The rediscovery of Palmyra and its dissemination in Philosophical Transactions

This paper examines the first publicly documented western encounter with the ancient city of Palmyra as an archaeological site. This encounter was achieved in the late seventeenth century by a group of British merchants, who reached Palmyra and made drawings and reports of its ruins. The reports were then published in Philosophical Transactions in the mid 1690s. This paper points to the ways in which such accounts came into being, as well as how the city was described and publicly communicated for the first time in Philosophical Transactions. These articles had a great impact throughout the following centuries as a reference for the study of Palmyra. This paper therefore also stresses the pivotal role of Philosophical Transactions for the production and dissemination of Palmyra's archaeological legacy, as well as for the development of early modern archaeology within the early Royal Society

Uniformly bounded representations and completely bounded multipliers of SL(2,R)

We estimate the norms of many matrix coefficients of irreducible uniformly bounded representations of SL(2, R) as completely bounded multipliers of the Fourier algebra. Our results suggest that the known inequality relating the uniformly bounded norm of a representation and the completely bounded norm of its coefficients may not be optimal

Sex-differences in oral anticoagulation therapy in patients hospitalized with atrial fibrillation:a nationwide cohort study

Background Important disparities in the treatment and outcomes of women and men with atrial fibrillation (AF) are well recognized. Whether introduction of direct oral anticoagulants has reduced disparities in treatment is uncertain. Methods and Results All patients who had an incident hospitalization from 2010 to 2019 with nonvalvular AF in Scotland were included in the present cohort study. Community drug dispensing data were used to determine prescribed oral anticoagulation therapy and comorbidity status. Logistic regression modeling was used to evaluate patient factors associated with treatment with vitamin K antagonists and direct oral anticoagulants. A total of 172 989 patients (48% women [82 833 of 172 989]) had an incident hospitalization with nonvalvular AF in Scotland between 2010 and 2019. By 2019, factor Xa inhibitors accounted for 83.6% of all oral anticoagulants prescribed, while treatment with vitamin K antagonists and direct thrombin inhibitors declined to 15.9% and 0.6%, respectively. Women were less likely to be prescribed any oral anticoagulation therapy compared with men (adjusted odds ratio [aOR], 0.68 [95% CI, 0.67–0.70]). This disparity was mainly attributed to vitamin K antagonists (aOR, 0.68 [95% CI, 0.66–0.70]), while there was less disparity in the use of factor Xa inhibitors between women and men (aOR, 0.92 [95% CI, 0.90–0.95]). Conclusions Women with nonvalvular AF were significantly less likely to be prescribed vitamin K antagonists compared with men. Most patients admitted to the hospital in Scotland with incident nonvalvular AF are now treated with factor Xa inhibitors and this is associated with fewer treatment disparities between women and men

How do cardiologists select patients for dual antiplatelet therapy continuation beyond 1 year after a myocardial infarction? Insights from the EYESHOT Post-MI Study

Background: Current guidelines suggest to consider dual antiplatelet therapy (DAPT) continuation for longer than 12 months in selected patients with myocardial infarction (MI). Hypothesis: We sought to assess the criteria used by cardiologists in daily practice to select patients with a history of MI eligible for DAPT continuation beyond 1 year. Methods: We analyzed data from the EYESHOT Post-MI, a prospective, observational, nationwide study aimed to evaluate the management of patients presenting to cardiologists 1 to 3 years from the last MI event. Results: Out of the 1633 post-MI patients enrolled in the study between March and December 2017, 557 (34.1%) were on DAPT at the time of enrolment, and 450 (27.6%) were prescribed DAPT after cardiologist assessment. At multivariate analyses, a percutaneous coronary intervention (PCI) with multiple stents and the presence of peripheral artery disease (PAD) resulted as independent predictors of DAPT continuation, while atrial fibrillation was the only independent predictor of DAPT interruption for patients both at the second and the third year from MI at enrolment and the time of discharge/end of the visit. Conclusions: Risk scores recommended by current guidelines for guiding decisions on DAPT duration are underused and misused in clinical practice. A PCI with multiple stents and a history of PAD resulted as the clinical variables more frequently associated with DAPT continuation beyond 1 year from the index MI

