On the Virialization of Disk Winds: Implications for the Black Hole Mass Estimates in AGN

Estimating the mass of a supermassive black hole (SMBH) in an active galactic nucleus (AGN) usually relies on the assumption that the broad line region (BLR) is virialized. However, this assumption seems invalid in BLR models that consists of an accretion disk and its wind. The disk is likely Keplerian and therefore virialized. However, the wind material must, beyond a certain point, be dominated by an outward force that is stronger than gravity. Here, we analyze hydrodynamic simulations of four different disk winds: an isothermal wind, a thermal wind from an X-ray heated disk, and two line-driven winds, one with and the other without X-ray heating and cooling. For each model, we check whether gravity governs the flow properties, by computing and analyzing the volume-integrated quantities that appear in the virial theorem: internal, kinetic, and gravitational energies, We find that in the first two models, the winds are non-virialized whereas the two line-driven disk winds are virialized up to a relatively large distance. The line-driven winds are virialized because they accelerate slowly so that the rotational velocity is dominant and the wind base is very dense. For the two virialized winds, the so-called projected virial factor scales with inclination angle as $1/ \sin^2{i}$. Finally, we demonstrate that an outflow from a Keplerian disk becomes unvirialized more slowly when it conserves the gas specific angular momentum -- as in the models considered here, than when it conserves the angular velocity -- as in the so-called magneto-centrifugal winds.Comment: Accepted to Ap

Experimental Evidence for a Metallohydrolase Mechanism in Which the Nucleophile Is Not Delivered by a Metal Ion: EPR Spectrokinetic and Structural Studies of Aminopeptidase from \u3cem\u3eVibrio proteolyticus\u3c/em\u3e

Metallohydrolases catalyse some of the most important reactions in biology and are targets for numerous chemotherapeutic agents designed to combat bacterial infectivity, antibiotic resistance, HIV infectivity, tumour growth, angiogenesis and immune disorders. Rational design of inhibitors of these enzymes with chemotherapeutic potential relies on detailed knowledge of the catalytic mechanism. The roles of the catalytic transition ions in these enzymes have long been assumed to include the activation and delivery of a nucleophilic hydroxy moiety. In the present study, catalytic intermediates in the hydrolysis of L-leucyl-L-leucyl-L-leucine by Vibrio proteolyticus aminopeptidase were characterized in spectrokinetic and structural studies. Rapid-freeze-quench EPR studies of reaction products of L-leucyl-L-leucyl-L-leucine and Co(II)-substituted aminopeptidase, and comparison of the EPR data with those from structurally characterized complexes of aminopeptidase with inhibitors, indicated the formation of a catalytically competent post-Michaelis pre-transition state intermediate with a structure analogous to that of the inhibited complex with bestatin. The X-ray crystal structure of an aminopeptidase–L-leucyl-L-leucyl-L-leucine complex was also analogous to that of the bestatin complex. In these structures, no water/hydroxy group was observed bound to the essential metal ion. However, a water/hydroxy group was clearly identified that was bound to the metal-ligating oxygen atom of Glu152. This water/hydroxy group is proposed as a candidate for the active nucleophile in a novel metallohydrolase mechanism that shares features of the catalytic mechanisms of aspartic proteases and of B2 metallo-b-lactamases. Preliminary studies on site-directed variants are consistent with the proposal. Other features of the structure suggest roles for the dinuclear centre in geometrically and electrophilically activating the substrate

Dentition Status and its effect on the Oral Health Related Quality of Life in a Rural Elderly Population: A Cross Sectional Study

