6 research outputs found
ChikDenMaZika Syndrome: the challenge of diagnosing arboviral infections in the midst of concurrent epidemics
- Author
- A Sarmiento-Ospina
- AD Herrera-Martinez
- AJ Auguste
- AJ Rodriguez-Morales
- AJ Rodriguez-Morales
- AJ Rodriguez-Morales
- AJ Rodriguez-Morales
- AJ Rodriguez-Morales
- AJ Rodriguez-Morales
- AJ Rodriguez-Morales
- AJ Rodriguez-Morales
- AJ Rodriguez-Morales
- AJ Rodriguez-Morales
- AJ Rodriguez-Morales
- Alberto E. Paniz-Mondolfi
- Alfonso J. Rodriguez-Morales
- AM Patino-Barbosa
- AM Patino-Barbosa
- C Kreuder Johnson
- CG Raut
- DL Kasper
- EH Andrade
- GA Calvet
- Gabriela Blohm
- H Noel
- J Lednicky
- JA Benitez
- JC Navarro
- JJ Waggoner
- L Arzuza-Ortega
- LI Zambrano
- M Dupont-Rouzeyrol
- M Munoz
- Marilianna Marquez
- P Alfaro-Toloza
- P Barreiro
- PC Gomez
- PM Rifakis
- PM Rifakis
- R McFarlane
- RK Plowright
- S Mattar
- W Villamil-Gomez
- WE Villamil-Gomez
- WE Villamil-Gomez
- WE Villamil-Gomez
- Wilmer E. Villamil-Gomez
- Y Ling
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
- Author
- A Abbate
- A Abhyankar
- A Adams
- A Agafina
- A Akyea-Djamson
- A Alan
- A Alfieri
- A Alfrey
- A Alvarisqueta
- A Amos
- A Anadiotis
- A Anneveldt
- A Antolick
- A Arthur
- A Aslam
- Abaci F
- Abdullakutty J
- Abhaichand R
- Abib E Jr
- Aboufakher R
- Abrantes J
- Abreu M
- Abulencia K
- Acampora D
- Acampora M
- Accini Mendoza Jl
- Aceto L
- Acevedo B
- Acevedo L
- Acheatel R
- Actis Mv
- Adams M
- Adjic Nc
- Affaki Gs
- Agarwal Dk
- Aggarwal Rk
- Agosta Gf
- Aguilar M
- Aguilar M
- Ahire N
- Ahmad I
- Ahmed Sh
- Ahn Y
- Aish B
- Aiub F
- Aiub J
- Ajax K
- Ajioka M
- Akai Y
- Akatova E
- Akrap B
- Al Joundi T
- Al-Khalili F
- Albisu J
- Alcalde Jm
- Alcide P
- Alfonso T
- Allen J
- Alllison Dc
- Almaliky T
- Amerena J
- Andersen K
- Andor M
- Angelova I
- Angiolillo D
- Anita S
- Anker Sd
- Antalik L
- Antonicelli R
- Aparicio Cv
- Apel T
- Apostolovic S
- Ara M
- Aragorn L
- Arango Jl
- Araujo Fonseca M
- Ardissino D
- Arenas Leon Jl
- Arevalo S
- Argiolas G
- Arif I
- Armas E
- Aron G
- Arora S
- Asafu-Adjaye N
- Ashcom T
- Ashford M
- Ashino K
- Asim Oktay Ao
- Assarsson E
- Ata B
- Ather N
- Atieh M
- Aull L
- Avalos V
- Avdonina N
- Awasthi Ak
- Axthelm C
- Ayala M
- Ayasse D
- Ayasse M
- Azizad M
- Azize Gm
- B Becker
- Baar M
- Babu R
- Backer T
- Badea C
- Baden M
- Baehl S
- Baek C
- Baeumer A
- Bagi Es
- Bai A
- Bailey K
- Bailey S
- Bair S
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- Baker C
- Bakhai A
- Bakker H
- Baksi A
- Baldin Mg
- Bali Hk
- Ballantyne C
- Ballmajo M
- Balode A
- Balukova E
- Bang Sa
- Banker D
- Banker K
- Baquero A
- Barbarash Ol
- Barbato E
- Barbosa E
- Barnett S
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- Barreto M
- Barroso A
- Barroso W
- Bartkowiak A
- Bartosh L
- Bartuseviciene S
- Bashir K
- Baszak J
- Bata Ir
- Bayram E
- Beall K
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- Belohlavek J
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- Benjamin S
- Benton J
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- Bitzer V
- Blagdon M
- Blahey M
- Blankenberg S
- Blazsek Z
- Bloch S
- Blom Kb
- Bluemel J
- Blumberg C
- Blumenthal R
- Bocanera M
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- D Dash
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- D Desai
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- Diago M
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- Dong X
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- Dorogova I
