Proposed new interior design scheme of musical instrument retail at 26-8A,8B,8C,Jln Theatre,30300,Ipoh,Perak for Bentley Music Sdn. Bhd. / Aaron Ashley Awah

As the musical passion of the Malaysian are growing tremendously. Musical instrument retail is playing one of the important of providing quality and branded instrument to the people. To be able to be stick out in this field, Musical instrument retailers will have to think of a revolutionary idea to overcome the competitive market. This project is to proposed a new branch of Musical Instrument Retail for Bentley Music Sdn. Bhd. at other state instead of Kuala Lumpur, and I have chosen Ipoh, Perak, which located at. The objective of this proposal is to create a new vision of Musical Instrument Store which emphasize of fresh and youthful ideas where most of the Musical instrument store does n o t. On the other hand .solving the spatial arrangement of the shop is also one of my purpose and the anticipating turnout is customer will be satisfied with the retail services and experience a fresh type of musical instrument retail. The reason I doing this project is due to the lack of efficiency of space arrangement in the shop and the dullness of typical musical instrument store. Therefore, a new design is prepare which it may enlighten and satisfy the both the owner, workers and most importantly the customers. A concept that meets the corporate image is highly taken into designing process. And from all the researchdata and details that collected was use as a reference in this design

The validity and reliability of the Basketball Jump Shooting Accuracy Test

The aim of this study was to examine the content validity, construct validity and reliability of the newly developed Basketball Jump Shooting Accuracy Test (BJSAT). Basketball athletes from different playing levels (State Basketball League [SBL], n = 30, age: 22.7 ± 6.1 yr; SBL Division I, n = 11, age: 20.6 ± 2.1 yr) completed four separate trials of the BJSAT with each trial consisting of shot attempts from two- and three-point distances at pre-determined court locations. Each shot attempt was scored utilising a criteria where higher scores were given when greater accuracy was exhibited. The BJSAT detected a significant, large difference in accuracy between two- and three-point shots (d = 0.99, p \u3c 0.01). Relative reliability across the repeated trials was rated as moderate for all athletes (intraclass correlation coefficient [ICC] = 0.71, p \u3c 0.01) and goodfor the SBL athletes (ICC = 0.78, p \u3c 0.01). Absolute reliability for all athletes was above the acceptable benchmark (coefficient of variation = 16.2%); however superior to skill tests available in the literature. In conclusion, the BJSAT is sensitive to two- and three-point shooting accuracy and can reliably assess jump shooting accuracy in basketball athletes

Introducing the Interdisciplinary Nature of Health Care Through Case Study Models

Interprofessional education (IPE) is a critical area needed to improve the quality of healthcare. Stereotypes of other disciplines persist by healthcare workers, limiting the ability to work as a team. Knowledge of roles of healthcare professions is a key competency of IPE. An online, 12-week course was developed to introduce students to the interdisciplinary nature of healthcare through case study models. Through built-in links, students explore medical terminology, diagnostic testing, pathophysiology, treatment, and health professionals who work as a team to diagnose and treat the patient. A 24-question survey was administered to a convenience sample of 582 high school students. Results of paired-samples t-tests showed significant increases pre-training to post-training in: 1) knowledge of the different roles of health professionals, (n = 338, M = .71, SEM = .01) to post-training (M = .82, SEM = .01), t(337) = 11.08, p<.001, pη2 = .203, 2) and self-reported knowledge of roles of different health professions, pre-training (n = 338, M = 2.73, SEM = .30) to post-training (M = 3.60, SEM = .039), t(337) = 20.02, p < .001, pη2 = .543. Interestingly, students’ likelihood in a career in healthcare professions decreased significantly pre-training (n = 338, M = 4.30, SEM = .043) to post-training (M = 4.20, SEM = .06), t(337) = 2.21, p = .028, pη2 = .016. Introducing knowledge of health professions to this population may be critical in avoiding stereotypes before a student enters a chosen career path, increasing the likelihood of participation in interdisciplinary teams

Determining the Impact of Increased Physical Activity on Improving Sleep Quality in Young Adults

