The effects of zoledronic acid treatment on depression and quality of life in women with postmenopausal osteoporosis: A clinical trial study

Background: Osteoporosis affects quality of life (QoL) and may lead to depression in women. he purpose of this study was to evaluate the effects of zoledronic acid (ZA) treatment on depression and QoL in women with postmenopausal osteoporosis (PO). Materials and Methods: A total of 88 newly diagnosed women with PO were included in this study. All patients were treated with once-yearly ZA (5 mg). A QoL questionnaire from the European Foundation for Osteoporosis and Beck Depression Inventory were given to patients at baseline and at 12 months. he results for baseline and post - 12th month were compared, and bone mineral density (BMD) levels were compared. Results: he consumption of once-yearly ZA (5 mg) treatment increases BMD at levels of lumbers 1-4 (P = 0.026), total Hip T score's P value is same as femoral neck (P: 0,033). ZA 5 mg treatment also improved QoL (P = 0.001) and reduced depression (P = 0.001). Conclusion: ZA treatment increases BMD levels and QoL while reducing depression. Once-yearly ZA (5 mg) may be considered for postmenopausal women as a first-line treatment

Caffeic acid phenethyl ester and vitamin E moderates IL-1 beta and IL-6 in bleomycin-induced pulmonary fibrosis in rats

WOS: 000246930700014The aim of this study was to investigate the effects of Caffeic acid phenethyl ester (CAPE), which has been demonstrated to have anti-inflammatory, antiproliferative, anticancerogenic, and antioxidant effects, and vitamin E on IL-1 beta and IL-6 in bleomycin-induced (BLM-induced) pulmonary fibrosis in rats. Thirty-two Sprague-Dawley rats were divided randomly into four groups as untreated control, bleomycin, bleomycin + CAPE, and bleomycin + vitamin E groups. At the end of the treatment, blood IL-1 beta and IL-6 levels were quantified. Bleomycin application to the rats resulted in a significant increase in the cytokine levels as compared to the controls. Administration of CAPE and vitamin E prevented the increase of blood IL-1 beta and IL-6 levels compared to the rats treated with bleomycin alone. Data presented here suggest that CAPE and vitamin E play a protective and moderator role against BLM-induced lung injuries by decreasing the primary inflammatory cytokines, such as IL-1 beta and IL-6. (c) 2006 Elsevier Inc. All rights reserved

Türk milli güreşçilerin ve sedanterlerin serum leptin ve serum lipoprotein seviyeleri ve glukoz homeostazının karşılaştırılması