- Dos Santos A
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- Doughty A
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- Ellenbroek D
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- Ferreira-Jardim A
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- Flather M
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- Frankenstein L
- Fratczak M
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- Gutmann J
- Guzman I
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- Yao Z
- Yaoqing H
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- Yigit Z
- Yilmaz Mb
- Yim Kh
- Yim S
- Yokoyama M
- Yong H
- Yoshida M
- Yoshimoto E
- Yossen M
- Young A
- Younis L
- Youssef G
- Yuan Z
- Yunoki C
- Yupanqui H
- Z Zhai
- Z Zilahi
- Zadionchenko V
- Zadra R
- Zagozen P
- Zaidman C
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- Zangroniz P
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- Zarifis I
- Zdrenghea D
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- Zena N
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- Zhou H
- Zidova M
- Zielinski M
- Zieve F
- Zineldine A.
- Zirlik A
- Zucchetti C
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
Background: Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. Methods: We conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1β, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The trial compared three doses of canakinumab (50 mg, 150 mg, and 300 mg, administered subcutaneously every 3 months) with placebo. The primary efficacy end point was nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death. RESULTS: At 48 months, the median reduction from baseline in the high-sensitivity C-reactive protein level was 26 percentage points greater in the group that received the 50-mg dose of canakinumab, 37 percentage points greater in the 150-mg group, and 41 percentage points greater in the 300-mg group than in the placebo group. Canakinumab did not reduce lipid levels from baseline. At a median follow-up of 3.7 years, the incidence rate for the primary end point was 4.50 events per 100 person-years in the placebo group, 4.11 events per 100 person-years in the 50-mg group, 3.86 events per 100 person-years in the 150-mg group, and 3.90 events per 100 person-years in the 300-mg group. The hazard ratios as compared with placebo were as follows: in the 50-mg group, 0.93 (95% confidence interval [CI], 0.80 to 1.07; P = 0.30); in the 150-mg group, 0.85 (95% CI, 0.74 to 0.98; P = 0.021); and in the 300-mg group, 0.86 (95% CI, 0.75 to 0.99; P = 0.031). The 150-mg dose, but not the other doses, met the prespecified multiplicity-adjusted threshold for statistical significance for the primary end point and the secondary end point that additionally included hospitalization for unstable angina that led to urgent revascularization (hazard ratio vs. placebo, 0.83; 95% CI, 0.73 to 0.95; P = 0.005). Canakinumab was associated with a higher incidence of fatal infection than was placebo. There was no significant difference in all-cause mortality (hazard ratio for all canakinumab doses vs. placebo, 0.94; 95% CI, 0.83 to 1.06; P = 0.31). Conclusions: Antiinflammatory therapy targeting the interleukin-1β innate immunity pathway with canakinumab at a dose of 150 mg every 3 months led to a significantly lower rate of recurrent cardiovascular events than placebo, independent of lipid-level lowering. (Funded by Novartis; CANTOS ClinicalTrials.gov number, NCT01327846.