Background: This study was conducted to find out the effect of dentition status on the oral health related quality of life of rural elderly people residing in an Indian population.Methods: A total of 368 elderly subjects from eight villages were included in the study. OHRQoL was measured by using a validated Hindi version of Geriatric Oral Health AsBackground: This study was conducted to find out the effect of dentition status on the oral health related quality of life (OHRQoL) of rural elderly people in an Indian population. The main objectives included the assessment of age wise differences among the elderly segment, particularly the effect of coronal and root caries, missing teeth and filled teeth.Methods: A total of 368 (192 (52.17%) males and 176 (47.83%) females) elderly subjects from eight villages were included in the study. Oral Health Related Quality of life was measured by using a validated Hindi version of Geriatric Oral Health Assessment Index (GOHAI). Clinical assessment of the subjects was done regarding carious, missing, and filled teeth, and carious roots.Results: The mean GOHAI score was found to be 18.14 ± 5.71. The mean number of decayed crown was 1.34 ± 1.63, mean number of missing teeth was 12.74 ± 11.14, mean DMFT score was 14.08 ± 10.13, and mean number of teeth with root caries was 0.55 ± 1.17. Average number of carious roots was found to be maximum among 70-79 years age group followed by 60-69 years age group. Age wise differences were found to be statistically significant for mean number of decayed crown, missing teeth, root caries and mean DMFT.Conclusion: The results revealed that having more teeth present and less decayed teeth were found to be associated with better oral health related quality of life. The elderly are a special part of our society and need the utmost attention since they are most susceptible to oral diseases which impact their daily activities. Hence more light needs to be thrown on such issues to improve the overall health including the oral component.sessment Index (GOHAI). Clinical assessment of the subjects was done regarding carious, missing, filled teeth and carious roots.Results: The mean GOHAI score was found to be 18.14 ± 5.71. The mean decayed teeth were found to be 1.34 and mean DMFT was 14.08. Age wise differences were found to be statistically significant for mean number of decayed crown, missing teeth, root caries and mean DMFT.Conclusion: The results revealed the having more teeth present and less decayed teeth were found to be associated with better oral health related quality of life

Knotted Floss Technique

Whenever a patient finds gingival embrasures that are too wide for use of a regular dental floss and too thin for insertion of an interdental brush, a dental floss can be modified by tying a simple knot on it and using the knotted area for hygiene of such wide Type-I gingival embrasure

DataHub: Collaborative Data Science & Dataset Version Management at Scale

Relational databases have limited support for data collaboration, where teams collaboratively curate and analyze large datasets. Inspired by software version control systems like git, we propose (a) a dataset version control system, giving users the ability to create, branch, merge, difference and search large, divergent collections of datasets, and (b) a platform, DataHub, that gives users the ability to perform collaborative data analysis building on this version control system. We outline the challenges in providing dataset version control at scale.Comment: 7 page

Influence of Basis-set Size on the X\u3csup\u3e2\u3c/sup\u3eΣ\u3csup\u3e+\u3c/sup\u3e\u3csub\u3e1/2\u3c/sub\u3e, A\u3csup\u3e2\u3c/sup\u3eΠ\u3csub\u3e1/2\u3c/sub\u3e, A\u3csup\u3e2\u3c/sup\u3eΠ\u3csub\u3e3/2\u3c/sub\u3e, and B\u3csup\u3e2\u3c/sup\u3eΣ\u3csub\u3e1/2\u3c/sub\u3e potential-energy curves, A\u3csup\u3e2\u3c/sup\u3eΠ\u3csub\u3e3/2\u3c/sub\u3e 2 vibrational energies, and D\u3csub\u3e1\u3c/sub\u3e and D\u3csub\u3e2\u3c/sub\u3e line shapes of Rb+He

The X 2 Σ + 1 / 2 , A 2 Π 1 / 2 , A 2 Π 3 / 2 , and B 2 Σ + 1 / 2 potential-energy curves for Rb+He are computed at the spin-orbit multireference configuration interaction level of theory using a hierarchy of Gaussian basis sets at the double-zeta (DZ), triple-zeta (TZ), and quadruple-zeta (QZ) levels of valence quality. Counterpoise and Davidson-Silver corrections are employed to remove basis-set superposition error and ameliorate size-consistency error. An extrapolation is performed to obtain a final set of potential-energy curves in the complete basis-set (CBS) limit. This yields four sets of systematically improved X 2 Σ + 1 / 2 , A 2 Π 1 / 2 , A 2 Π 3 / 2 , and B 2 Σ + 1 / 2 potential-energy curves that are used to compute the A 2 Π 3 / 2 bound vibrational energies, the position of the D 2 blue satellite peak, and the D 1 and D 2 pressure broadening and shifting coefficients, at the DZ, TZ, QZ, and CBS levels. Results are compared with previous calculations and experimental observation

