Contested heritage: an analysis of the physical transformation of Derry/Londonderry’s siege monument

Transformations of Derry/Londonderry’s medieval city walls during the twentieth century have shaped an urbanism of segregated settlements within a city of religious confrontation. The heritage of military blockades, peace lines and watchtowers imposed upon the city’s Walls has influenced the disintegration of public space and created areas of no man’s land around the peripheries of the monument. The aim of this paper is to examine physical transformation and trace the consequences of urban planning regarding the historic city Walls. This change includes the shifting of residential settlements in the Bogside/Fountain areas and the movement of Protestant settlements towards the Waterside of Derry/Londonderry. The history and heritage of the Walls are analysed by focusing on four periods: 1600, when the first medieval walls were constructed; the housing crisis of 1948; the 1968 urban area plan and the beginning of the ‘Troubles’; and the present day. This analysis offers an understanding of the spatial relationships between enclaves and the monument over key moments of conflict and political change. The paper reveals that the manifestations of the Walls have aided in the further division of religiously segregated communities in Derry/Londonderry

Virtual platforms for heritage preservation in the Middle East: the case of medieval Cairo

Much of the effort in VH is directed towards accurate representation of historic structures, objects or artefacts. There is little attention is paid, however, to the human aspects of city life, the intangible heritage to which people can actually relate. Digital models of historic buildings and spaces only give a sense of precision. Yet, rituals, human attitude and cultural traditions remained a gap in current research and advanced technology in heritage visualization. Virtual Heritage Environments (VHE) suffer from the lack of ‘thematic interactivity’ due to the limited cultural content and engaging modules largely used in photorealistic video gaming systems. In order to approach virtual fidelity and accurate reproduction of historic environments, this paper reports on a research process to investigate and incorporate a Cultural-feed into digital platforms of Virtual Heritage. In doing so, the paper focuses on the Middle East in general and Medieval Cairo in particular. It discusses conceptual and practical framework for the development of virtual heritage platforms as a research, educational and engagement tool that brings historic spaces and buildings back to the recognition of the public eye of the ordinary user. It analyses current practices and projects of the virtual heritage technologies and reports on field work that took place in Islamic Cairo with Five Start-Up entrepreneurs

Screening for hen’s egg and chicken meat specific IgE antibodies in Saudi patients with allergic disorders

Background: Allergy to hen’s egg and meat contributes significantly to the manifestations of food allergy all over the world.Objectives: This study was performed to assess the presence of hen’s egg and meat specific IgE antibodies among patients investigated for various allergic disorders.Methods. This is a retrospective study performed at King Khalid University Hosptial, Riyadh. Data from 421 patients with allergic disorders screened for food specific IgE antibodies between January 2009 and March 2011 were analyzed. Sixty (14.25%) patients including 42 males and 18 females with the mean age (sd) of 7.5 (7.4) years were found to have specific IgE antibodies against hen’s egg and chicken meat. There were 56 (93.3%) children and 4 (6.7%) adult patients. Specific IgE antibodies were measured by radioallergosorbent test (RAST) using Pharmacia ImmunoCAP 250 analyzer.Results: Atopic dermatitis was the most common (55%) clinical condition. Out of the total 60 patients harboring hen’s egg and chicken meat specific IgE antibodies high levels of egg white, yolk and chicken meat specific IgEs were detected in 58 (96.6%), 37 (61.6%) and 6 (10%) patients respectively. Both the egg white and yolk antibodies coexisted in 35 (58.3%) patients.Conclusion: Sensitization against hen’s egg was higher compared to the chicken meat. Egg white sensitization higher than the egg yolk particularly in Saudi children with food related allergic disorders.Key words: Allergy, atopic dermatitis, chicken meat, hen’s egg, IgE antibodie

Cytokine gene polymorphisms and serum cytokine levels in patients with idiopathic pulmonary fibrosis

