The impact of new signals on precise marine navigation - initial results from an experiment in Harwich Harbour

The General Lighthouse Authorities of the United Kingdom and Ireland (GLAs) are supporting a project at University College London (UCL) to study whether it is possible to meet the International Maritime Organisation’s (IMO) future requirements for port and harbour approach using future GNSS constellations, as detailed in IMO resolution A.915. This paper presents the results of a trial focusing on the accuracy, integrity, availability and continuity of port navigation, port approach, and docking. Abstract The required accuracy for docking is 0.1 m (95\%), which currently necessitates the use of Real Time Kinematic (RTK) processing. We consider the single-epoch geometry-based approach, which is robust against loss of lock and will fully benefit from the additional satellites. The trial was held at the beginning of May 2008 and saw THV Alert navigate into Harwich Harbour while satellite observation data were recorded from the vessel and from shore-based reference stations. Additional data were obtained from nearby Ordnance Survey reference stations, and two total stations were used to track the vessel’s passage to provide a truth model. Several modernised GPS satellites were tracked. The data were processed under different scenarios, using software developed at UCL, and the positioning performance analysed. Abstract Providing integrity for single-epoch RTK is particularly difficult. The identification of phase observation outliers is not possible before the integer ambiguities are resolved, but an undetected outlier could prevent successful ambiguity resolution. However, it will not always be necessary to fix every ambiguity to achieve the required precision, particularly with a multi-GNSS constellation. This paper introduces a new algorithm for partial ambiguity resolution in the presence of measurement bias that has been developed and tested at UCL.  This algorithm results in an improved ambiguity resolution success rate at the expense of computation time

The synthesis, characterisation and functional testing of metal oxide thin films

This thesis is concerned with the deposition of titanium dioxide thin films using chemical vapour deposition (CVD). The work emphasises the influence of deposition parameters on the properties of the resultant film. The materials have been designed with a wide range of potential applications in mind, from air and water purification to energy production and medical implant devices. Where possible, tests have been conducted to assess the efficacy of the material for these applications. The first chapter highlights a number of technologically important applications of titanium dioxide in order to demonstrate the motivation for research in this area. Some theoretical concepts are presented which are fundamental to understanding the behaviour of titanium dioxide. The principles behind chemical vapour deposition and the photocatalytic tests used in this work are discussed. The second chapter focusses on the use of three different metal substrates in TiO2 CVD. Firstly, the phase of TiO2 deposited on steel substrates was investigated. It was shown that the grade of steel had little influence with predominantly anatase films being formed in the vast majority of areas analysed. Since each grade of steel has different mechanical properties and is used in different applications, this work demonstrates that the photocatalytic properties of anatase films can be endowed to a large range of products. Secondly, TiO2 was shown to be adherent to a flexible substrate, namely aluminium foil. It was demonstrated from XPS analysis that aluminium ions did not diffuse into the TiO2, which remained photocatalytically active. A photocatalyst on a lightweight, flexible substrate offers several advantages over glass which has been the most frequently employed substrate to date. Thirdly, titanium dioxide was coated onto an alloy of cobalt, chromium and molybdenum, CoCrMo. The alloy is of interest for biomedical implants but suffers from poor biocompatability. By coating its surface with TiO2, it was shown to enhance osteogenic differentiation. Chapter three investigates nitrogen doped titanium dioxide for its potential as a visible light photocatalyst. A novel synthetic strategy was employed in which the amount of oxygen precursor was varied to determine if this would affect the position of the nitrogen in the titanium dioxide crystal structure. Differences were observed in the nitrogen XPS signal, the absorption profile, surface morphology and photocatalytic activity under both UV and visible irradiation. Visible light activity was observed for a sample made with lower amounts of oxygen precursor under UV and visible light. Finally, brookite, a rare, metastable form of titanium dioxide, was formed by atmospheric pressure chemical vapour deposition, APCVD. A brief literature review discusses the potential applications and some of the previously employed synthetic routes to brookite formation. Three sets of conditions are reported for the first known synthesis of brookite by atmospheric pressure chemical vapour deposition. A possible mechanism for brookite formation is hypothesised. This work concludes with a summary of the key findings from the experimental work and possible avenues for further research

A novel route to Pt-Bi2O3 composite thin films and their application in photo-reduction of water

