Evaluation of the adjunctive effect of platelet-rich fibrin to enamel matrix derivative in the treatment of intrabony defects. Six-month results of a randomized, split-mouth, controlled clinical study

Dolgun, Anil Barak/0000-0002-2693-0666WOS: 000388359000009PubMed: 27396428Aim: This study aimed to compare the results obtained with enamel matrix derivative (EMD) and EMD + platelet-rich fibrin (PRF) in the treatment of intrabony defects (IBDs) in chronic periodontitis patients. Materials and Methods: Using a split-mouth design, 28 paired IBDs were randomly treated either with EMD or with EMD + PRF. Clinical and radiographic measurements including clinical attachment level (CAL), probing depth (PD), gingival recession (GR), defect depth (DD), defect width (DW) and defect angle (DA) were recorded at baseline (BL) and at six months following therapy. Results: BL clinical and radiographic measurements were similar for EMD and EMD + PRF groups. Although postsurgical measurements revealed significant reduction for PD and CAL in both groups, no intergroup difference was detected. When EMD and EMD + PRF groups were compared, defect fill was not also statistically different. Conclusions: Both therapies resulted in significant clinical improvement in IBD treatment. Addition of PRF did not improve the clinical and radiographic outcomes

Tıbbi Uygulama Hatası Riski Yüksek Olan Uzmanlık Dallarının Tıpta Uzmanlık Sınavında Tercih Edilme Önceliklerinin Yıllara Göre Değişimi

Giriş-Amaç: Hekimlerin, hukuka aykırı ve/veya kusurlu tıbbi müdahale ve tedavilerinden dolayı hastalığın normal seyrinin dışına çıkması, iyileşmesinin gecikmesi, hastanın ölümüne neden olması tıbbi uygulama hatası olarak tanımlanmaktadır. Tıbbi uygulama hatası iddiasıyla hekimlere karşı açılan gerek ceza gerekse tazminat davalarındaki artışlar, hekimleri defansif tıp uygulamaya yöneltmiştir. Defansif tıbbın, Tıpta Uzmanlık Sınavına yansıması ise; daha düşük riskli uzmanlık dallarının öncelikle tercih edilmesi olmaktadır. Gereç-Yöntem: Bu çalışmada, 2010 yılında yürürlüğe giren Tıbbi Kötü Uygulamaya İlişkin Zorunlu Mali Sorumluluk Sigortası’ kapsamında risk grupları belirlenen uzmanlık dallarının, yıllar içerisinde hekimler tarafından tercih edilme önceliklerindeki değişimin gösterilmesi amaçlanmıştır. Bu sigorta kapsamında, risk düzeyi en yüksek 4. grup, en düşük risk grubu ise 1. grup olarak belirlenmiştir. Bulgular: 2009-2013 yılları arasındaki Tıpta Uzmanlık Sınavı (TUS) yerleştirme sonuçlarına göre uzmanlık dallarının ülke genelindeki taban puanları, çalışmaya dahil edilmiştir. 2009’dan 2013’e gelinen süreçte, 2. grubun taban puanlarının giderek arttığı, 3. grubun sabitkaldığı, 4. grubun ise anlamlı derecede düştüğü saptanmıştır. Sonuç: Hekimlerin önceliklerinin değişmesinde, son yıllarda hekime yönelik şiddet olaylarındaki artışın yanı sıra, tıbbi uygulama hataları riskinin diğer gruplara göre daha yüksek olması, dolayısıyla açılan dava sayılarının ve hükmedilen tazminat miktarlarının giderek artmasına karşın hekimlerin aldıkları riskle orantılı olarak kazançlarının artmaması olduğu kanaatine varılmıştır. Hekimler arasında defansif tıp uygulamalarının gün geçtikçe arttığı tartışılırken, yapılan bu çalışmada bu durumun uzman hekim adaylarının tercihlerine bile yansıdığı görülmektedir. Anahtar kelimeler: Tıbbi uygulama hatası, Defansif tıp, Tıpta uzmanlık sınavı

