11,592 research outputs found
Strong inapproximability of the shortest reset word
The \v{C}ern\'y conjecture states that every -state synchronizing
automaton has a reset word of length at most . We study the hardness
of finding short reset words. It is known that the exact version of the
problem, i.e., finding the shortest reset word, is NP-hard and coNP-hard, and
complete for the DP class, and that approximating the length of the shortest
reset word within a factor of is NP-hard [Gerbush and Heeringa,
CIAA'10], even for the binary alphabet [Berlinkov, DLT'13]. We significantly
improve on these results by showing that, for every , it is NP-hard
to approximate the length of the shortest reset word within a factor of
. This is essentially tight since a simple -approximation
algorithm exists.Comment: extended abstract to appear in MFCS 201
Implementation of higher-order absorbing boundary conditions for the Einstein equations
We present an implementation of absorbing boundary conditions for the
Einstein equations based on the recent work of Buchman and Sarbach. In this
paper, we assume that spacetime may be linearized about Minkowski space close
to the outer boundary, which is taken to be a coordinate sphere. We reformulate
the boundary conditions as conditions on the gauge-invariant
Regge-Wheeler-Zerilli scalars. Higher-order radial derivatives are eliminated
by rewriting the boundary conditions as a system of ODEs for a set of auxiliary
variables intrinsic to the boundary. From these we construct boundary data for
a set of well-posed constraint-preserving boundary conditions for the Einstein
equations in a first-order generalized harmonic formulation. This construction
has direct applications to outer boundary conditions in simulations of isolated
systems (e.g., binary black holes) as well as to the problem of
Cauchy-perturbative matching. As a test problem for our numerical
implementation, we consider linearized multipolar gravitational waves in TT
gauge, with angular momentum numbers l=2 (Teukolsky waves), 3 and 4. We
demonstrate that the perfectly absorbing boundary condition B_L of order L=l
yields no spurious reflections to linear order in perturbation theory. This is
in contrast to the lower-order absorbing boundary conditions B_L with L<l,
which include the widely used freezing-Psi_0 boundary condition that imposes
the vanishing of the Newman-Penrose scalar Psi_0.Comment: 25 pages, 9 figures. Minor clarifications. Final version to appear in
Class. Quantum Grav
A system for production of defective interfering particles in the absence of infectious influenza A virus
<div><p>Influenza A virus (IAV) infection poses a serious health threat and novel antiviral strategies are needed. Defective interfering particles (DIPs) can be generated in IAV infected cells due to errors of the viral polymerase and may suppress spread of wild type (wt) virus. The antiviral activity of DIPs is exerted by a DI genomic RNA segment that usually contains a large deletion and suppresses amplification of wt segments, potentially by competing for cellular and viral resources. DI-244 is a naturally occurring prototypic segment 1-derived DI RNA in which most of the PB2 open reading frame has been deleted and which is currently developed for antiviral therapy. At present, coinfection with wt virus is required for production of DI-244 particles which raises concerns regarding biosafety and may complicate interpretation of research results. Here, we show that cocultures of 293T and MDCK cell lines stably expressing codon optimized PB2 allow production of DI-244 particles solely from plasmids and in the absence of helper virus. Moreover, we demonstrate that infectivity of these particles can be quantified using MDCK-PB2 cells. Finally, we report that the DI-244 particles produced in this novel system exert potent antiviral activity against H1N1 and H3N2 IAV but not against the unrelated vesicular stomatitis virus. This is the first report of DIP production in the absence of infectious IAV and may spur efforts to develop DIPs for antiviral therapy.</p></div
New Approximability Results for the Robust k-Median Problem
We consider a robust variant of the classical -median problem, introduced
by Anthony et al. \cite{AnthonyGGN10}. In the \emph{Robust -Median problem},
we are given an -vertex metric space and client sets . The objective is to open a set of
facilities such that the worst case connection cost over all client sets is
minimized; in other words, minimize . Anthony
et al.\ showed an approximation algorithm for any metric and
APX-hardness even in the case of uniform metric. In this paper, we show that
their algorithm is nearly tight by providing
approximation hardness, unless . This hardness result holds even for uniform and line
metrics. To our knowledge, this is one of the rare cases in which a problem on
a line metric is hard to approximate to within logarithmic factor. We
complement the hardness result by an experimental evaluation of different
heuristics that shows that very simple heuristics achieve good approximations
for realistic classes of instances.Comment: 19 page
State-insensitive bichromatic optical trapping
We propose a scheme for state-insensitive trapping of neutral atoms by using
light with two independent wavelengths. In particular, we describe the use of
trapping and control lasers to minimize the variance of the potential
experienced by a trapped Rb atom in ground and excited states. We present
calculated values of wavelength pairs for which the 5s and 5p_{3/2} levels have
the same ac Stark shifts in the presence of two laser fields.Comment: 5 pages, 4 figure
Blackbody radiation shift in a 43Ca+ ion optical frequency standard
Motivated by the prospect of an optical frequency standard based on 43Ca+, we
calculate the blackbody radiation (BBR) shift of the 4s_1/2-3d_5/2 clock
transition, which is a major component of the uncertainty budget. The
calculations are based on the relativistic all-order single-double method where
all single and double excitations of the Dirac-Fock wave function are included
to all orders of perturbation theory. Additional calculations are conducted for
the dominant contributions in order to evaluate some omitted high-order
corrections and estimate the uncertainties of the final results. The BBR shift
obtained for this transition is 0.38(1) Hz. The tensor polarizability of the
3d_5/2 level is also calculated and its uncertainty is evaluated as well. Our
results are compared with other calculations.Comment: 4 page
Accurate determination of electric-dipole matrix elements in K and Rb from Stark shift measurements
Stark shifts of potassium and rubidium D1 lines have been measured with high
