Preparation, Antimicrobial Evaluation and Molecular docking of New 2,3-Substituted [1,3] Benzooxazin-4-one derivatives

New 2, 3-substituted benzooxazin-4-one derivatives were prepared by means of a altered step by step proceedings in which Schiff bases were substituted with salicylic acid for a ring forming reaction. The compositions of the synthesized compounds were certain via methods spectrometry as elemental analysis, FT-IR, 13C-NMR & 1H-NMR spectral analysis. The bio-activities for the prepared compounds in-vitro as antibacterial and antifungal were estimated as opposed to two races of gram-positive & two races of gram-negative bacteria as parallel to Cefotaxime sodium as regular drug and assessed versus two types of fungi. The prepared compounds were got to have antimicrobial activities spreading from middling to perfect against of the bacteria strains with good percentage mycelial growth inhibition activity against fungi. Molecular docking displays the critical part while effect of variety of substituents on biological activity while mark the disadvantageous constitutional parameters in drawing medication: A different substitution does ensure additional efficiency in bioactivity

Global survey of the roles, satisfaction, and barriers of home healthcare nurses on the provision of palliative care

Background: the World Health Assembly urges members to build palliative care (PC) capacity as an ethical imperative. Nurses provide PC services in a variety of settings, including the home and may be the only health care professional able to access some disparate populations. Identifying current nursing services, resources, and satisfaction and barriers to nursing practice are essential to build global PC capacity. Objective: to globally examine home health care nurses' practice, satisfaction, and barriers, regarding existing palliative home care provision. Design: needs assessment survey. Setting/Subjects: five hundred thirty-two home health care nurses in 29 countries. Measurements: a needs assessment, developed through literature review and cognitive interviewing. Results: nurses from developing countries performed more duties compared with those from high-income countries, suggesting a lack of resources in developing countries. Significant barriers to providing home care exist: personnel shortages, lack of funding and policies, poor access to end-of-life or hospice services, and decreased community awareness of services provided. Respondents identified lack of time, funding, and coverages as primary educational barriers. In-person local meetings and online courses were suggested as strategies to promote learning. Conclusions: it is imperative that home health care nurses have adequate resources to build PC capacity globally, which is so desperately needed. Nurses must be up to date on current evidence and practice within an evidence-based PC framework. Health care policy to increase necessary resources and the development of a multifaceted intervention to facilitate education about PC is indicated to build global capacity

Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries

Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P < 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely

Survey in Image and Audio Steganography by using the Deep Learning Methods

Steganography is the practise of secretly encoding information into another medium (called a cover media) such that its existence cannot be identified. Steganography is the method that is utilised to successfully do this task. Through the use of digital image steganography, one is able to achieve the capacity of secure communication, which is vital in the bulk of the applications that are now being created. The use of steganography is applicable in a wide variety of advantageous settings. Its ascent to the forefront of current security systems may be attributed to a confluence of factors, including a phenomenal rise in processing power and a heightened awareness among individuals of the need of safeguarding their personal information. When it comes to the creation of a steganographic method, the most significant challenge that must be surmounted is finding the optimal balance between quality and quantity. The method is distinguished from linked systems like encryption and watermarking by its ability to embed information, as well as by the fact that it cannot be seen by the human eye. This article presents a thorough examination and analysis of some contemporary steganographic methods that are regarded as state-of-the-art approaches. In addition, we have included an in-depth discussion of the most important steganographic technologies now available. Recent steganographic techniques that are based on deep learning have been enhanced, which has enabled the resolution of issues that were previously presen

Effect of Interlukin-36 gamma and Tumor Necrosis Factor alpha on Patients with Polycystic Ovary Syndrome on Governorate Messan in Iraqifemale

Background:Polycystic ovary syndrome PCOS is a heterogeneous disorder. PCOS affects 6–10% of women during their reproductive life.Its complete phenotype is manifested by ovulatory dysfunction, hyperandrogenism and polycystic ovaries. Objective: The aim of this study is to evaluate a new recent member of the IL-1 super family of cytokinesinterleukin-36(IL-36) levels in serum that has a crucial roleindiagnosis diseasesand in order to evaluate its utility as a clinical biochemical parameter inPolycystic ovary syndrome. Methods: The present study was conducted on 100 subjects which divided in to 4 groups. First group includes 25healthy individuals as control group . Second group includes 25 female with PCOS aspatient group newly diagnosis .Third group includes 25 patients with PCOS after 12 months from diagnosis. Fourth group also 25 patients after 24 months and more.  All subjects attendingfrom teaching AL-Sadder hospital and AL-Zahrawi hospital in  Governorate of  Messan in Iraq. Parametersmeasured in the sera of patient and healthy groups were interleukin-36 (IL-36), tumor necrosis factor alpha and ceruloplasmin concentration. Results: A recent member of super family cytokines Interterleukin-36(IL-36) was determined in serum of polycystic ovary syndrome. Higher significant elevation was found when compared with healthy control. Conclusion: From this study a conclusion was drawn, that evaluation of concentration of a new superfamilycytokines (IL-36) could be considered as clinical biochemical parameter in polycystic ovary syndrome  in Iraqifemale patients in Governorate of Missan. Also this study may demonstrated a relation between increased IL-36levels and increased TNF-? and ceruloplasmin levels. Keywords: polycystic ovary syndrom, interleukin-36 (IL-36), cytokines, TNF-?,Ceruloplasmi