BACKGROUND: Studies have demonstrated associations between cytokine gene polymorphisms and the risk of idiopathic pulmonary fibrosis (IPF). We therefore examined polymorphisms in the genes encoding interleukin (IL)-6, IL-10, interferon gamma (IFN-γ), tumor necrosis factor alpha (TNF-α), and transforming growth factor-beta 1 (TGF-β(1)), and compared the serum levels of these cytokines in IPF patients and healthy controls. Furthermore, we examined the association of the studied genotypes and serum cytokine levels with physiological parameters and the extent of parenchymal involvement determined by high-resolution computed tomography (HRCT). METHODS: Sixty patients with IPF and 150 healthy controls were included. Cytokine genotyping was performed using the polymerase chain reaction sequence specific primer (PCR-SSP) method. In a subset of patients and controls, serum cytokine levels were determined by enzyme-linked immunosorbent assay. RESULTS: There was no difference between IPF patients and controls in the genotype and allele distributions of polymorphisms in TNF-α, IFN-γ, IL-6, IL-10, and TGF-β(1) (all p > 0.05). The TNF-α (−308) GG, IL-6 (−174) GG and CG, and IL-10 (−1082, -819, -592) ACC ATA genotypes were significantly associated with HRCT scores (all p < 0.05). IL-10 (−1082, -819, -592) ACC haplotype was associated with the diffusion capacity of the lung for carbon monoxide, and ATA haplotype was associated with the partial pressure of oxygen (PaO(2)) (all p < 0.05). The TGF-β(1) (codons 10 and 25) TC GG, TC GC, CC GG and CC GC genotypes were significantly associated with the PaO(2) and HRCT scores (p < 0.05). The TGF-β(1) (codons 10 and 25) CC GG genotype (5 patients) was significantly associated with higher PaO(2) value and less parenchymal involvement (i.e., a lower total extent score) compared to the other TGF-β(1) genotypes (81.5 ± 11.8 mm Hg vs. 67.4 ± 11.1 mm Hg, p = 0.009 and 5.60 ± 1.3 vs. 8.51 ± 2.9, p = 0.037, respectively). Significant differences were noted between patients (n = 38) and controls (n = 36) in the serum levels of IL-6 and IL-10 (both, p < 0.0001), but not in the levels of TNF-α and TGF-β(1) (both, p > 0.05). CONCLUSION: The studied genotypes and alleles do not predispose to the development of IPF but appear to play an important role in disease severity. Our results suggest that the TGF-β(1) (codons 10 and 25) CC GG genotype could be a useful genetic marker for identifying a subset of IPF patients with a favorable prognosis; however, validation in a larger sample is required

A Bio-Inspired Heuristic Algorithm for Solving Optimal Power Flow Problem in Hybrid Power System

In recent studies, emphasis has been placed on optimal power flow (OPF) problems in traditional thermal, wind, and solar energy sources-based hybrid power systems. Various metaheuristic algorithms have been proposed to find optimal solutions to the OPF problems in the hybrid power system. The OPF, due to the quadratic nature of its primary objective function, is a nonlinear, nonconvex, and quadratic optimization problem. In this study, we have proposed a bio-inspired bird swarm algorithm (BSA) to find an optimal solution to the OPF problem in the hybrid power system because it performs well in the case of optimizing the well-known Rastrigin quadratic benchmark function. In this study, uncertainty of utility load demand and stochastic electricity output from renewable energy resources (RESs) including wind and solar are incorporated into the hybrid power system for achieving accuracy in operations and planning of the system. We have used a modified IEEE-30 bus test system to verify and measure the performance of BSA and a comparison is made with well-known evolutionary metaheuristic algorithms. The proposed BSA consistently achieves more accurate and stable results than other metaheuristic algorithms. Simulation-based optimization results have shown the superiority of BSA approach to solve the OPF problems by satisfying all constraints and minimum power generation cost 863.121 $\$$ /h is achieved in case study 1. Simulation-based experiment results have indicated that by imposing the carbon tax ( $ton/h$ ) the power generation from RESs was increased. In case study 2, the proposed BSA approach has also outperformed and minimum electricity cost 890.728 $\$$ /h is achieved as compared to other algorithms

A Cost-Effective Optimization for Scheduling of Household Appliances and Energy Resources

In literature, proposed approaches mostly focused on household appliances scheduling for reducing consumers' electricity bills, peak-to-average ratio, electricity usage in peak load hours, and enhancing user comfort level. The scheduling of smart home deployed energy resources recently became a critical issue on demand side due to a higher share of renewable energy sources. In this paper, a new hybrid genetic-based harmony search (HGHS) approach has been proposed for modeling the home energy management system, which contributes to minimizing consumers' electricity bills and electricity usage during peak load hours by scheduling both household appliances and smart home deployed energy resources. We have comparatively evaluated the optimization results obtained from the proposed HGHS and other approaches. The experimental results confirmed the superiority of HGHS over genetic algorithm (GA) and harmony search algorithm (HSA). The proposed HGHS scheduling approach outperformed more efficiently than HSA and GA. The electricity usage cost for completing one-day operation of household appliances was limited to 1305.7 cents, 953.65 cents, and 569.44 cents in the proposed scheduling approach for case I, case II, and case III, respectively and was observed as lower than other approaches. The electricity consumption cost was reduced upto 23.125%, 43.87% and 66.44% in case I, case II, and case III, respectively using proposed scheduling approach as compared to an unscheduled load scenario. Moreover, the electrical peak load was limited to 3.07 kW, 2.9478 kW, and 1.9 kW during the proposed HGHS scheduling approach and was reported as lower than other approaches

Acetyl-L-carnitine and/or liposomal co-enzyme Q10 prevent propionic acid-induced neurotoxicity by modulating oxidative tissue injury, inflammation, and ALDH1A1-RA-RARα signaling in rats