Determining the Impact of Increased Physical Activity on Improving Sleep Quality in Young Adults Disturbed sleep, defined as any alteration to normal sleep patterns, has been linked to poor cardiovascular health and an increase in cardiovascular disease (CVD) risk. These negative sleep patterns are highly prevalent with 35% to 41% of individuals in the United States reported some form of disturbed sleep. Although high amounts of physical activity (PA) are often associated with high sleep quality, little is known about PA’s effectiveness to improve different aspects of sleep (e.g. duration vs quality) and the mechanisms to which it can improve sleep quality. Purpose: The study sought to determine the ability of increased PA to improve sleep efficiency in healthy young adults. Methods: Nineteen young adults (25±4 yrs) were recruited for this study. Subjects wore an accelerometer (Actigraph GT3x-BT) for a total of three weeks to record daily physical activity (step count; low, moderate, and vigorous physical activity) and sleep variables (efficiency, wake after sleep onset, number of nightly awakenings, time per awakening, and total sleep time). Subjects maintained normal physical activity levels for the first week (BL), then increased their step count by an average of 5,000 steps/day across the next two weeks (W1 and W2). Heart rate variability (HRV) and venous blood draws were collected weekly to assess sympathetic activity and inflammation, respectively. Results: The physical activity intervention resulted in significant increases (p \u3c 0.001) in step-count for both W1 (13163 ± 3184) and W2 (12168 ± 3619) when compared to BL (8648 ± 2615 steps/day). No significant differences from BL were observed when examining sleep efficiency (BL: 83.8 ± 6.4; W1: 85.5 ± 4.0; W2: 84.2 ± 6.1 %), sympathetic-vagal balance, and inflammatory marker concentrations in W1 and W2. A significant correlation was revealed when assessing the change in sleep efficiency from BL to W1 (r = 0.81, p \u3c 0.001) and BL to W2 (r = 0.52, p = 0.02) when compared to initial sleep efficiency values. Conclusion: This study revealed that although young healthy individuals appear to lack improvements in sleep efficiency with an increase in physical activity, those who reported the lowest sleep quality had the greatest improvements in sleep efficiency following an increase in physical activity. Therefore, the findings of the study suggest that although increasing physical activity can improve sleep quality, a potential “ceiling effect” may occur, as when sleep quality is adequate, augmenting physical activity no longer has a substantial effect.https://scholarscompass.vcu.edu/gradposters/1058/thumbnail.jp

Engineered single nucleotide polymorphisms in the mosquito MEK docking site alter Plasmodium berghei development in Anopheles gambiae.

BackgroundSusceptibility to Plasmodium infection in Anopheles gambiae has been proposed to result from naturally occurring polymorphisms that alter the strength of endogenous innate defenses. Despite the fact that some of these mutations are known to introduce non-synonymous substitutions in coding sequences, these mutations have largely been used to rationalize knockdown of associated target proteins to query the effects on parasite development in the mosquito host. Here, we assay the effects of engineered mutations on an immune signaling protein target that is known to control parasite sporogonic development. By this proof-of-principle work, we have established that naturally occurring mutations can be queried for their effects on mosquito protein function and on parasite development and that this important signaling pathway can be genetically manipulated to enhance mosquito resistance.MethodsWe introduced SNPs into the A. gambiae MAPK kinase MEK to alter key residues in the N-terminal docking site (D-site), thus interfering with its ability to interact with the downstream kinase target ERK. ERK phosphorylation levels in vitro and in vivo were evaluated to confirm the effects of MEK D-site mutations. In addition, overexpression of various MEK D-site alleles was used to assess P. berghei infection in A. gambiae.ResultsThe MEK D-site contains conserved lysine residues predicted to mediate protein-protein interaction with ERK. As anticipated, each of the D-site mutations (K3M, K6M) suppressed ERK phosphorylation and this inhibition was significant when both mutations were present. Tissue-targeted overexpression of alleles encoding MEK D-site polymorphisms resulted in reduced ERK phosphorylation in the midgut of A. gambiae. Furthermore, as expected, inhibition of MEK-ERK signaling due to D-site mutations resulted in reduction in P. berghei development relative to infection in the presence of overexpressed catalytically active MEK.ConclusionMEK-ERK signaling in A. gambiae, as in model organisms and humans, depends on the integrity of conserved key residues within the MEK D-site. Disruption of signal transmission via engineered SNPs provides a purposeful proof-of-principle model for the study of naturally occurring mutations that may be associated with mosquito resistance to parasite infection as well as an alternative genetic basis for manipulation of this important immune signaling pathway

Integrating methods for determining length-at-age to improve growth estimates for two large scombrids

Fish growth is commonly estimated from length-at-age data obtained from otoliths. There are several techniques for estimating length-at-age from otoliths including 1) direct observed counts of annual increments; 2) age adjustment based on a categorization of otolith margins; 3) age adjustment based on known periods of spawning and annuli formation; 4) back-calculation to all annuli, and 5) back-calculation to the last annulus only. In this study we compared growth estimates (von Bertalanffy growth functions) obtained from the above five methods for estimating length-at-age from otoliths for two large scombrids: narrow-barred Spanish mackerel (Scomberomorus commerson) and broad-barred king mackerel (Scomberomorus semifasciatus). Likelihood ratio tests revealed that the largest differences in growth occurred between the back-calculation methods and the observed and adjusted methods for both species of mackerel. The pattern, however, was more pronounced for S. commerson than for S. semifasciatus, because of the pronounced effect of gear selectivity demonstrated for S. commerson. We propose a method of substituting length-at-age data from observed or adjusted methods with back-calculated length-at-age data to provide more appropriate estimates of population growth than those obtained with the individual methods alone, particularly when faster growing young fish are disproportionately selected for. Substitution of observed or adjusted length-at-age data with back-calculated length-at-age data provided more realistic estimates of length for younger ages than observed or adjusted methods as well as more realistic estimates of mean maximum length than those derived from backcalculation methods alone

Vascular Dysfunction and Posttraumatic Stress Disorder: Examining the Role of Oxidative Stress and Sympathetic Activity