Using He-Ne laser irradiation for enhancing cartilage Autografts

thirty adult NewZealand rabbits used in this study, they were divided in to two groups (control and treaded with Helium — Neon laser). A square skin flap done on the medial aspect of the auricle of both sides, a square piece of cartilage incised, pealed out from each auricle and fixed in the site of the other, then the flaps sutured .The site of the operation in the rabbits of the treated group were irradiated using a Helium —Neon laser with (5mw) power for (10 days) began after the operation directly, (3 rabbits) from each group used for collection of specimens for histopathological examination at the weeks (1,2,3,4, & 6) weeks post the operation .The results revealed Early invasion of the matrix with elastic fibers which continue to the surrounding perichondrium, mature lacunae and complete healing occurred later at the 6th week in the treated group. Conclusion: Helium- Neon laser raised the mitotic activity of the cartilage cells, activated the reproduction processes in addition to the intra and extra regenerative reparation

A comparative study on the role of bone morphogenetic protein in ovarian development and function in mice and ewes

Fertility in females is totally dependent on the growth and proliferation of primordial follicles to mature into Graafian follicles. Several factors are involved in the regulation of ovarian follicle development from the follicle recruitment to ovulation. Among these regulatory factors is the bone morphogenetic protein family (BMP). ... We studied the effect of four different concentrations of equine chorionic gonadotropin (eCG) on follicle recruitment in female Swiss mice, which demonstrated that there were significant differences in regard to the number of primordial, developing and atretic follicles with different doses of eCG administered

Genotyping of Vibrio cholera for Virulence Factors in Diwaniyah City - Iraq

Cholera is one of the most important epidemic diseases globally. It is causing of morbidity and mortality in the world. Severe watery diarrhea causes a composite process involving several component that help them reach the lining of the small intestine, form colonies and generate bacterial toxins. This survey was carried out to discover the genetic patterns of clinical isolates according to the presence or absence of toxic genes for the city of Diwaniyah in southern Iraq. Sixty isolates were isolated from patients with cholera. The isolates included the center of the city and the surrounding rural areas. Biochemical and serological diagnosis. All the isolates were V. cholera serogroup O 1 of the serotyping Ogawa in biotype El Tor. Genetic testing was carried out using PCR technique and base on the presence or absence of toxin genes. Three genotypes were identified for the region

Sleeve gastrectomy or gastric bypass as revisional bariatric procedures: retrospective evaluation of outcomes

A considerable number of patients require revisional surgery after laparoscopic adjustable gastric banding (LAGB). Studies that compared the outcomes of revisional sleeve gastrectomy (r-SG) and revisional Roux-en-Y gastric bypass (r-RYGB) after failed LAGB are scarce in the literature. Our objective was to determine whether significant differences exist in outcomes between r-SG and r-RYGB after failed LAGB. From 2005 to 2012, patients who underwent laparoscopic r-SG and r-RYGB after failed LAGB were retrospectively compared and analyzed. Data included demographics, indication for revision, operative time, hospital stay, conversion rate, percentage excess weight loss (%EWL), and morbidity and mortality. Out of 693 bariatric procedures, 42 r-SG and 53 r-RYGB were performed. The median preoperative weight (107.7 and 117.7 kg, respectively, p = 0.02) and body mass index (BMI) (38.5 vs. 43.2 kg/m(2), respectively, p = 0.01) were statistically significantly lower in r-SG than in r-RYGB. The mean operative time and median hospital stay were significantly shorter in r-SG than in r-RYGB (108.4 vs. 161.2 min, p < 0.01) (2 vs. 3 days, p = 0.02), respectively. One patient underwent conversion to open surgery after r-RYGB (p = 0.5). The reoperation rate was lower in r-SG than in r-RYGB (0.0 vs. 3.8 %, p = 0.5). There was one postoperative leak in the r-RYGB, and the overall complication rate was significantly lower in r-SG patients than in r-RYGB patients (7.1 vs. 20.8 %, p = 0.05). The mean follow-up was significantly shorter in the r-SG group (9.8 vs. 29.3 months, p < 0.01). However, the mean postoperative BMI was not different at 1 year (32.3 vs. 34.7, p = 0.29) as well as mean %EWL was (47.4 vs. 45.6 %, p = 0.77). Both r-SG and r-RYGB are safe procedures with similar outcomes in terms of %EWL. As a result of the long-term potential nutritional complication of r-RYGB, r-SG may be a better option in this group of patients. Longer follow-up is needed

Therapeutic Effect of Low-Molecular Weight Heparin and Incidence of Lower Limb Deep Venous Thrombosis and Pulmonary Embolism After Laparoscopic Bariatric Surgery

Background:The aim of our study was to determine the therapeutic effect of low-molecular weight heparin after laparoscopic Roux-en-Y gastric bypass.Methods:We prospectively analyzed data of 39 patients who underwent Roux-en-Y gastric bypass from 1093 consecutive patients who underwent bariatric procedures from May 1999 to May 2012. All patients were given 40 mg enoxaparin subcutaneously once daily preoperatively and continued for 5 days.Results:There were 31 females. Mean age was 32.48 years and mean body mass index was 44.59 kg/m(2). Only 46.1% of patients reached the defined therapeutic dose on the second day and 41% on the fifth day. One fatal pulmonary embolism was recorded (1/1093, 0.09%) in the entire series.Conclusions:Anti-Xa surveillance did not correlate strongly with outcome. Further studies are required for proper dose adjustments of low-molecular weight heparin in these obese patients and whether anti-Xa monitoring should be continued