Propionic acid (PPA) is a short-chain fatty acid produced endogenously by gut microbiota and found in foodstuffs and pharmaceutical products as an additive. Exposure to PPA has been associated with the development of autism spectrum disorder (ASD). The purpose of this study was to investigate the protective effect of acetyl‐L‐carnitine (ALCAR) and liposomal Co-enzyme Q10 (CoQ10) against cerebral and cerebellar oxidative injury, inflammation, and cell death, and alterations in ALDH1A1-RA-RARα signaling in an autism-like rat model induced by PPA. The rats were treated with PPA and concurrently received ALCAR and/or CoQ10 for 5 days. The animals were sacrificed, and the cerebral cortex and cerebellum were collected for analysis. PPA caused histopathological alterations along with increased malondialdehyde (MDA), NF-κB p65, TNF-α, and IL-6 in the cerebrum and cerebellum of rats. Reduced glutathione (GSH) and antioxidant enzymes were declined in the brain of rats that received PPA. Concurrent treatment with ALCAR and/or CoQ10 prevented tissue injury, decreased MDA, NF-κB p65, and pro-inflammatory cytokines, and enhanced cellular antioxidants in PPA-administered rats. ALCAR and/or CoQ10 upregulated Bcl-2 and decreased Bax and caspase-3 in the brain of rats. In addition, ALCAR and/or CoQ10 upregulated cerebral and cerebellar ALDH1A1 and RARα in PPA-treated rats. The combination of ALCAR and CoQ10 showed more potent effects when compared with the individual treatments. In conclusion, ALCAR and/or CoQ10 prevented tissue injury, ameliorated oxidative stress, inflammatory response, and apoptosis, and upregulated ALDH1A1-RA-RARα signaling in the brain of autistic rats

Garlic and onion sensitization among Saudi patients screened for food allergy: A hospital based study

BACKGROUND: Detection of specific IgE antibodies against food materials indicates allergic sensitization. Some very widely consumed foods materials such as garlic and onion have rarely been investigated for their allergenic potential. OBJECTIVES: To assess the presence of garlic and onion specific IgE antibodies in patients investigated for food allergy. METHODS: Radioallergosorbent test (RAST) results of 108 patients with clinical suspicion of food allergy who were specifically screened for garlic and onion specific IgE antibodies along with other food allergens were analyzed retrospectively at King Khalid University Hosptial between January 2008 and April 2009. This group of patients included 73 males and 35 females with mean age 27+13.2 years. Estimation of garlic and onion specific IgE antibodies was performed by radioallergosorbent test (RAST) using Pharmacia ImmunoCAP 250 analyzer. RESULTS: Out of the 108 patients 15 (13.8%) had garlic and onion specific IgE antibodies in their sera. Garlic specific IgE antibodies with the RAST scores between one to four were present in 14 and onion specific IgE were detected in 13 patients. For garlic specific IgEs majority of patients (08) had RAST score of one (0.35–0.69 kU/L) and for onion specific IgE antibodies seven patients had RAST score of two (0.70–3.49 kU/L). Among these patients 12 (80%) were found to have coexisting specific IgE antibodies against garlic and onion. CONCLUSION: The presence of garlic and onion specific IgE antibodies in a sizeable number of patients indicate sensitization and allergenic potential of these food materials

Garlic and onion sensitization among Saudi patients screened for food allergy: a hospital based study

Background: Detection of specific IgE antibodies against food materials indicates allergic sensitization. Some very widely consumed foods materials such as garlic and onion have rarely been investigated for their allergenic potential. Objectives: To assess the presence of garlic and onion specific IgE antibodies in patients investigated for food allergy. Methods: Radioallergosorbent test (RAST) results of 108 patients with clinical suspicion of food allergy who were specifically screened for garlic and onion specific IgE antibodies along with other food allergens were analyzed retrospectively at King Khalid University Hosptial between January 2008 and April 2009. This group of patients included 73 males and 35 females with mean age 27+13.2 years. Estimation of garlic and onion specific IgE antibodies was performed by radioallergosorbent test (RAST) using Pharmacia ImmunoCAP 250 analyzer. Results: Out of the 108 patients 15 (13.8%) had garlic and onion specific IgE antibodies in their sera. Garlic specific IgE antibodies with the RAST scores between one to four were present in 14 and onion specific IgE were detected in 13 patients. For garlic specific IgEs majority of patients (08) had RAST score of one (0.35-0.69 kU/L) and for onion specific IgE antibodies seven patients had RAST score of two (0.70-3.49 kU/L). Among these patients 12 (80%) were found to have coexisting specific IgE antibodies against garlic and onion. Conclusion: The presence of garlic and onion specific IgE antibodies in a sizeable number of patients indicate sensitization and allergenic potential of these food materials