Purpose: The physiological manifestations of posttraumatic stress disorder (PTSD) have been associated with an increase in risk of cardiovascular disease (CVD) independent of negative lifestyle factors. The goal of the study was to better elucidate the mechanisms behind the increased CVD risk by examining peripheral vascular function, a precursor to CVD. Moreover, this study sought to determine the role of oxidative stress and sympathetic nervous system (SNS) activity in PTSD-induced vascular dysfunction. Methods: Sixteen individuals with PTSD (10 women, 6 men; age 24 ± 4 years), and twenty-four healthy controls (CTRL; 15 women, 9 men, 24 ± 4 years), participated in the study. The PTSD group participated in two visits, consuming either a placebo or antioxidant cocktail (AO - vitamins C and E and alpha lipoic acid) prior to their visits, in a randomized order. Arm vascular function was assessed via the reactive hyperemia- induced flow mediated dilation of the brachial artery (BAFMD) technique and evaluated with Doppler ultrasonography. Brachial artery and arm microvascular function were determined by percent change of diameter from baseline normalized for BA shear rate (BAD/Shear), and blood flow area under the curve (BF AUC), respectively. Heart rate variability (HRV) was used to assess autonomic nervous system activity. Results: BF AUC was significantly lower (p = 0.02) and SNS activity was significantly higher (p = 0.02) in the PTSD group when compared to the CTRL group. BAD/Shear was not different between groups. Following the acute AO supplementation, BF AUC was augmented to which it was no longer significantly different (p = 0.16) when compared to the CTRL group. SNS activity within the PTSD group was significantly reduced (p=.007) following the AO supplementation when compared to the PL condition, and the difference between PTSD and CTRL was no longer significant (p=.41). Conclusion: Young individuals with PTSD demonstrated lower arm microvascular, but not brachial artery, function as well as higher sympathetic activity when compared to healthy controls matched for age, sex, and physical activity level. Furthermore, this microvascular dysfunction and SNS activity was attenuated by an acute AO supplementation to the level of the healthy controls. Taken together, this study revealed that the modulation of oxidative stress, via an acute AO supplementation, improved vascular dysfunction in individuals with PTSD, potentially by reducing the substantial SNS activity associated with this disorder.https://scholarscompass.vcu.edu/gradposters/1084/thumbnail.jp

Land-Based Learning: A Learning Paradigm for Building Community and Sustainable Farms

Mitigating complex problems is increasingly essential to sustaining life on Earth. Empowering current and future generations to address these problems requires rethinking traditional education approaches. This article serves as a primer for land-based learning—defined as a pedagogical approach in which learners collaborate with community members to implement place-based interventions within agricultural systems to increase the sustainability of their community. As an introduction to land-based learning, the article (a) describes critical checkpoints within land-based learning, (b) illuminates the role of Extension educators in facilitating land-based learning, and (c) introduces a case study of land-based learning in Michigan\u27s Upper Peninsula

Water Systematics of Samoan Peridotite Xenoliths

Water influences geodynamic processes such as melting, deformation and rheology. Yet its distribution in the oceanic upper mantle is primarily known indirectly from melt inclusions and glasses of erupted mantle melts (i.e. MORB and OIB). To constrain the mechanisms influencing the distribution of water in the mantle, we analyzed 15 peridotite xenoliths from Savaiʻi and 2 dunite xenoliths from Taʻū (Samoa) for water concentrations (by polarized FTIR) and major/trace elements. Savaiʻi peridotites are among the most melt depleted oceanic xenoliths recovered (degrees of melt depletion ≥15%). They show strong evidence of transient metasomatism by both carbonatite and silicate melts, with highly variable Ti and Zr depletions and LREE enrichments down to the grain scale, but which are up to an order of magnitude more depleted than expected for metasomatism. LA-ICP-MS analyses of inclusion-rich and - poor domains within single mineral grains reveal significant heterogeneity and patterns with strong carbonatite and silicate characteristics. Despite this, water concentrations of olivines (up to 4 ppm H2O) and orthopyroxene (17 to 89 ppm H2O) are among the lowest reported in oceanic xenoliths. Orthopyroxene H2O correlate with indicators of melt depletion (i.e. Al, Mg#) and not metasomatism (i.e. LREE, Ti). Yet, they are higher than expected for melt depletion, but also up to two orders of magnitude lower than expected for metasomatism by presumably water-rich melts. FTIR transects across mineral grains show generally flat water profiles, indicating no significant water loss during ascent, and show no significant difference between inclusion-rich and -poor domains. Also, Raman Spectroscopy on single inclusions shows the presence of CO2 but lack H2O. If the melt-inclusion trails had several weight % water, as estimated for carbonatites, diffusion of water from the inclusions into the host phase would lower their water contents and simultaneously enrich water across the grain. This mechanism, but on a larger scale, likely also affected the Taʻū dunites. Their clinopyroxenes show trace element systematics consistent with their host lavas, but with water contents several times lower than expected. Thus, melt-rock interactions in the oceanic lithosphere are complex processes that result in variable hydration of the lithosphere