Clinical assessment and pathophysiology of Bothrops venom-related acute kidney injury: a scoping review
- Author
- Acosta RA
- Albuquerque PL
- Albuquerque PL
- Albuquerque PLMM
- Alice Maria Costa Martins
- Alves EC
- Amaral CFS
- AragĂłn F
- Araujo HP
- Aye KP
- Azevedo-Marques MM
- Barbosa PSF
- Bennett MR
- Boer PA
- Bucaretchi F
- Bucaretchi F
- Bucaretchi F
- Burdmann EA
- Cardoso KC
- Carrasco PA
- Chippaux JP
- Chisari A
- Chugh KS
- Collares-Buzato CB
- Cruz LS
- Cupo PAMM
- da Silva CG
- da Silva OA
- Danis R
- Dantas RT
- David L
- de Albuquerque Modesto JC
- de Castro I
- de Morais IC
- De Sousa FC
- Edelstein CL
- Elizabeth De Francesco Daher
- Estevao-Costa MI
- Evangelista IL
- Fernandes CM
- Franca FOS
- Gdayllon Cavalcante Meneses
- Gene JA
- Geraldo Bezerra da Silva JĂşnior
- Gn YM
- Golay V
- Gong R
- Guerreiro JR
- Gundappa RK
- Gutierrez JM
- Gutierrez JM
- Havt A
- Hoste EAJ
- Hrovat A
- Jha V
- Jiménez-Porras JM
- Jiménez-Porras JM
- Jorge MT
- Jorge RJ
- José Hicaro Hellano Gonçalves Lima Paiva
- Junqueira-de-Azevedo IL
- Kouyoumdjian JAPC
- Laines J
- Lima LCA
- Linardi A
- Machado Braga MD
- Maduwage K
- Malaque CMS
- Malaque CMS
- Mandelbaum FR
- Marinho AD
- Martins AM
- Mello SM
- Melo PA
- Michael G
- Milani JĂşnior R
- Min JK
- Mohamed F
- Moreira V
- Moreno E
- Moreno JA
- Moura-da-Silva AM
- Moura-da-Silva AM
- Nakamura T
- Nicholas Buckley
- Nishioka SA
- Noutsos T
- Otero R
- Otero-Patino R
- Pacheco UP
- Pinho FM
- Pinho FM
- Pinho FMO
- Polianna Lemos Moura Moreira Albuquerque
- Polizelli JAKC
- Prakash J
- Prezoto BC
- Priyamvada PS
- Priyamvada PS
- Queiroz LP
- Restrepo-Angulo I
- Rezende NA
- Ribeiro LA
- Ribeiro LA
- RNL . Pinto
- Rocha ML
- Rossier BC
- Sant’Ana Malaque CM
- Schattner M
- Schenberg S
- Serra H
- Sgrignolli LR
- Sitprija V
- Sitprija V
- Sitprija V
- Sitprija V
- Slagboom J
- Sousa LF
- Tianyi FL
- Tochie JN
- Torrez PP
- Velez SM
- Vencio D
- Waiddyanatha S
- Wanderley CW
- Yu Gui RL
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- 01/01/2020
- Field of study
Shaping Ability of ProTaper Next, WaveOne, and Reciproc in Simulated Root Canals
- Author
- Berutti E Chiandussi G, Paolino DS, Scotti N, Cantatore G, Castellucci A, Pasqualini D.
- Burklein S Hinschitza K, Dammaschke T, Schafer E.
- Capar ID Ertas H, Ok E, Arslan H, Ertas ET.
- De-Deus G Moreira EJ, Lopes HP, Elias CN.
- Elnaghy AM.
- Fornari VJ Silva-Sousa YT, Vanni JR, Pecora JD, Versiani MA, Sousa-Neto MD.
- Foschi F Nucci C, Montebugnoli L, Marchionni S, Breschi L, Malagnino VA, Prati C.
- Glossen CR Haller RH, Dove SB, del Rio CE.
- Kim HC Kwak SW, Cheung GS, Ko DH, Chung SM, Lee W.