Use of a Noninvasive Continuous Monitoring Device in the Management of Atrial Fibrillation: A Pilot Study

Background: Outpatient ambulatory cardiac rhythm monitoring is a routine part of the management of patients with paroxysmal atrial fibrillation (AF). Current systems are limited by patient convenience and practicality. Methods: We compared the Zio® Patch, a single-use, noninvasive waterproof long-term continuous monitoring patch, with a 24-hour Holter monitor in 74 consecutive patients with paroxysmal AF referred for Holter monitoring for detection of arrhythmias. Results: The Zio® Patch was well tolerated, with a mean monitoring period of 10.8 ± 2.8 days (range 4–14 days). Over a 24-hour period, there was excellent agreement between the Zio® Patch and Holter for identifying AF events and estimating AF burden. Although there was no difference in AF burden estimated by the Zio® Patch and the Holter monitor, AF events were identified in 18 additional individuals, and the documented pattern of AF (persistent or paroxysmal) changed in 21 patients after Zio® Patch monitoring. Other clinically relevant cardiac events recorded on the Zio® Patch after the first 24 hours of monitoring, including symptomatic ventricular pauses, prompted referrals for pacemaker placement or changes in medications. As a result of the findings from the Zio® Patch, 28.4% of patients had a change in their clinical management. Conclusions: The Zio® Patch was well tolerated, and allowed significantly longer continuous monitoring than a Holter, resulting in an improvement in clinical accuracy, the detection of potentially malignant arrhythmias, and a meaningful change in clinical management. Further studies are necessary to examine the long-term impact of the use of the Zio® Patch in AF management

External cortical landmarks and measurements for the temporal horn: Anatomic study with application to surgery of the temporal lobe

BACKGROUND: The location of the temporal horn is important to neurosurgeons during procedures such as amygdalohippocampectomy and intraventricular electrode placement for temporal lobe seizure monitoring. However, sometimes the temporal horn is difficult to localize, especially without neuronavigation. The authors aimed to better localize this structure using superficial anatomic landmarks. METHODS: Twenty-two brain halves were dissected from the midline, and the fornix identified and followed toward the left and right temporal horns. Once the temporal horn was isolated from a mesial approach, 6-cm long needles were placed into its anterior and posterior walls of the temporal horn and passed laterally from the axial plane to the cortical surface. Pin exit sites were marked externally and measurements taken between the outer temporal lobe cortex and the underlying temporal horn. RESULTS: No statistical differences were noted between left and right sides. The temporal horn was generally directed anteroinferiorly and best marked externally by the inferior temporal sulcus. The mean length of the temporal horn was 4.4 cm. Mean distance from anterior temporal tip to anterior wall of the temporal horn was 3.3 cm. The mean distance from the anterior temporal tip to the posterior wall of the temporal horn was 7 cm. The anterior wall of the temporal horn was a mean of 3 mm superior to the inferior temporal sulcus. The posterior wall was a mean of 1.2 cm superior to the inferior temporal sulcus. CONCLUSIONS: These landmarks and measurements may help neurosurgeons better localize this part of the lateral ventricular system

Manganese-catalysed synthesis of polyketones using hydrogen-borrowing approach

Funding: Engineering and Physical Sciences Research Council - EP/R023751/1, EP/T019298/1, EP/L017008/1; UK Research and Innovation - MR/W007460/1.We report here a method of making polyketones from the coupling of diketones and diols using a manganese pincer complex. The methodology allows us to access various polyketones (polyarylalkylketone) containing aryl, alkyl, and ether functionalities, bridging the gap between the two classes of commercially available polyketones: aliphatic polyketones and polyaryletherketones. Using this methodology, 12 polyketones have been synthesized and characterized using various analytical techniques to understand their chemical, physical, morphological, and mechanical properties. Based on previous reports and our studies, we suggest that the polymerization occurs via a hydrogen-borrowing mechanism that involves the dehydrogenation of diols to dialdehyde followed by aldol condensation of dialdehyde with diketones to form chalcone derivatives and their subsequent hydrogenation to form polyarylalkylketones.Peer reviewe