Umap, inteligencia colectiva extraída de las redes sociales

The Umap project is a practical attempt to obtain collective intelligence from the flow of social networks: links that users share are analyzed, filtered and rated, making it feasible to convert collective intelligence into structured information. For example, information, comments and links that are shared by users belonging to a certain community –e. g., linguistic, social, thematic, organizational- are analyzed in real time to obtain trends at specified intervals (e. g., hourly, daily, weekly...). By means of simplicity search algorithms, the information flow becomes an automated news bulletin with its own value but to which opinions and the relevance that users of social networks give them are added. Umap opens the way for future applications centred in the extraction of information and collective intelligence from communities that share social, political, economical, trading, business, products, brand, technological and other interests through social networks. The first applications of the Umap project developed by CodeSyntax are available at http://www.umap.e

Umap, collective intelligence extracted from social networks

The Umap project is a practical attempt to obtain collective intelligence from the flow of social networks: links that users share are analyzed, filtered and rated, making it feasible to convert collective intelligence into structured information. For example, information, comments and links that are shared by users belonging to a certain community –e. g., linguistic, social, thematic, organizational- are analyzed in real time to obtain trends at specified intervals (e. g., hourly, daily, weekly...). By means of simplicity search algorithms, the information flow becomes an automated news bulletin with its own value but to which opinions and the relevance that users of social networks give them are added. Umap opens the way for future applications centred in the extraction of information and collective intelligence from communities that share social, political, economical, trading, business, products, brand, technological and other interests through social networks. The first applications of the Umap project developed by CodeSyntax are already available at http://www.umap.e

Umap, inteligencia colectiva extraída de las redes sociales

The Umap project is a practical attempt to obtain collective intelligence from the flow of social networks: links that users share are analyzed, filtered and rated, making it feasible to convert collective intelligence into structured information. For example, information, comments and links that are shared by users belonging to a certain community –e. g., linguistic, social, thematic, organizational- are analyzed in real time to obtain trends at specified intervals (e. g., hourly, daily, weekly...). By means of simplicity search algorithms, the information flow becomes an automated news bulletin with its own value but to which opinions and the relevance that users of social networks give them are added. Umap opens the way for future applications centred in the extraction of information and collective intelligence from communities that share social, political, economical, trading, business, products, brand, technological and other interests through social networks. The first applications of the Umap project developed by CodeSyntax are available at http://www.umap.e

Study of Tissue-Specific Reactive Oxygen Species Formation by Cell Membrane Microarrays for the Characterization of Bioactive Compounds

The production of reactive oxygen species (ROS) increases considerably in situations of cellular stress, inducing lipid peroxidation and multiple alterations in proteins and nucleic acids. However, sensitivity to oxidative damage varies between organs and tissues depending on the triggering process. Certain drugs used in the treatment of diverse diseases such as malaria have side effects similar to those produced by oxidative damage, although no specific study has been conducted. For this purpose, cell membrane microarrays were developed and the superoxide production evoked by the mitochondrial activity was assayed in the presence of specific inhibitors: rotenone, antimycin A and azide. Once the protocol was set up on cell membrane isolated from rat brain areas, the effect of six antimalarial drugs (atovaquone, quinidine, doxycycline, mefloquine, artemisinin, and tafenoquine) and two essential oils (Rosmarinus officinalis and Origanum majoricum) were evaluated in multiple human samples. The basal activity was different depending on the type of tissue, the liver, jejunum and adrenal gland being the ones with the highest amount of superoxide. The antimalarial drugs studied showed specific behavior according to the type of human tissue analyzed, with atovaquone and quinidine producing the highest percentage of superoxide formation, and doxycycline the lowest. In conclusion, the analysis of superoxide production evaluated in cell membranes of a collection of human tissues allowed for the characterization of the safety profile of these antimalarial drugs against toxicity mediated by oxidative stressThis work has been partially supported by grant Ministry of Economy and Competitiveness PID2019-106222RB-C31/SRA (State Research Agency, 10.13039/501100011033), the Basque Government Department of Economic Development, Sustainability and Environment (PUE21-03 and Bikaintek program: 48-AF-W2-2019-7 and 007-B2/2020) and University of the Basque Country (price to the best Master Thesis in collaboration with Institutions and Business)

Characterization of the Antitumor Potential of Extracts of Cannabis sativa Strains with High CBD Content in Human Neuroblastoma

