Ekstrak Terstandar Secara Kimia Daun Brucea Javanica Merrill

The preparation of Brucea leaves have been done for specific parameters and non specific parameter laboratory worb refers to TheNational Agency of Drug and Food Control Regulation for extract quality control. The result for specific extract parameters were the rendement of extraction is 28%, the values of water- extractive and ethanol-extractive are 11.49% and 9.41%, respectively. The result of determination of the non specific parameters of the extract are; loss on drying is 18.95%, the water content is 15.06%, the total ashes is 16.12%. and the level of ashes not dissolved in acid is 11.14%. The analysis of chemical compound shows that the extract containedflavonoid, tannin, and glycoside. For the quantitative control has been measured the level of totalflavonoid wherethe result is 9.901

Pembuatan Sediaan Oral Nutraceutical dari Ekstrak Gambir

 Catechin is one of bioactive compounds in gambier. Result of preliminary studies showed that catechin is active as an antioxidant and antibacterial, thus it was potential as an oral nutraceutical for prevention of dental plaque. In present study, preparation of the oral nutraceutical in the form of mouthwash was performed by variating content of catechin in the extract as formulation parameter. The contents of catechin in the mouthwash solution are 0.01-0.1% (w/v). The mouthwash products were analyzed for pH, antioxidant and antibacterial activities, also particle size. The results showed that mouthwash with catechin content of 0.01-0.08% (w/v) produced the nanoscale of the particle size of mouthwash.Katekin merupakan salah satu senyawa bioaktif yang terkandung dalam gambir. Hasil studi pendahuluan menunjukkan bahwa katekin aktif sebagai antioksidan dan antibakteri, sehingga berpotensi sebagai oral nutraceutical pencegah plak gigi. Pada studi ini, akan dilakukan pembuatan oral nutraceutical dalam bentuk obat kumur dari ekstrak gambir dengan memvariasikan kandungan senyawa aktif katekin dari  ekstrak gambir sebagai parameter formulasi obat kumur, yaitu 0,01-0,1% (b/v). Obat kumur yang dihasilkan, dianalisa pH, aktivitas antioksidan, antibakteri, dan ukuran partikelnya. Hasil studi ini menunjukkan bahwa obat kumur dengan kandungan senyawa aktif katekin 0,01-0,08% (b/v) menghasilkan obat kumur berukuran nano

Pengaruh Marketing Mix Terhadap Minat Beli di E-Commerce Lazada (Studi Pada Mahasiswa Ekonomi Syariah UIN Sulthan Thaha Saifuddin Jambi)

Pergeseran pada ekonomi global yang tinggi telah membuka pintu untuk peluang bisnis yang luar biasa bagi wirausahawan, mereka yang memiliki keinginan untuk menguasai dunia. Dalam membangun bisnis dengan menjadikan pasar global sebagai area penjualan produk menjadi suatu tantangan bagi para wirausaha yang harus dihadapi. Tantangan tersebut berasal dari sesama produk ataupun berbeda. Saat ini, seiring perkembangan teknologi khususnya internet yang dapat memudahkan transaksi antara penjual dengan pembeli tanpa perlu bertatap muka. Hal ini jadi terobosan dalam menghemat waktu, biaya, keterbatasan jarak, dan juga lebih praktis. Marketing mix selain merupakan dasar dari pelaksanaan suatu strategi pemasaran, juga berguna dalam menciptakan sebuah brand produk sebuah perusahaan. Seluruh elemen bauran pemasaran memiliki kontribusi penting untuk membentuk sebuah persepsi konsumen yang dikenal dengan citra merek. Tujuan penelitian ini Untuk mengetahui Marketing Mix memiliki pengaruh secara parsial terhadap minat beli barang secara online dan untuk mengetahui Marketing Mix memiliki pengaruh secara simultan terhadap minat beli barang secara online. Jenis penelitian yang digunakan dalam penelitian ini adalah penelitian kuantitatif dengan pendekatan deskriptif. Teknik pengambilan sampel dalam penelitian ini yaitu menggunakan metode Random Sampling dengan jumlah sampel 75 orang. Hasil penelitian menunjukkan bahwa secara produk tidak berpengaruh signifikan terhadap minat beli, sedangkan harga, tempat dan promosi berpengaruh signifikan terhadap minat beli secara parsial. Produk, harga, tempat dan promosi berpengaruh signifikan terhadap minat beli secara simultan

SELAGINELLA ACTIVE FRACTIONS INDUCE APOPTOSIS ON T47D BREAST CANCER CELL

Apoptosis  is  an  important  target  on  anticancer  mechanism. The  purpose  of  this  research  is  to  investigate  apoptosis  induction of Selaginella plana Hieron active fractions on T47D cells. Absolute ethanol  was  used  to  extract Selaginella  plana powders.  Ethanolic extract  was  dilluted  by  methanol:water  (4:1)  and  then fractionated  by  hexane  (S_Hex),  methylene  chloride  (S_MTC), ethyl acetate (S_EA), and buthanol (S_BuOH). The proliferation of T47D  cell  line  was  detected  by  SRB  (Sulforhodamine  B) assay which  was  measured  at  a  wavelength  of  515nm.  Flowcytometry analysis  to  determine  apoptosis  was  examined  by  Propidium Iodide  (PI)  and  Annexin  V  assay  using  T47D  breast  cancer  cell line.  The  result  showed  that  the  IC50 value  of  S_Hex,  S_MTC, S_EA,  and  S_BuOH  on  T47D  cells  were  107  µg/mL,  4  µg/mL,  6 µg/mL,  and  17  µg/mL  respectively.  The  active  fractions  (S_MTC and  S_EA)  at  its  IC50 concentration  significantly  (P<0.05) increased  the  total  number  of  early  apoptotic  cells  in  the  T47D cells  3.39%  and  4.1%  respectively  compared  to  that  of  control (1.95%).  Based  on  the  result,  methylene  chloride  and  ethyl acetate  fraction  of Selaginella  plana induced  apoptosis  on  T47D cell.Keywords: apoptosis, breast cancer, Selaginell