Amaç: Leptin açlığı bastırarak vücuttaki yağ depolarının miktarını kontrol etmektedir. Güreşte yağ metabolizması, sadece aerobik enerji sistemi için değil, müsabakalardan önce vücut ağırlığının kontrolü ve kilo düşme açısından da önemlidir. Bu çalışmanın amacı, Türk Milli Güreşçilerinin ve sedanterlerin serum leptin ve lipoprotein seviyeleri ve glukoz homeostazını ölçmek ve karşılaştırmaktı. Yöntem ve gereç: Pekin 2008 Olimpiyat Oyunları öncesinde hazırlık kampı yapan 45 Türk Milli Takımı güreşçisi ve 43 üniversite öğrencisi sedanter denek olarak seçildi. Egzersiz sonrası serum leptin, HOMA değerleri, trigliseritler, total kolesterol, LDL-kolesterol, HDL-kolesterol and VLDL-kolesterol, bir gece açlıktan sonra ölçüldü. İki grup arasındaki farklılığın test edilmesinde A Mann-Whitney U testi kullanıldı. Leptin ve diğer parametreler arasında korelasyon katsayıları hesaplandı. Bulgular: Bu çalışmanın sonuçları, iki grubun ortalama leptin ve total kolestrol değerleri arasında fark olmadığını gösterdi. Güreşçiler, sedanterlerden anlamlı şekilde daha yüksek açlık insulin, HDL-kolesterol, trigliserit seviyelerine ve HOMA değerlerine sahipti. Fakat LDL-kolesterol seviyesi daha düşüktü. Sadece leptin ve açlık insülin seviyeleri arasında anlamlı korelasyon vardı (r = 0,310, P = 0,043). Sonuç: Bu çalışma, güreş antrenmanının bir gece açlıktan sonra istirahat leptin seviyesine etki etmediğini ve güreşçilerin artan insulin düzeyi, HDL-kolesterol, trigliserit seviyeleri ve HOMA değerleri ile azalan insulin duyarlılığına sahip olduğunu ortaya koymaktadır.Aim: Leptin is an important controller of the size of fat stores by inhibiting appetite. In wrestling, fat metabolism is important not only for aerobic energy system, but also for weight control and weight loss before competition. The aim of this study was to measure and compare the serum leptin levels, glucose homeostasis, and serum lipoproteins between Turkish national wrestlers and sedentary males. Materials and methods: Forty-five Turkish national wrestlers at the end of Olympic training camp before Beijing 2008 Olympic Games and 43 sedentary students were selected as subjects. Post-exercise levels of serum leptin, HOMA (Homeostasis model assessment) values, triglycerides, total cholesterol, LDL-cholesterol, HDL-cholesterol, and VLDL- cholesterol were measured after overnight fasting. A Mann-Whitney U test was used to test the differences between 2 groups. Pearson Correlation was conducted between leptin and the other parameters. Results: No significant difference was observed among the means of leptin and total cholesterol levels of the 2 groups. Wrestlers had significantly higher fasting insulin, HDL-cholesterol, triglyceride, and HOMA levels, but a lower LDL- cholesterol level compared to the sedentary males. The positive correlation was only found between leptin and fasting insulin levels (r = 0.310, P = 0.043). Conclusion: This study indicated that wrestling training had no effect on resting leptin level after overnight fasting and wrestlers had also decreased insulin sensitivity with higher fasting insulin, HDL-cholesterol, triglyceride, and HOMA levels compared to sedentary males

Marine-Lenhart syndrome with papillary thyroid carcinoma

Yazici, Zihni Acar/0000-0003-1603-6545WOS: 000357264500017PubMed: 26110000Graves' disease with accompanying functioning nodules is known as Marine-Lenhart syndrome. Autonomously functioning thyroid nodules (AFTNs) also within Graves' thyroid tissue are almost always bening in nature. A 45-year-old man developed hyperthyroidism due to the coexistence of Graves' disease and AFTN. Total thyroidectomy was performed. the hyperfunctioning nodule with centrally hypoactive foci detected by technetium-99m thyroid scanning was histologically diagnosed as papillary thyroid carcinoma that was 2.5 cm in diameter. We report the presence of papillary thyroid carcinoma within AFTN in patients with Marine-Lenhart syndrome, which has not been reported so far

Hypothalamic-pituitary-adrenal axis in patients with ankylosing spondylitis

OBJECTIVE: To investigate the hypothalamic-pituitary-adrenal (HPA) axis via the insulin-tolerance test (ITT), standard-dose (250 mu g) ACTH test (SDT) and low-dose (1 mu g) ACTH test (LDT) in patients with ankylosing spondylitis (AS). DESIGN: The study group included 13 male patients with AS who were diagnosed according to the Modified New York criteria, and 8 healthy male subjects and was carried out at the Department of Physical Medicine and Rehabilitation, Erciyes University Medical School. ACTH stimulation tests were carried out by using 1 mu g and 250 mu g i.v. ACTH as a bolus injection, and blood samples were drawn at 0, 30 and 60 min. ITT was performed by using intravenous (i.v.) soluble insulin, and serum glucose and cortisol levels were measured before and after 30, 60, 90 and 120 min. All of the tests were performed consecutively with 3-day intervals, after an overnight fast. RESULTS: There were no significant differences between the patients with AS (mean age 36.9+/-6.7 years) and the healthy subjects (mean age 37.4 +/- 5.7 years) in terms of age. The basal cortisol levels in the AS group measured during LDT, SDT and ITT (556 +/- 204 nmol/l; 524 +/- 169 nmol/l; 418 +/-232 nmol/l, respectively) were comparable to the values of the control group (572 +/- 199 nmol/l; 520 +/- 182 nmol/l; 424 +/- 194 nmol/l, respectively). There were also no significant differences in peak cortisol responses between the two groups using LDT (patients 1025 +/- 339 nmol/l; controls 844 +/- 236 nmol/l), SDT (patients 1082 +/- 243 nmol/l; controls 1120 +/- 131 nmol/l) and ITT (patients 834 +/- 256 nmol/; controls 820 +/- 239 nmol/). CONCLUSION: In contrast with findings in other inflammatory diseases such as rheumatoid arthritis and polymyalgia rheumatica, the present data indicate that there is no apparent abnormality of the HPA axis activity in patients with AS