A novel homoleptic bismuth(III) β-diketonate (dibenzoylmethane – dbm) complex [Bi(dbm)3]2 has been used as a precursor to thin films of crystalline β-Bi2O3, and hexachloroplatinic acid (H2PtCl6·6H2O) has been demonstrated as a suitable precursor for deposition of platinum nanoparticles, both deposited via aerosol-assisted chemical vapour deposition (AACVD). Thin films of Pt–Bi2O3 were co-deposited from a mixture of [Bi(dbm)3]2 and H2PtCl6·6H2O; the introduction of Pt particles into β-Bi2O3 causes hydrogen to be evolved during photolysis of water over the composite material, a property not found for Pt particles or β-Bi2O3 alone

Cancer incidence in British vegetarians

Background: Few prospective studies have examined cancer incidence among vegetarians. Methods: We studied 61 566 British men and women, comprising 32 403 meat eaters, 8562 non-meat eaters who did eat fish ('fish eaters') and 20 601 vegetarians. After an average follow-up of 12.2 years, there were 3350 incident cancers of which 2204 were among meat eaters, 317 among fish eaters and 829 among vegetarians. Relative risks (RRs) were estimated by Cox regression, stratified by sex and recruitment protocol and adjusted for age, smoking, alcohol, body mass index, physical activity level and, for women only, parity and oral contraceptive use. Results: There was significant heterogeneity in cancer risk between groups for the following four cancer sites: stomach cancer, RRs (compared with meat eaters) of 0.29 (95% CI: 0.07–1.20) in fish eaters and 0.36 (0.16–0.78) in vegetarians, P for heterogeneity=0.007; ovarian cancer, RRs of 0.37 (0.18–0.77) in fish eaters and 0.69 (0.45–1.07) in vegetarians, P for heterogeneity=0.007; bladder cancer, RRs of 0.81 (0.36–1.81) in fish eaters and 0.47 (0.25–0.89) in vegetarians, P for heterogeneity=0.05; and cancers of the lymphatic and haematopoietic tissues, RRs of 0.85 (0.56–1.29) in fish eaters and 0.55 (0.39–0.78) in vegetarians, P for heterogeneity=0.002. The RRs for all malignant neoplasms were 0.82 (0.73–0.93) in fish eaters and 0.88 (0.81–0.96) in vegetarians (P for heterogeneity=0.001). Conclusion: The incidence of some cancers may be lower in fish eaters and vegetarians than in meat eaters

Alcohol Consumption-Related Metabolites in Relation to Colorectal Cancer and Adenoma: Two Case-Control Studies Using Serum Biomarkers

Alcohol is a known carcinogen that may be associated with colorectal cancer. However, most epidemiologic studies assess alcoholic beverage consumption using self-reported data, leading to potential exposure misclassification. Biomarkers of alcohol consumption may provide an alternative, complementary approach that reduces misclassification and incorporates individual differences in alcohol metabolism. Therefore, we evaluated the relationship between previously identified alcohol consumption-related metabolites and colorectal cancer and adenoma using serum metabolomics data from two studies. Data on colorectal cancer were obtained from a nested case-control study of 502 US adults (252 cases, 250 controls) within the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Data on colorectal adenoma were obtained from a case-control study of 197 US adults (120 cases, 77 controls) from the Navy Colon Adenoma Study. Unconditional multivariable logistic regression models were fit to calculate odds ratios (OR) and 95% confidence intervals (CI) for eight alcohol consumption-related metabolites identified in a previous analysis: ethyl glucuronide; 4-androstene-3beta,17beta-diol disulfate 1; 5-alpha-androstan-3beta,17beta-diol disulfate; 16-hydroxypalmitate; bilirubin (E,Z or Z,E); cyclo (-leu-pro); dihomo-linoleate (20:2n6); and palmitoleate (16:1n7). We found no clear association between these alcohol consumption-related metabolites and either endpoint. However, we did observe an inverse association between cyclo (-leu-pro) and colorectal adenoma that was only observed in the highest metabolite quantile (OR 4th vs. 1st Quantile = 0.30, 95% CI: 0.12–0.78; P-trend = 0.047), but no association for colorectal cancer. In conclusion, there were no adverse associations between alcohol consumption-related metabolites and colorectal cancer or adenoma

