Mental health, pain and tiredness in adults born very preterm or with very low birthweight

Aim: Adults born preterm have increased risk of mental health problems and other neurodevelopmental conditions. We aimed to investigate associations of mental health with pain and tiredness in adults born very preterm (VP; <32 weeks) or very low birthweight (VLBW; <1500 g) and at term, and whether these associations are influenced by physical activity. Methods: As part of an EU Horizon 2020 project, individual participant data from six prospective cohort studies were harmonised for 617 VP/VLBW and 1122 term‐born participants. Mental health was assessed by the Achenbach System of Empirically Based Assessment Adult Self‐Report. Pain and tiredness were harmonised based on specific items from self‐reported questionnaires. Associations between mental health and pain or tiredness were explored by linear regression. Results: An increase in the mental health scales internalising, externalising and total problems was associated with increased pain and tiredness in the preterm and term group alike. Results were maintained when adjusting for physical activity. Conclusion: The findings indicate that associations between mental health, pain and tiredness in adults are independent of gestation or birthweight. Future research should explore other potential mechanisms that may underlie the increased risk of mental health problems in the preterm population

Physical activity and life satisfaction among older adults in HUNT4 Trondheim 70+

Bakgrunn: Flere studier har vist at fysisk og mental helse er sterkt relatert til hverandre, og interessen for denne relasjonen har stadig økt de siste årene. Selv om flere studier har vist at fysisk aktivitet kan være assosiert med livskvalitet blant eldre, har de fleste studier i hovedsak undersøkt de friskeste eldre eller eldre i utvalgte aldersgrupper. De eldste og mest sårbare eldre har ofte blitt utelatt fra studier på grunn av høy forekomst av aldersrelaterte sykdommer. Som et resultat av dette har vi lite kunnskap om den eldre befolkningen som helhet. Gjennom Helseundersøkelsen i Trøndelag ønsket man derfor å se nærmere på bredden av den eldre befolkningen gjennom understudien HUNT4 Trondheim 70+. Helsedata som er tilgjengelig i denne studien gjør det mulig å undersøke sammenhengen mellom fysisk aktivitet og livskvalitet blant eldre. Forskningsspørsmål: Det ble valgt to forskningsspørsmål for denne studien: 1. Hva kjennetegner deltagerne i HUNT4 Trondheim 70+? og 2. Hva er sammenhengen mellom fysisk aktivitet og livskvalitet blant eldre? Design: Populasjonsbasert tverrsnittstudie av helsedata. Metode: 1749 eldre deltok i HUNT4 Trondheim 70+ (1011 kvinner og 738 menn, 78.6±7 år). Datainnsamlingen bestod av spørreskjema, kliniske målinger, intervjuer, test av fysisk funksjon, kognitiv funksjon og registrering av aktivitetsdata. Fysisk aktivitet (FA) ble målt objektivt gjennom en uke, og utfallsmålet var antall steg på den mest aktive dagen i løpet av perioden. Livskvalitet ble målt subjektivt gjennom spørreskjema. Sammenhengen mellom fysisk aktivitet og livskvalitet ble undersøkt blant de deltagerne med rapporterte verdier på alle relevante variabler (n=957). Sammenhengen ble testet ved en logistisk regresjonsanalyse med justeringsmodeller. Resultat: Deltagerne i HUNT4 Trondheim 70+ varierte i helsetilstand, alder og funksjon. Deltagerne var mellom 70-105 år og hadde et aktivitetsnivå som strekte seg fra 9-42 500 steg på den mest aktive dagen i løpet av perioden. Blant deltagerne som ble inkludert i regresjonsanalysen hadde deltagerne i den nest mest aktive gruppen 73% høyere odds for å rapportere god livskvalitet sammenlignet med deltagerne som var minst fysisk aktive. Test for lineær trend var statistisk signifikant for 2 av de tre modellene. Konklusjon: Funnene i regresjonsanalysen viste at deltagerne med høyere aktivitetsnivå rapporterte bedre livskvalitet enn deltagerne som var mindre fysisk aktive

Physical activity and associations with health-related quality of life in adults born small for gestational age at term : a prospective cohort study