A Landscape of Conflict: Speculators and Books in Early Modern London

This article examines the speculative building world of late seventeenth-century London, a context often associated with the birth of modern real estate culture. It examines existing literature on the subject, and identifies the economic and social conditions that converged in producing new paradigms of speculative construction, as well as the actors and instruments involved in its codification. Rather than through the design and authorial practices usually associated with architects, building was realized based on a constellation of conflicting and largely still unsystematized negotiations between the stakeholders, such as builders, landowners, investors, and lessees. This article discusses these paradigms, particularly in relation to a fundamental and overlooked genre of the operational publications produced to organize and codify professional roles and relationships in the business world. I ultimately argue that in order to make sense of our capitalist building culture, we should reconsider the contentious circumstances that produced it, as well as the knowledge base generated to normalize these circumstances.En este artículo se examina el mundo de la construcción especulativa del Londres de finales del siglo XVII, un contexto que suele relacionarse con el nacimiento de la cultura inmobiliaria moderna. Se revisa también la literatura existente sobre el tema y se identifican las condiciones sociales y económicas que concurrieron para producir los nuevos paradigmas de la construcción especulativa, así como los agentes e instrumentos que ayudaron a consolidar ciertos códigos. La construcción no dependía tanto del diseño o la autoría proyectual que suele asociarse a la figura del arquitecto, sino de una miríada de negociaciones conflictivas y bastante poco sistematizadas entre todos los intervinientes, ya fueran constructores, propietarios del suelo, inversores o arrendatarios. El texto profundiza en estos paradigmas y presta especial atención a un género de publicaciones operativas que, a pesar de no haber recibido la atención que merecen, tuvieron como principal vocación organizar y regular las competencias y las relaciones entre los distintos profesionales de este sector empresarial. Por último, este artículo defiende que, para encontrar el sentido a nuestra cultura edificatoria capitalista, deberíamos reconsiderar las problemáticas circunstancias que la produjeron, así como los principios que sirvieron de base para normalizarlas

A Landscape of Conflict: Speculators and Books in Early Modern London

This article examines the speculative building world of late seventeenth-century London, a context often associated with the birth of modern real estate culture. It examines existing literature on the subject, and identifies the economic and social conditions that converged in producing new paradigms of speculative construction, as well as the actors and instruments involved in its codification. Rather than through the design and authorial practices usually associated with architects, building was realized based on a constellation of conflicting and largely still unsystematized negotiations between the stakeholders, such as builders, landowners, investors, and lessees. This article discusses these paradigms, particularly in relation to a fundamental and overlooked genre of the operational publications produced to organize and codify professional roles and relationships in the business world. I ultimately argue that in order to make sense of our capitalist building culture, we should reconsider the contentious circumstances that produced it, as well as the knowledge base generated to normalize these circumstances.En este artículo se examina el mundo de la construcción especulativa del Londres de finales del siglo XVII, un contexto que suele relacionarse con el nacimiento de la cultura inmobiliaria moderna. Se revisa también la literatura existente sobre el tema y se identifican las condiciones sociales y económicas que concurrieron para producir los nuevos paradigmas de la construcción especulativa, así como los agentes e instrumentos que ayudaron a consolidar ciertos códigos. La construcción no dependía tanto del diseño o la autoría proyectual que suele asociarse a la figura del arquitecto, sino de una miríada de negociaciones conflictivas y bastante poco sistematizadas entre todos los intervinientes, ya fueran constructores, propietarios del suelo, inversores o arrendatarios. El texto profundiza en estos paradigmas y presta especial atención a un género de publicaciones operativas que, a pesar de no haber recibido la atención que merecen, tuvieron como principal vocación organizar y regular las competencias y las relaciones entre los distintos profesionales de este sector empresarial. Por último, este artículo defiende que, para encontrar el sentido a nuestra cultura edificatoria capitalista, deberíamos reconsiderar las problemáticas circunstancias que la produjeron, así como los principios que sirvieron de base para normalizarlas

Ritorno al mondo nuovo

L\u2019analisi del planisfero di Visconte Maggiolo, uno dei primi a rappresentare il nuovo continente americano, e dei cimeli pi\uf9 significativi di carattere geografico e storico-cartografico della Biblioteca comunale di Fano