Levosimendan for the prevention of acute organ dysfunction in sepsis

BACKGROUND Levosimendan is a calcium-sensitizing drug with inotropic and other properties that may improve outcomes in patients with sepsis. METHODS We conducted a double-blind, randomized clinical trial to investigate whether levosimendan reduces the severity of organ dysfunction in adults with sepsis. Patients were randomly assigned to receive a blinded infusion of levosimendan (at a dose of 0.05 to 0.2 μg per kilogram of body weight per minute) for 24 hours or placebo in addition to standard care. The primary outcome was the mean daily Sequential Organ Failure Assessment (SOFA) score in the intensive care unit up to day 28 (scores for each of five systems range from 0 to 4, with higher scores indicating more severe dysfunction; maximum score, 20). Secondary outcomes included 28-day mortality, time to weaning from mechanical ventilation, and adverse events. RESULTS The trial recruited 516 patients; 259 were assigned to receive levosimendan and 257 to receive placebo. There was no significant difference in the mean (±SD) SOFA score between the levosimendan group and the placebo group (6.68±3.96 vs. 6.06±3.89; mean difference, 0.61; 95% confidence interval [CI], −0.07 to 1.29; P=0.053). Mortality at 28 days was 34.5% in the levosimendan group and 30.9% in the placebo group (absolute difference, 3.6 percentage points; 95% CI, −4.5 to 11.7; P=0.43). Among patients requiring ventilation at baseline, those in the levosimendan group were less likely than those in the placebo group to be successfully weaned from mechanical ventilation over the period of 28 days (hazard ratio, 0.77; 95% CI, 0.60 to 0.97; P=0.03). More patients in the levosimendan group than in the placebo group had supraventricular tachyarrhythmia (3.1% vs. 0.4%; absolute difference, 2.7 percentage points; 95% CI, 0.1 to 5.3; P=0.04). CONCLUSIONS The addition of levosimendan to standard treatment in adults with sepsis was not associated with less severe organ dysfunction or lower mortality. Levosimendan was associated with a lower likelihood of successful weaning from mechanical ventilation and a higher risk of supraventricular tachyarrhythmia. (Funded by the NIHR Efficacy and Mechanism Evaluation Programme and others; LeoPARDS Current Controlled Trials number, ISRCTN12776039.

Long-term effects of once-only flexible sigmoidoscopy screening after 17 years of follow-up: the UK Flexible Sigmoidoscopy Screening randomised controlled trial

National Institute for Health Research Efficacy and Mechanism Evaluation

Feasibility and acceptability of breath research in primary care: a prospective, cross-sectional, observational study.

OBJECTIVES: To examine the feasibility and acceptability of breath research in primary care. DESIGN: Non-randomised, prospective, mixed-methods cross-sectional observational study. SETTING: Twenty-six urban primary care practices. PARTICIPANTS: 1002 patients aged 18-90 years with gastrointestinal symptoms. MAIN OUTCOME MEASURES: During the first 6 months of the study (phase 1), feasibility of patient enrolment using face-to-face, telephone or SMS-messaging (Short Message Service) enrolment strategies, as well as processes for breath testing at local primary care practices, were evaluated. A mixed-method iterative study design was adopted and outcomes evaluated using weekly Plan-Do-Study-Act cycles, focus groups and general practitioner (GP) questionnaires.During the second 6 months of the study (phase 2), patient and GP acceptability of the breath test and testing process was assessed using questionnaires. In addition a 'single practice' recruitment model was compared with a 'hub and spoke' centralised recruitment model with regards to enrolment ability and patient acceptability.Throughout the study feasibility of the collection of a large number of breath samples by clinical staff over multiple study sites was evaluated and quantified by the analysis of these samples using mass spectrometry. RESULTS: 1002 patients were recruited within 192 sampling days. Both 'single practice' and 'hub and spoke' recruitment models were effective with an average of 5.3 and 4.3 patients accrued per day, respectively. The 'hub and spoke' model with SMS messaging was the most efficient combined method of patient accrual. Acceptability of the test was high among both patients and GPs. The methodology for collection, handling and analysis of breath samples was effective, with 95% of samples meeting quality criteria. CONCLUSIONS: Large-scale breath testing in primary care was feasible and acceptable. This study provides a practical framework to guide the design of Phase III trials examining the performance of breath testing in primary care

Augmenting the 6-3-5 method with design information

This paper describes a comparative study between the 6-3-5 Method and the ICR Grid. The ICR Grid is an evolved variant of 6-3-5 intended to better integrate information into the concept generation process. Unlike a conventional 6-3-5 process where participants continually sketch concepts, using the ICR Grid (the name derived from its Inform, Create, Reflect activities and structured, grid-like output) participants are additionally required to undertake information search tasks, use specific information items for concept development, and reflect on the merit of concepts as the session progresses. The results indicate that although the quantity of concepts was lower, the use of information had a positive effect in a number of areas, principally the quality and variety of output. Although grounded in the area of product development, this research is applicable to any organisation undertaking idea generation and problem solving. As well as providing insights on the transference of information to concepts, it holds additional interest for studies on the composition and use of digital libraries