Evaluation of cardiac influences in patients with type II diabetes mellitus by tissue Doppler imaging

Amaç: Diyabetik kardiyomiyopati, koroner arter hastalığı (KAH) ve hipertansiyondan bağımsız olarak diyabetes mellitus (DM)'a bağlı gelişen primer kardiyak fonksiyon bozukluğu olarak tanımlanır. Doku Doppler görüntüleme (DDG) miyokardiyal hızların ölçülmesiyle sol ventrikülün (LV) sistolik ve diyastolik fonksiyonlarının segmenter olarak değerlendirilmesine izin veren yeni ve üstün bir tekniktir. Çalışmamızda DM'un LV fonksiyonlarına etkisini DDG yöntemiyle incelenmesi amaçlandı. Gereç ve Yöntem: Çalışmaya 60 Tip II Diyabetli hasta (36 kadın, 24 erkek; yaş ort:49.3±8.8 yıl) dahil edildi. Standart M-Mod, mitral inflow, pulmoner venöz akım hızları yanında, DDG yöntemiyle off-line mitral anulus, LV segmental miyokardiyal hızları ve hız zaman değişkenleri ölçüldü. Bulgular: DM grubunda LV sistolik, diyastolik çapları ve hacimleri azalmış, duvar kalınlıkları ve kitlesi artmıştı. Global sistolik fonksiyon göstergeleri normaldi. DM grubunda A velositesi artmış, EDZ ve IRT uzamış, pulmoner ven sistolik dalga hızı azalmıştı. DDG'de S velositeleri her iki grupta benzerdi. DM hastalarında E' velositesi azalmış, A' artmış, IRT' ve EDZ' uzamış olarak saptandı Sonuç: KAH ve hipertansiyonu olmayan DM'lu olgular DDG ile incelendiğinde, diyastolik fonksiyonlarda sol ventrikülün bazı segmentlerinde daha belirgin olmak üzere bozulma gelişmektedir.Aim: Diabetic cardiomyopathy is defined as primary cardiac dysfunction due to diabetes mellitus (DM) independent of coronary artery disease (CAD) and hypertension. Tissue Doppler imaging (TDI) is a recently developed unique technique that allows assessment of regional left ventricular (LV) systolic and diastolic functions by measurements of myocardial velocities. In our study, we aimed to investigate the effect of DM on LV functions by using TDI. Material and Method: Sixty patients with Type II DM (36 female, 24 male, mean age: 49.3±8.8 yrs) were included into the study. As well as standard M-Mode, mitral inflow and pulmonary venous flow velocities, we also measured off-line mitral annulus and LV segmentary myocardial velocities and velocity time intervals by TDI method. Results: LV diastolic and systolic diameters and volumes were found to be decreased and wall thickness and mass increased in diabetic group. Global systolic function parameters were normal. In diabetic group, A velocity was increased, EDT and IRT were prolonged and pulmonary venous systolic velocity decreased. In TDI evaluation, S velocities of both groups were similar. In patients with DM, E' velocities were decreased, A' was increased and IRT' and EDT' were prolonged. Conclusion: When diabetic patients not having CAD or hypertension evaluated by TDI, it was observed that diastolic functions were impaired and this impairment was more prominent in some segments of LV