122,624 research outputs found
B mu G@Sbase - a microarray database and analysis tool
The manufacture and use of a whole-genome microarray is a complex process and it is essential that all data surrounding the process is stored, is accessible and can be easily associated with the data generated following hybridization and scanning. As part of
a program funded by the Wellcome Trust, the Bacterial Microarray Group at St.
George's Hospital Medical School (BμG@S) will generate whole-genome microarrays
for 12 bacterial pathogens for use in collaboration with specialist research groups.
BμG@S will collaborate with these groups at all levels, including the experimental
design, methodology and analysis. In addition, we will provide informatic support
in the form of a database system (BμG@Sbase). BμG@Sbase will provide access
through a web interface to the microarray design data and will allow individual
users to store their data in a searchable, secure manner. Tools developed by BμG@S
in collaboration with specific research groups investigating analysis methodology will
also be made available to those groups using the arrays and submitting data to
BμG@Sbase
Equivalent air spring suspension model for quarter-passive model of passenger vehicles
This paper investigates the GENSIS air spring suspension system equivalence to a passive suspension system. The SIMULINK simulation together with the OptiY optimization is used to obtain the air spring suspension model equivalent to passive suspension system, where the car body response difference from both systems with the same road profile inputs is used as the objective function for optimization (OptiY program). The parameters of air spring system such as initial pressure, volume of bag, length of surge pipe, diameter of surge pipe, and volume of reservoir are obtained from optimization. The simulation results show that the air spring suspension equivalent system can produce responses very close to the passive suspension system
Coverage, Matching, and Beyond: New Results on Budgeted Mechanism Design
We study a type of reverse (procurement) auction problems in the presence of
budget constraints. The general algorithmic problem is to purchase a set of
resources, which come at a cost, so as not to exceed a given budget and at the
same time maximize a given valuation function. This framework captures the
budgeted version of several well known optimization problems, and when the
resources are owned by strategic agents the goal is to design truthful and
budget feasible mechanisms, i.e. elicit the true cost of the resources and
ensure the payments of the mechanism do not exceed the budget. Budget
feasibility introduces more challenges in mechanism design, and we study
instantiations of this problem for certain classes of submodular and XOS
valuation functions. We first obtain mechanisms with an improved approximation
ratio for weighted coverage valuations, a special class of submodular functions
that has already attracted attention in previous works. We then provide a
general scheme for designing randomized and deterministic polynomial time
mechanisms for a class of XOS problems. This class contains problems whose
feasible set forms an independence system (a more general structure than
matroids), and some representative problems include, among others, finding
maximum weighted matchings, maximum weighted matroid members, and maximum
weighted 3D-matchings. For most of these problems, only randomized mechanisms
with very high approximation ratios were known prior to our results
Multiscale molecular simulations of the formation and structure of polyamide membranes created by interfacial polymerization
Large scale molecular simu lations to model the formation of polyamide membranes have been carried out using a procedure that mimics experimental interfacial polymerization of trimesoyl chloride (TMC) and metaphenylene diamine (MPD) monomers. A coarse - grained representation of the m onomers has been developed to facilitate these simulations, which captures essential features of the stereochemistry of the monomers and of amide bonding between them. Atomic models of the membranes are recreated from the final coarse - grained representatio ns. Consistent with earlier treatments, membranes are formed through the growth and aggregation of oligomer clusters. The membranes are inhomogeneous, displaying opposing gradients of trapped carboxyl and amine side groups, local density variations, and r egions where the density of amide bonding is reduced as a result of the aggregation process. We observe the interfacial polymerization reaction is self - limiting and the simulated membranes display a thickness of 5 – 10 nm. They also display a surface roughn ess of 1 – 4 nm. Comparisons are made with recently published experimental results on the structure and chemistry of these membranes and some interesting similarities and differences are found
New Neighbours: Modelling the Growing Population of Gamma-ray Millisecond Pulsars
The Fermi Large Area Telescope, in collaboration with several groups from the
radio community, have had marvellous success at uncovering new gamma-ray
millisecond pulsars (MSPs). In fact, MSPs now make up a sizable fraction of the
total number of known gamma-ray pulsars. The MSP population is characterized by
a variety of pulse profile shapes, peak separations, and radio-to-gamma phase
lags, with some members exhibiting nearly phase-aligned radio and gamma-ray
light curves (LCs). The MSPs' short spin periods underline the importance of
including special relativistic effects in LC calculations, even for emission
originating from near the stellar surface. We present results on modelling and
classification of MSP LCs using standard pulsar model geometries.Comment: 4 pages, 2 figures, proceedings of the ICREA Workshop on The
High-Energy Emission from Pulsars and their Systems (HEEPS), Sant Cugat,
Spai
Helicity at Photospheric and Chromospheric Heights
In the solar atmosphere the twist parameter has the same sign as
magnetic helicity. It has been observed using photospheric vector magnetograms
that negative/positive helicity is dominant in the northern/southern hemisphere
of the Sun. Chromospheric features show dextral/sinistral dominance in the
northern/southern hemisphere and sigmoids observed in X-rays also have a
dominant sense of reverse-S/forward-S in the northern/southern hemisphere. It
is of interest whether individual features have one-to-one correspondence in
terms of helicity at different atmospheric heights. We use UBF \Halpha images
from the Dunn Solar Telescope (DST) and other \Halpha data from Udaipur Solar
Observatory and Big Bear Solar Observatory. Near-simultaneous vector
magnetograms from the DST are used to establish one-to-one correspondence of
helicity at photospheric and chromospheric heights. We plan to extend this
investigation with more data including coronal intensities.Comment: 5 pages, 1 figure, 1 table To appear in "Magnetic Coupling between
the Interior and the Atmosphere of the Sun", eds. S.S. Hasan and R.J. Rutten,
Astrophysics and Space Science Proceedings, Springer-Verlag, Heidelberg,
Berlin, 200
Stem Cells and Liver Disease
Liver transplantation is the primary treatment for various end-stage hepaticdiseases but is hindered by the lack of donor organs, complications associated with rejection and immunosuppression. An increasingly unbridgeable gap exists between the supply and demand of transplantable organs. Hence stem cell research and regenerative medicine have the potential to revolutionize the future of medicine with the ability toregenerate damaged and diseased organs. Stem cells serving as a repair system for the body, can theoretically divide without limit to replenish other cells. These cells could relieve the symptoms of liver disease or the genetic error could potentially be corrected by gene therapy. In cases of acute liver failure in adults, stem cell therapies might be used to support the liver, allowing it time to recover
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