On and off the beaten path: How individuals broker knowledge through formal and informal networks

Although informal networks are often emphasized as facilitating knowledge transfer, we use network data obtained from a multi-unit high-tech firm to show that the formal network also significantly contributes to inter-unit knowledge transfer. Individuals centrally placed in a network are, in addition, more involved in knowledge transfer, especially, the evidence suggests, in the case of the formal network. Focusing on the brokerage roles that individual fulfill, we find that knowledge transfer between units is more likely to occur through externally oriented brokers than internally oriented brokers in the formal network, but not in the informal network. Overall, the results show that there is more than one path to transfer knowledge

Molecular and immunological characterization of profilin from mugwort pollen

In late summer in Europe, pollen of mugwort is one of the major sources of atopic allergens. No information about the complete molecular structure of any mugwort allergen has been published so far. Here we report the isolation and characterization of mugwort pollen cDNA clones coding for two isoforms of the panallergen profilin. Thirtysix percent of the mugwort allergic patients tested displayed IgE antibodies against natural and recombinant profilin, and no significant differences were observed in the IgEbinding properties of the isoforms. One profilin isoform was purified to homogeneity and detailed structural analysis indicated that the protein exists in solution as dimers and tetramers stabilized by sulfydryl and/or ionic interactions. Profilin monomers were detectable only after exposure of multimers to harsh denaturing conditions. Dimers and tetramers did not significantly differ in their ability to bind serum IgE from mugwort pollenallergic patients. However, oligomeric forms might have a higher allergenic potential than monomers because larger molecules would have additional epitopes for IgEmediated histamine release. Profilin isolated from mugwort pollen also formed multimers. Thus, oligomerization is not an artifact resulting from the recombinant production of the allergen. Inhibition experiments showed extensive IgE crossreactivity of recombinant mugwort profilin and profilin from various pollen and food extracts

PHYSICAL ACTIVITY AND COGNITIVE FUNCTION OF LONG DISTANCE WALKERS: STUDYING FOUR DAYS MARCHES PARTICIPANTS.

OBJECTIVE: Studies show physical activity to be beneficial for cognitive function. However, studies usually included individuals who were not particularly inclined to exercise. Following research among master athletes, we examined associations between physical activity and cognitive function in participants of the International Nijmegen Four Days Marches. These individuals are also inclined to exercise. On 4 consecutive days > 40,000 participants walk a daily distance of 30-50 km (120-200 km or 75-125 miles in total). METHOD: Four Days Marches participants and less active or inactive control participants from the Nijmegen Exercise Study were examined. Self-reported current and lifelong physical activities were quantified in Metabolic Equivalent of Task minutes/day and training walking speed was estimated in km/h. Cognitive functioning in the domains of working memory, executive function, and visuospatial short-term memory was assessed using the validated Brain Aging Monitor. RESULTS: Data from 521 participants (mean age 54.7, standard deviation 12.9) showed neither positive associations between lifelong physical activity and working memory, executive function, and visuospatial short-term memory nor positive associations between current physical activity and cognitive functioning in these domains (P-values > 0.05). However, a positive association between training walking speed and working memory was revealed (age adjusted Beta = 0.18, P-value < 0.01). CONCLUSION: Walking speed, as a surrogate marker of fitness, but not lifelong and current physical activity levels were associated with cognitive function. Therefore, walking speed deserves more attention in research aimed at unravelling associations between physical activity and cognitive function

Betere risicospreiding van eigen bijdragen bij verpleeghuiszorg

Ouderen betalen een eigen bijdrage voor het gebruik van verpleeghuiszorg. De hoogte van de eigen bijdrage hangt af van iemands financiële middelen, maar inkomen en vermogen worden verschillend belast. Voor ouderen vormt de eigen bijdrage een aanzienlijk financieel risico. Zo kunnen de jaarlijkse kosten voor langdurige verpleeghuiszorg voor ouderen met een middeninkomen oplopen tot ruim 70% van het netto-inkomen en vele jaren duren

De politiek van buy-to-let

Mounting concerns exist that small private investors exacerbate the urban housing crisis, by purchasing dwellings to rent out so-called ‘buy-to-let’ purchases. By buying up property, they may drive up house prices and exclude regular house-seekers. In this paper, we show that buy-to-let purchases constitute an increasing share of all purchases on the Dutch housing market, and especially so in larger cities and university cities. We argue these local trends do not emerge out of thin air and are not a ‘natural’ market process but should be considered the product of both global economic developments and national policies supporting these changes. Global developments include the increased mobility and ample availability of capital, exemplified by a prolonged low interest environment and a growing scarcity of high quality collateral and investment opportunities, making housing attractive for storing capital. Dutch housing policies have increasingly restricted access to social rent to low-income groups, while blowing up house prices fuelled with mortgage debts. As a consequence, a growing number of households falls in-between these two tenures: they have to resort to private rent. Private investors respond to and accommodate this demand through buy-to-let investments. Furthermore, the Dutch national government has made steps to relax regulation on the private-rental market and weakened tenant rights. In so doing, it sets the scene for amplifying social and spatial inequalities between the property rich and the property poor