The effects of chemotherapeutic agents on differentiated chordoma cells

Object. Chordoma is a rare type of malignant bone tumor and is known to arise from the remnants of the notochord. Resistance to chemotherapy makes the treatment of chordoma difficult; therefore, new approaches need to be developed to cure this disease. Differentiation therapy, using various differentiating agents, is attracting oncologists as a common therapeutic method to treat other tumors. Based on forcing cells to mature into other lineages, differentiation therapy might be an available method to treat chordomas in addition to conventional therapies

Clonal diversity and antifungal susceptibility of Candida spp. recovered from cow milk

The aim of this study was the isolation, identification, phylogenetic analysis and antifungal susceptibility of Candida spp. from milk samples of healthy and mastitic cows in Kayseri/Turkey. Milk samples from 300 cows were found to be negative/positive for mastitis with the California Mastitis Test. Candida spp. was isolated by using the Brillance Candida Agar Base. Phenotypic tests, Matrix Assisted Laser Desorption Ionization - Time of Flight (MALDI-TOF), and VITEK-2 analyses were applied to confirm the obtained isolates. Resistance to flucytosine, fluconazole and caspofungin antifungals of the isolates were determined by Etest and VITEK-2. The genetic homologies of Candida spp. isolates were determined by Repetitive Extragenic Palindromic-PCR (RepPCR). In this study 62 (from 53 healthy, 9 mastitic) yeast isolates were obtained and 37 (59.6 %) were identified as non-albicans Candida (NAC) species. Phenotypic tests revealed that out of 62 isolates, 29 (46.7 %), 4 (6.5 %), 3 (4.8 %), 1 (1.6 %) and, 24 (38.7 %) were identified as Candida lusitaniae, Candida catenulate, Candida tropicalis, Candida silvicola and other yeast species, respectively. Only one sample (1.6 %) was identified as Candida albicans by MALDI-TOF however, according to VITEK-2, the agent was not confirmed as C. albicans. According to antifungal susceptibility testing by VITEK-2, one (2.7 %) of the isolates was resistant to fluconazole, one (2.7 %) was resistant to caspofungin, and 4 (10.8 %) were resistant to flucytosine. However, using E test, 10 isolates (27 %) were resistant to flucytosine. Using Rep-PCR, eight genotypic clones were observed. Genotype F (13.8 %) and G (13.8 %; 2 subtypes) were common clones in this study. In conclusion, NAC species were detected in healthy and mastitic cow milk samples. Epidemiological studies need to be conducted to track effectively the main source and to understand the diversity and distribution of the agent. It is necessary to consider the potential risks of yeast contamination in milk for public health. It is essential to focus on adequate sanitation procedures and storage conditions of milk

Preliminary Report on the 2021 Fieldwork at Phoenix

Situé dans la partie sud-ouest de la péninsule de Bozburun (Marmaris), le site an- tique de Phoenix a fait l'objet d'une première campagne de prospection archéologique multidisciplinaire durant le mois de septembre 2021. Les travaux sur le terrain avaient pour objectif de mieux connaître l'espace urbain du site en général, ainsi que certaines structures en particulier, comme le temple d'Apollon transformé en église, l'acropole et les nécropoles parsemées de nombreuses terrasses. Parallèlement à nos recherches purement archéologiques, nous avons pu mettre en œuvre un programme d'éducation sur le patrimoine culturel et écologique pour les enfants vivant dans la région. Nous avons également lancé un programme pour documenter l'architecture rurale de la région et nous avons mené des entretiens d'histoire orale avec les personnes âgées du village de Taşlıca.Located in the southwestern part of the Bozburun Peninsula (Marmaris), the ancient site of Phoenix was the subject of a first multidisciplinary archaeological survey campaign in September 2021. The fieldwork aimed to better understand the town planning of the site in general, as well as certain structures in particular such as the temple of Apollo converted into a church, the acropolis, and the necropoleis dotted with numerous terraces. In addition to purely archaeological research, we also carried out a cultural and ecological heritage edu- cation program for children who live in the region. We also started a program to document the area’s rural architecture and conducted oral history interviews with the elderly people of Taşlıca village