, the latter having an angle of diffraction matching the (111) sidewalls orientation. Then, the length of the cavity where light interacts with alkali atoms can be extended. We demonstrate that a longer cell allows to reduce the beam diameter, while preserving the clock performances. As the cavity depth and the beam diameter are reduced, collimation can be performed in a tighter space. This solution relaxes the constraints on the device packaging and is suitable for wafer-level assembly. Several cells have been fabricated and characterized in a clock setup using coherent population trapping spectroscopy. The measured signals exhibit null power linewidths down to 2.23 kHz and high transmission contrasts up to 17%. A high contrast-to-linewidth ratio is found at a linewidth of 4.17 kHz and a contrast of 5.2% in a 7-mm-long cell despite a beam diameter reduced to 600 ÎŒm

    Impact of Reporting Bias in Network Meta-Analysis of Antidepressant Placebo-Controlled Trials

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    BACKGROUND: Indirect comparisons of competing treatments by network meta-analysis (NMA) are increasingly in use. Reporting bias has received little attention in this context. We aimed to assess the impact of such bias in NMAs. METHODS: We used data from 74 FDA-registered placebo-controlled trials of 12 antidepressants and their 51 matching publications. For each dataset, NMA was used to estimate the effect sizes for 66 possible pair-wise comparisons of these drugs, the probabilities of being the best drug and ranking the drugs. To assess the impact of reporting bias, we compared the NMA results for the 51 published trials and those for the 74 FDA-registered trials. To assess how reporting bias affecting only one drug may affect the ranking of all drugs, we performed 12 different NMAs for hypothetical analysis. For each of these NMAs, we used published data for one drug and FDA data for the 11 other drugs. FINDINGS: Pair-wise effect sizes for drugs derived from the NMA of published data and those from the NMA of FDA data differed in absolute value by at least 100% in 30 of 66 pair-wise comparisons (45%). Depending on the dataset used, the top 3 agents differed, in composition and order. When reporting bias hypothetically affected only one drug, the affected drug ranked first in 5 of the 12 NMAs but second (n = 2), fourth (n = 1) or eighth (n = 2) in the NMA of the complete FDA network. CONCLUSIONS: In this particular network, reporting bias biased NMA-based estimates of treatments efficacy and modified ranking. The reporting bias effect in NMAs may differ from that in classical meta-analyses in that reporting bias affecting only one drug may affect the ranking of all drugs

    Cryogenic transistor measurement and modeling for engineering applications

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    International audienceThis article deals with the methodology of an electronic system design at liquid-helium temperatures. This technique includes the active device selection, characterization and simulation. Based on certain engineering criteria one commercial reference of SiGe heterojunction bipolar transistors is selected. Then, the technique of device characterization and measurement is considered. Typical output characteristics are given for this reference. All the tested devices of this reference are classified into three groups according to the presence of different low-temperature phenomena. An accurate and easy-to-use neural network model based on their experimental DC characteristics is proposed. This model is implemented in Agilent ADS Software, and the simulation results are compared with measurements in the course of the cryogenic amplifier design
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