Forward-Backward Correlations and Event Shapes as probes of Minimum-Bias Event Properties

Measurements of inclusive observables, such as particle multiplicities and momentum spectra, have already delivered important information on soft-inclusive ("minimum-bias") physics at the Large Hadron Collider. In order to gain a more complete understanding, however, it is necessary to include also observables that probe the structure of the studied events. We argue that forward-backward (FB) correlations and event-shape observables may be particulary useful first steps in this respect. We study the sensitivity of several different types of FB correlations and two event shape variables - transverse thrust and transverse thrust minor - to various sources of theoretical uncertainty: multiple parton interactions, parton showers, colour (re)connections, and hadronization. The power of each observable to furnish constraints on Monte Carlo models is illustrated by including comparisons between several recent, and qualitatively different, PYTHIA 6 tunes, for pp collisions at sqrt(s) = 900 GeV.Comment: 13 page

Retrieval, reuse, revision and retention in case-based reasoning

El original está disponible en www.journals.cambridge.orgCase-based reasoning (CBR) is an approach to problem solving that emphasizes the role of prior experience during future problem solving (i.e., new problems are solved by reusing and if necessary adapting the solutions to similar problems that were solved in the past). It has enjoyed considerable success in a wide variety of problem solving tasks and domains. Following a brief overview of the traditional problem-solving cycle in CBR, we examine the cognitive science foundations of CBR and its relationship to analogical reasoning. We then review a representative selection of CBR research in the past few decades on aspects of retrieval, reuse, revision, and retention.Peer reviewe

Stroke genetics informs drug discovery and risk prediction across ancestries

Previous genome-wide association studies (GWASs) of stroke — the second leading cause of death worldwide — were conducted predominantly in populations of European ancestry1,2. Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-European) and 1,503,898 control individuals, we identify association signals for stroke and its subtypes at 89 (61 new) independent loci: 60 in primary inverse-variance-weighted analyses and 29 in secondary meta-regression and multitrait analyses. On the basis of internal cross-ancestry validation and an independent follow-up in 89,084 additional cases of stroke (30% non-European) and 1,013,843 control individuals, 87% of the primary stroke risk loci and 60% of the secondary stroke risk loci were replicated (P < 0.05). Effect sizes were highly correlated across ancestries. Cross-ancestry fine-mapping, in silico mutagenesis analysis3, and transcriptome-wide and proteome-wide association analyses revealed putative causal genes (such as SH3PXD2A and FURIN) and variants (such as at GRK5 and NOS3). Using a three-pronged approach4, we provide genetic evidence for putative drug effects, highlighting F11, KLKB1, PROC, GP1BA, LAMC2 and VCAM1 as possible targets, with drugs already under investigation for stroke for F11 and PROC. A polygenic score integrating cross-ancestry and ancestry-specific stroke GWASs with vascular-risk factor GWASs (integrative polygenic scores) strongly predicted ischaemic stroke in populations of European, East Asian and African ancestry5. Stroke genetic risk scores were predictive of ischaemic stroke independent of clinical risk factors in 52,600 clinical-trial participants with cardiometabolic disease. Our results provide insights to inform biology, reveal potential drug targets and derive genetic risk prediction tools across ancestries

Useful identities for half-space problems in linear transport theory

A typical translationally invariant linear transport problem for a half-space is solved by the eigenfunction method. Using some derived identities for the solution of the associated homogeneous Hilbert problem it is shown that the usual cumbersome integrals occurring in half-space problems can be reduced to a simple form. The usefulness of the identities is illustrated by solving the problem of a plasma confined to a half-space by a diffuse reflecting wall.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/32239/1/0000301.pd

reasoning

Retrieval, reuse, revision, and retention in casebase