precision by Miller et al [1]. In this work, we combine these measurements with
our all-order calculations to determine the values of the electric-dipole
matrix elements for the 4p_j-3d_j' transitions in K and for the 5p_j-4d_j'
transitions in Rb to high precision. The 4p_1/2-3d_3/2 and 5p_1/2-4d_3/2
transitions contribute on the order of 90% to the respective polarizabilities
of the np_1/2 states in K and Rb, and the remaining 10% can be accurately
calculated using the relativistic all-order method. Therefore, the combination
of the experimental data and theoretical calculations allows us to determine
the np-(n-1)d matrix elements and their uncertainties. We compare these values
with our all-order calculations of the np-(n-1)d matrix elements in K and Rb
for a benchmark test of the accuracy of the all-order method for transitions
involving nd states. Such matrix elements are of special interest for many
applications, such as determination of magic wavelengths in alkali-metal atoms
for state-insensitive cooling and trapping and determination of blackbody
radiation shifts in optical frequency standards with ions.Comment: 5 page
Privacy, Trust, and Data Sharing in Web-Based and Mobile Research: Participant Perspectives in a Large Nationwide Sample of Men Who Have Sex With Men in the United States
Background: Modern research is heavily reliant on online and mobile technologies, which is particularly true among historically hard-to-reach populations such as gay, bisexual, and other men who have sex with men (GBMSM). Despite this, very little empirical research has been published on participant perspectives about issues such as privacy, trust, and data sharing.
Objective: The objective of our study was to analyze data from an online sample of 11,032 GBMSM in the United States to examine their trust in and perspectives on privacy and data sharing within online and mobile research.
Methods: Participants were recruited via a social networking site or sexual networking app to complete an anonymous online survey. We conducted a series of repeated measures analyses adjusted for between-person factors to examine within-person differences in the following: (1) trust for guarding personal information across different venues (eg, online research conducted by a university vs. an online search engine); (2) privacy concerns about 12 different types of data for three distinct data activities (ie, collection by app owners, anonymous selling to third parties, and anonymous sharing with researchers); and (3) willingness to share those 12 different types of data with researchers. Due to the large sample size, we primarily reported measures of effect size as evidence of clinical significance.
Results: Online research was rated as most trusted and was more trusted than online and mobile technology companies, such as app owners and search engines, by magnitudes of effect that were moderate-to-large (ηpartial2=0.06-0.11). Responding about 12 different types of data, participants expressed more concerns about data being anonymously sold to third-party partners (mean 7.6, median 10.0) and fewer concerns about data being collected by the app owners (mean 5.8, median 5.0) or shared anonymously with researchers (mean 4.6, median 3.0); differences were small-to-moderate in size (ηpartial2=0.01-0.03). Furthermore, participants were most willing to share their public profile information (eg, age) with researchers but least willing to share device usage information (eg, other apps installed); the comparisons were small-to-moderate in size (ηpartial2=0.03).
Conclusions: Participants reported high levels of trust in online and mobile research, which is noteworthy given recent high-profile cases of corporate and government data security breaches and privacy violations. Researchers and ethical boards should keep up with technological shifts to maintain the ability to guard privacy and confidentiality and maintain trust. There was substantial variability in privacy concerns about and willingness to share different types of data, suggesting the need to gain consent for data sharing on a specific rather than broad basis. Finally, we saw evidence of a privacy paradox, whereby participants expressed privacy concerns about the very types of data-related activities they have likely already permitted through the terms of the apps and sites they use regularly
Stable Frank-Kasper phases of self-assembled, soft matter spheres
Single molecular species can self-assemble into Frank Kasper (FK) phases,
finite approximants of dodecagonal quasicrystals, defying intuitive notions
that thermodynamic ground states are maximally symmetric. FK phases are
speculated to emerge as the minimal-distortional packings of space-filling
spherical domains, but a precise quantitation of this distortion and how it
affects assembly thermodynamics remains ambiguous. We use two complementary
approaches to demonstrate that the principles driving FK lattice formation in
diblock copolymers emerge directly from the strong-stretching theory of
spherical domains, in which minimal inter-block area competes with minimal
stretching of space-filling chains. The relative stability of FK lattices is
studied first using a diblock foam model with unconstrained particle volumes
and shapes, which correctly predicts not only the equilibrium {\sigma} lattice,
but also the unequal volumes of the equilibrium domains. We then provide a
molecular interpretation for these results via self-consistent field theory,
illuminating how molecular stiffness regulates the coupling between
intra-domain chain configurations and the asymmetry of local packing. These
findings shed new light on the role of volume exchange on the formation of
distinct FK phases in copolymers, and suggest a paradigm for formation of FK
phases in soft matter systems in which unequal domain volumes are selected by
the thermodynamic competition between distinct measures of shape asymmetry.Comment: 40 pages, 22 figure
A Hypergraph Dictatorship Test with Perfect Completeness
A hypergraph dictatorship test is first introduced by Samorodnitsky and
Trevisan and serves as a key component in their unique games based \PCP
construction. Such a test has oracle access to a collection of functions and
determines whether all the functions are the same dictatorship, or all their
low degree influences are Their test makes queries and has
amortized query complexity but has an inherent loss of
perfect completeness. In this paper we give an adaptive hypergraph dictatorship
test that achieves both perfect completeness and amortized query complexity
.Comment: Some minor correction
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