Anticancer Activity of Ethanolic Extract of Selaginella Plana Hieron. on T47d Cell Line in Vitro

Selaginella sp belongs to the Selaginellaceae family. It has been used in China and Indonesia as a traditional medicine. It hasseveral medicinal properties including antibacterial, anticardiovascular, and anticancer agent. The aim of the present study was to access the anticancer property of the ethanolic extracts of Selaginella plana Hieron. on T47D breast cancer cell line. The proliferation of T47D cell line was detected by SRB (Sulforhodamine B) assay which was measured at a wavelength of 515 nM. The result showed that the IC50 of the ethanolic extract was determined at 7.03 pg/mL. This significant activity was assumed due to its high total flavonoid content. The totalflavonoid content of the ethanolic extract was 23.04%. Flow cytometry analysis indicated that the extract may undergo the cell death via apoptosis pathway. In conclusion, the ethanolic extract of Selaginella plana Hieron: has considerable activity in inhibiting T47D cell line proliferation

Characterization of Ethanol Extract from Katumpangan Air Herbs (Peperomia pellucida L. Kunth

Peperomia pellucida L. Kunth known as “Katumpangan Air” is a potential medicinal plants used traditionally for uric acid, rheumatic, headache, stomachache, antimicrobial. This study aims to establish  the non-specific  and specific parameters of ethanol extract from Katumpangan air (EKA). EKA was collected from three different growth places: South Tangerang (6.833%), Bogor (7.8%) and Yogyakarta (13.125%). The results show that organoleptic extract characterization from three places were same: thick, blackish green brown, bitter and have a characteristic odor. The average content of water-soluble compounds was within range 7.39-13.29%, ethanol-soluble 15.33-16.68%, flavonoid total 3.807-4.244%. The range of moisture content was 12.25-16.34%, ash total 1.21-2.78%, acid insoluble ash 0.19-1.62%, drying shrinkage 21.62-24.98%, specific gravity 1.0010-1.0034 g/mL for the non-specific parameter. Microbial contamination testing results 0.61x103-1.13x103 coloni/g, the contaminant testing mold/yeast 0.1x102-1.7x102 coloni/g, while lead metal 0.15-0.18 mg/kg, cadmium 0-0.11 mg/kg and arsenic <0.005µg/kg

Scan rate Dependent Factor for Antioxidant Activity of Gold Nanofilms Synthesized via Cyclic Voltammetry Technique

Gold nanoparticles (AuNPs) were found to act as antioxidants owing to their inert, high stability, biocompatibility, and non-cytotoxic. The present investigation involved the synthesis of gold nanoparticles through the electrodeposition technique on a substrate comprising Fluorine-doped Tin Oxide (FTO). By manipulating the scan rate parameter, an effective approach can be employed to facilitate precise management of particle morphology and size. The obtained shape of AuNPs were spherical and irregular. In this study, it was observed that gold nanoparticles elicited potent inhibition, particularly at a scan rate of 150 mV/s, with a markedly high inhibition value of 41.27%. The outcome was further supported by an augmented particle distribution density per unit area, which measured as 149,635,036.5/mm²

SELAGINELLA ACTIVE FRACTIONS INDUCE APOPTOSIS ON T47D BREAST CANCER CELL

Apoptosis is an important target on anticancer mechanism. The purpose of this research is to investigate apoptosis induction of Selaginella plana Hieron active fractions on T47D cells. Absolute ethanol was used to extract Selaginella plana powders. Ethanolic extract was dilluted by methanol :water (4: 1) and then fractionated by hexane (S_Hex), methylene chloride (S_MTC), ethyl acetate (S_EA), and buthanol (S_BuOH). The proliferation of T47D cell line was detected by SRB (Sulforhodamine B) assay which was measured at a wavelength of 515nm. Flowcytometry analysis to determine apoptosis was examined by Propidium Iodide (PI) and Annexin V assay using T47D breast cancer cell line. The result showed that the IC&#8325&#8320value of S_Hex, S_MTC,S_EA, and S_BuOH on T47D cells were 107 µg/mL, 4 µg/mL, 6 µg/mL, and 17 µg/mL respectively. The activ.e fractions (S_MTC and S_EA) at its ICso concentration significantly (

Measuring Data

We identify the task of measuring data to quantitatively characterize the composition of machine learning data and datasets. Similar to an object's height, width, and volume, data measurements quantify different attributes of data along common dimensions that support comparison. Several lines of research have proposed what we refer to as measurements, with differing terminology; we bring some of this work together, particularly in fields of computer vision and language, and build from it to motivate measuring data as a critical component of responsible AI development. Measuring data aids in systematically building and analyzing machine learning (ML) data towards specific goals and gaining better control of what modern ML systems will learn. We conclude with a discussion of the many avenues of future work, the limitations of data measurements, and how to leverage these measurement approaches in research and practice