Cannabis has been used for decades as a palliative therapy in the treatment of cancer. This is because of its beneficial effects on the pain and nausea that patients can experience as a result of chemo/radiotherapy. Tetrahydrocannabinol and cannabidiol are the main compounds present in Cannabis sativa, and both exert their actions through a receptor-mediated mechanism and through a non-receptor-mediated mechanism, which modulates the formation of reactive oxygen species. These oxidative stress conditions might trigger lipidic changes, which would compromise cell membrane stability and viability. In this sense, numerous pieces of evidence describe a potential antitumor effect of cannabinoid compounds in different types of cancer, although controversial results limit their implementation. In order to further investigate the possible mechanism involved in the antitumoral effects of cannabinoids, three extracts isolated from Cannabis sativa strains with high cannabidiol content were analyzed. Cell mortality, cytochrome c oxidase activity and the lipid composition of SH-SY5Y cells were determined in the absence and presence of specific cannabinoid ligands, with and without antioxidant pre-treatment. The cell mortality induced by the extracts in this study appeared to be related to the inhibition of the cytochrome c oxidase activity and to the THC concentration. This effect on cell viability was similar to that observed with the cannabinoid agonist WIN55,212-2. The effect was partially blocked by the selective CB1 antagonist AM281, and the antioxidant α-tocopherol. Moreover, certain membrane lipids were affected by the extracts, which demonstrated the importance of oxidative stress in the potential antitumoral effects of cannabinoids.This work has been partially supported by a grant from the Ministry of Economy and Competitiveness (DIN2019-010902 and DIN2020-011349) and the Basque Government Department of Economic Development, Sustainability and Environment (Bikaintek program: 005-B2/2021)

Caracterización del saxofón mediante técnicas de análisis acústico

[ES]El principal objetivo del proyecto titulado “caracterización del saxofón mediante técnicas de análisis acústico” es caracterizar el sonido del instrumento usando técnicas basadas en el análisis de Fourier. El saxofón es un instrumento de viento-madera, fabricado de latón, excitado mediante una lengüeta simple. El instrumentista controla algunos elementos del sistema como la presión del aire en la boquilla y la geometría del tubomediante la apertura o cierre de las teclas. Lo interesante de este estudio es que interactúan aspectos de diferentes ámbitos como la acústica, procesamiento de la señal y música. Además, es conveniente conocer cómoes el funcionamiento físico del instrumento para aprender a tocar dicho instrumento. Las actividades realizadas son: montajedel sistema experimental, grabación y análisis tímbrico de varias notas, mediante el cálculo de los parámetros psicoacústicos.[EU]“Saxofoiaren ezaugarritzea analisi akustikoaren teknikak erabilita” deituriko proiektuaren helburu nagusia Fourier-en analisian oinarritutako teknika ezberdinak erabiliz musika-tresnaren soinua ezaugarritzea da. Saxofoia letoiz egindako egurrezko haize musika-tresna mihiduna da. Instrumentistak zenbait erabaki hartu behar ditu honako hauek adibide direlarik: igorritako airearen presioa eta giltzak ireki edo ixtea hodiaren geometria zehazteko. Ikasketa honek alor ezberdinetako alderdiak kontuan hartzen ditu; akustika, seinalearen prozesaketa eta musika. Gainera, onuragarria da musika-tresnaren jokaera fisikoa ezagutzea musika-tresna jotzen ikasteko. Burututako jarduerak dira: sistema esperimentalaren muntaketa, zenbait noten irarketa eta analisi tinbrikoa, parametro psikoakustikoen kalkuluaren bidez.[EN]The main objective of the Project entitled “Characterization of the saxophone using acoustical analysis techniques” is to characterize the sound of the instrument using techniques based on Fourier analysis. The saxophone is a woodwind instrument, made of brass, excited by a simple reed for. The player controls several elements in the system, including the air pressure in the mouthpiece and the bore geometry via keys. One of the reasons that make this project attractive is that it makes coexist and interact aspects from several domains such as acoustics, signal processing and music. Moreover, understanding the physical operation of the instrument is useful for learning to play the instrument. The activities completed are experimental system assembly, sound recording and timbre analysis of several notes, by means of psychoacousticparametercalculation

Screening System of <i>Cannabis sativa</i> Extracts Based on Their Mitochondrial Safety Profile Using Cytochrome c Oxidase Activity as a Biomarker

The development of Cannabis sativa strains with high cannabidiol (CBD) and low tetrahydrocannabinol (THC) content is a growing field of research, both for medical and recreational use. However, the mechanisms behind clinical actions of cannabinoids are still under investigation, although there is growing evidence that mitochondria play an important role in many of them. Numerous studies have described that cannabinoids modulate mitochondrial activity both through activation of mitochondrial cannabinoid receptors and through direct action on other proteins such as mitochondrial complexes involved in cellular respiration. Thus, the aim of this study was to determine the actions of a panel of extracts, isolated from high-CBD varieties of Cannabis sativa, on the activity of the mitochondrial electron transport chain complex IV, cytochrome c oxidase (CCO), in order to select those with a safer profile. After demonstrating that Cannabis sativa strains could be identified by cannabinoids content, concentration–response curves were performed with a collection of extracts from strains with high-CBD and low-THC content using bovine CCO. The CCO rate was clearly modified by specific extracts of Cannabis sativa plants compared to others. Half maximal inhibitory concentrations (IC50) of extracts and the inhibitory effects evoked at 1 × 10−4 g/mL displayed a significant correlation with the THC. Therefore, the screening of extracts based on CCO activity provides a powerful and rapid methodology to identify those plants with higher mitochondrial toxicity or even mito-protective actions