The Psychedelic State Induced By Ayahuasca Modulates The Activity And Connectivity Of The Default Mode Network

The experiences induced by psychedelics share a wide variety of subjective features, related to the complex changes in perception and cognition induced by this class of drugs. A remarkable increase in introspection is at the core of these altered states of consciousness. Self-oriented mental activity has been consistently linked to the Default Mode Network (DMN), a set of brain regionsmore active during rest than during the execution of a goal-directed task. Here we used fMRI technique to inspect the DMN during the psychedelic state induced by Ayahuasca in ten experienced subjects. Ayahuasca is a potion traditionally used by Amazonian Amerindians composed by a mixture of compounds that increase monoaminergic transmission. In particular, we examined whether Ayahuasca changes the activity and connectivity of the DMN and the connection between the DMN and the task-positive network (TPN). Ayahuasca caused a significant decrease in activity throughmost parts of the DMN, including its most consistent hubs: the Posterior Cingulate Cortex (PCC)/Precuneus and the medial Prefrontal Cortex (mPFC). Functional connectivity within the PCC/Precuneus decreased after Ayahuasca intake. No significant change was observed in the DMN-TPN orthogonality. 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Abundance analysis of APOGEE spectra for 58 metal-poor stars from the bulge spheroid

The central part of the Galaxy hosts a multitude of stellar populations, including the spheroidal bulge stars, stars moved to the bulge through secular evolution of the bar, inner halo, inner thick disc, inner thin disc, as well as debris from past accretion events. We identified a sample of 58 candidate stars belonging to the stellar population of the spheroidal bulge, and analyse their abundances. The present calculations of Mg, Ca, and Si lines are in agreement with the ASPCAP abundances, whereas abundances of C, N, O, and Ce are re-examined. We find normal α-element enhancements in oxygen, similar to magnesium, Si, and Ca abundances, which are typical of other bulge stars surveyed in the optical in Baade’s Window. The enhancement of [O/Fe] in these stars suggests that they do not belong to accreted debris. No spread in N abundances is found, and none of the sample stars is N-rich, indicating that these stars are not second generation stars originated in globular clusters. Ce instead is enhanced in the sample stars, which points to an s-process origin such as due to enrichment from early generations of massive fast rotating stars, the so-called spinstars.RR acknowledges a CNPq master fellowship. TM acknowledges FAPESP postdoctoral fellowship no. 2018/03480-7. HE acknowledges a CAPES PhD fellowship. A.P.-V. and S.O.S. acknowledge the DGAPA-PAPIIT grant IA103122. SOS acknowledges a FAPESP PhD fellowship no. 2018/22044-3. SOS and MV acknowledge the support of the Deutsche Forschungsgemeinschaft (DFG, project number: 428473034). BB acknowledges grants from FAPESP, CNPq, and CAPES – Financial code 001. J.G.F-T gratefully acknowledges the grant support provided by Proyecto Fondecyt Iniciación No. 11220340, and also from ANID Concurso de Fomento a la Vinculación Internacional para Instituciones de Investigación Regionales (Modalidad corta duración) Proyecto No. FOVI210020, and from the ESO – Government of Chile Joint Committee 2021 (ORP 023/2021). D.G. gratefully acknowledges support from the ANID BASAL project ACE210002. D.G. also acknowledges financial support from the Dirección de Investigación y Desarrollo de la Universidad de La Serena through the Programa de Incentivo a la Investigación de Académicos (PIA-DIDULS). The work of V.M.P. is supported by NOIRLab, which is managed by the Association of Universities for Research in Astronomy (AURA) under a cooperative agreement with the National Science Foundation. MZ was funded by ANID FONDECYT Regular 1191505, ANID Millennium Institute of Astrophysics (MAS) under grant ICN12_009, the ANID BASAL Center for Astrophysics and Associated Technologies (CATA) through grants AFB170002, ACE210002 and FB210003. DM gratefully acknowledges support by the ANID BASAL projects ACE210002 and FB210003 and by Fondecyt Project No. 1220724. RR, BB, TM, HE, SOS, are part of the Brazilian Participation Group (BPG) in the Sloan Digital Sky Survey (SDSS), from the Laboratório Interinstitucional de e-Astronomia – LIneA, Brazil. Funding for the Sloan Digital Sky Survey IV has been provided by the Alfred P. Sloan Foundation, the U.S. Department of Energy Office of Science, and the Participating Institutions. SDSS acknowledges support and resources from the Center for High-Performance Computing at the University of Utah. The SDSS web site is www.sdss.org. SDSS is managed by the Astrophysical Research Consortium for the Participating Institutions of the SDSS Collaboration including the Brazilian Participation Group, the Carnegie Institution for Science, Carnegie Mellon University, Center for Astrophysics | Harvard & Smithsonian (CfA), the Chilean Participation Group, the French Participation Group, Instituto de Astrofísica de Canarias, The Johns Hopkins University, Kavli Institute for the Physics and Mathematics of the Universe (IPMU) / University of Tokyo, the Korean Participation Group, Lawrence Berkeley National Laboratory, Leibniz Institut für Astrophysik Potsdam (AIP), Max-Planck-Institut für Astronomie (MPIA Heidelberg), Max-Planck-Institut für Astrophysik (MPA Garching), Max-Planck-Institut für Extraterrestrische Physik (MPE), National Astronomical Observatories of China, New Mexico State University, New York University, University of Notre Dame, Observatório Nacional / MCTI, The Ohio State University, Pennsylvania State University, Shanghai Astronomical Observatory, United Kingdom Participation Group, Universidad Nacional Autónoma de México, University of Arizona, University of Colorado Boulder, University of Oxford, University of Portsmouth, University of Utah, University of Virginia, University of Washington, University of Wisconsin, Vanderbilt University, and Yale University. This work makes use of data from the European Space Agency (ESA) space mission Gaia. The Gaia mission website is https://www.cosmos.esa.int/gaia. The Gaia archive website is https://archives.esac.esa.int/gaia.Peer reviewe