Background Adults born small for gestational age (SGA) have increased risk of adverse health outcomes. Physical activity (PA) is a key determinant of health and health-related quality of life (HRQoL). We aimed to investigate if being born SGA at term is associated with lower objectively measured and self-reported PA during adulthood. We also examined if objectively measured and self-reported PA were associated with HRQoL.Methods As part of the 32-year follow-up in the NTNU Low Birth Weight in a Lifetime Perspective study, SGA and non-SGA control participants wore two tri-axial accelerometers for seven days (37 SGA, 43 control), and completed the International Physical Activity Questionnaire (IPAQ) (42 SGA, 49 control) and the Short Form 36 Health Survey (SF-36) (55 SGA, 67 control). Group differences in objectively measured daily metabolic equivalent of task (MET) minutes spent sedentary (lying, sitting), on feet (standing, walking, running, cycling), on the move (walking, running, cycling) and running/cycling, and group differences in self-reported daily MET minutes spent walking and in moderate and vigorous PA were examined using linear regression. Associations with SF-36 were explored in a general linear model.Results Mean (SD) daily MET minutes on the move were 218 (127) in the SGA group and 227 (113) in the control group. There were no group differences in objectively measured and self-reported PA or associations with HRQoL. In the SGA group, one MET minute higher objectively measured time on the move was associated with 4.0 (95% CI: 0.6-6.5, p = 0.009) points higher SF-36 physical component summary.Conclusion We found no differences in objectively measured and self-reported PA or associations with HRQoL between term-born SGA and non-SGA control participants in adulthood.Peer reviewe

Physical activity and associations with health-related quality of life in adults born small for gestational age at term:a prospective cohort study

Abstract Background: Adults born small for gestational age (SGA) have increased risk of adverse health outcomes. Physical activity (PA) is a key determinant of health and health-related quality of life (HRQoL). We aimed to investigate if being born SGA at term is associated with lower objectively measured and self-reported PA during adulthood. We also examined if objectively measured and self-reported PA were associated with HRQoL. Methods: As part of the 32-year follow-up in the NTNU Low Birth Weight in a Lifetime Perspective study, SGA and non-SGA control participants wore two tri-axial accelerometers for seven days (37 SGA, 43 control), and completed the International Physical Activity Questionnaire (IPAQ) (42 SGA, 49 control) and the Short Form 36 Health Survey (SF-36) (55 SGA, 67 control). Group differences in objectively measured daily metabolic equivalent of task (MET) minutes spent sedentary (lying, sitting), on feet (standing, walking, running, cycling), on the move (walking, running, cycling) and running/cycling, and group differences in self-reported daily MET minutes spent walking and in moderate and vigorous PA were examined using linear regression. Associations with SF-36 were explored in a general linear model. Results: Mean (SD) daily MET minutes on the move were 218 (127) in the SGA group and 227 (113) in the control group. There were no group differences in objectively measured and self-reported PA or associations with HRQoL. In the SGA group, one MET minute higher objectively measured time on the move was associated with 4.0 (95% CI: 0.6–6.5, p = 0.009) points higher SF-36 physical component summary. Conclusion: We found no differences in objectively measured and self-reported PA or associations with HRQoL between term-born SGA and non-SGA control participants in adulthood

Physical activity and cognitive function in adults born very preterm or with very low birth weight–an individual participant data meta-analysis

Objective Individuals born very preterm (<32 weeks of gestation) or with very low birthweight (<1500g) have lower cognitive function compared with term-born peers. Furthermore, some studies suggest that they are less physically active as young adults than controls, but the relationship between physical activity and cognitive function remains unclear. We performed an individual participant data meta-analysis to examine whether being born preterm/with very low birth weight is associated with physical activity in adulthood and examined if cognitive function mediates this association. Study design Cohorts with data on physical activity and cognitive function in adults born very preterm/very low birth weight and term-born controls were recruited from the Research on European Children and Adults Born Preterm, and the Adults Born Preterm International Collaboration Consortia. A systematic literature search was performed in PubMed and Embase. Results Five cohorts with 1644 participants aged 22–28 years (595 very preterm/very low birth weight and 1049 controls) were included. Adults born very preterm/very low birth weight reported 1.11 (95% CI: 0.68 to 1.54) hours less moderate to vigorous physical activity per week than controls, adjusted for cohort, age and sex. The difference between individuals born very preterm/very low birth weight and controls was larger among women than among men. Neither intelligence quotient nor self-reported executive function mediated the association between very preterm/very low birth weight and moderate to vigorous physical activity. Results were essentially the same when we excluded individuals with neurosensory impairments. Conclusion Adults born very preterm/very low birth weight, especially women, reported less moderate to vigorous physical activity than their term-born peers. Cognitive function did not mediate this association. Considering the risk of adverse health outcomes among individuals born preterm, physical activity could be a target for intervention.Peer reviewe