- Lim KC Webber J.
- Maia Filho EM Rizzi Cde C, Coelho MB, Santos SF, Costa LM, Carvalho CN, de Jesus Tavarez RR, Soares JA.
- Montalvao D Alcada FS, Braz Fernandes FM, de Vilaverde-Correia S.
- Paque F Ganahl D, Peters OA.
- Pereira ES Gomes RO, Leroy AM, Singh R, Peters OA, Bahia MG, Buono VT.
- Pereira ES Peixoto IF, Viana AC, Oliveira, II, Gonzalez BM, Buono VT, Bahia MG.
- Ruddle CJ Machtou P, West JD.
- Saber SE Nagy MM, Schafer E.
- Scelza P Harry D, Silva LE, Barbosa IB, Scelza MZ.
- Schneider SW.
- Varela-Patino P Ibanez-Parraga A, Rivas-Mundina B, Cantatore G, Otero XL, Martin-Biedma B.
- Wu H Peng C, Bai Y, Hu X, Wang L, Li C.
- Wu MK Fan B, Wesselink PR.
- Yared G.
- You SY Bae KS, Baek SH, Kum KY, Shon WJ, Lee W.
- Zhang L Luo HX, Zhou XD, Tan H, Huang DM.
- Publication venue
- 'Jaypee Brothers Medical Publishing'
- Publication date
- Field of study
Zika virus outbreak: a review of neurological complications, diagnosis, and treatment options
- Author
- A Bayer
- A Davidson
- A Gulland
- A Rowland
- A Sharma
- AK Hastings
- AM Nicolini
- AM Patino-Barbosa
- AQ Araujo
- AS Oliveira Melo
- B Atkinson
- B Cao
- BD Foy
- BS Pascoalino
- C Li
- C Zanluca
- CF Ayres
- CG Victora
- D Musso
- D Musso
- D Sirohi
- DK Graham
- DL Heymann
- DT Deckard
- E D'Ortenzio
- E Kim
- EB Hayes
- EE Petersen
- FR Cugola
- G Calvet
- G Calvet
- G Duarte
- G Grard
- G Sapparapu
- G Savidis
- GW Dick
- H Li
- H Tang
- HM Lazear
- HM Lazear
- HN Nguyen
- IB Rabe
- IJ Motta
- J Abbasi
- J Dang
- J Govero
- J Kouznetsova
- J Mlakar
- J Song
- JC Saiz
- JE Ledgerwood
- JF Chan
- JJ Miner
- JJ Miner
- JJ Waggoner
- JM Furtado
- JM Mansuy
- JM Skredenske
- JP Boorman
- K Muthumani
- K Pardee
- K Stettler
- K Zhou
- KM Bullard-Feibelman
- KM Quicke
- KY Wu
- L Adams
- L Eyer
- L Meertens
- L Priyamvada
- L Schuler-Faccini
- L Wang
- L Zammarchi
- LJ Yockey
- LM Johansen
- LR Petersen
- M Dupont-Rouzeyrol
- M McCarthy
- M McCarthy
- M Xu
- MF Wells
- MR Duffy
- MR Wise de Valdez
- MT Aliota
- NJ Barrows
- NR Faria
- NW Hanners
- O Faye
- O Faye
- O Faye
- P Abbink
- P Brasil
- P Brasil
- PJ Imperato
- Q Liang
- R Barrera
- R Hamel
- RA Larocca
- RS Adcock
- RS Lanciotti
- S He
- S Liu
- S Mecharles
- SA Ritchie
- SC Weaver
- SD Dowall
- SI Sardi
- SL Hills
- SL Rossi
- SM Thomas
- SN Slavov
- T Bauer
- T Tabata
- T. Shantha Raju
- TJ Nowakowski
- V Koppolu
- Veerendra Koppolu
- VM Cao-Lormeau
- VM Corman
- W Dejnirattisai
- W Sun
- X Qian
- XA Zhang
- Z-Y Wang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study