CORRELACIÓN ENTRE CARGA DE TRABAJO, SÍNDROME DE BURNOUT Y CALIDAD DE VIDA EN UNA UNIDAD DE CRÍTICOS

Objetives To detect Burnout Syndrome in nurses working in the resuscitation unit; Assessing their life quality, and correlating work load, Burnout Syndrome and life quality. Methods Descriptive and cross section study. Sample: Nursing personnel of the resuscitation unit at the CHUS hospital. Two questionnaires were used: Test of Life quality, Satisfaction and Pleasure, and Maslach Burnout Inventory (MBI). Results According to the MBI average obtained in the three sections: Emotional Tiredness, Depersonalization, and Personal Fulfillment, the following facts were observed: On average a higher MBI score in women than in men, as well as a higher score in married persons than in singles. Emotional tiredness and personal fulfillment are lower in men than in women. Meanwhile, depersonalization is higher in men. Conclusions Personnel with 3 to 6 years of experience in the unit: higher emotional tiredness; from 6 to 9 years: Higher level of depersonalization; More than 9 years: maximum level of personal fulfillment.Objetivos Detectar Síndrome de Burnout entre los DUE de Reanimación; evaluar calidad de vida y correlacionar carga de trabajo, S. Burnout y calidad de vida. Métodos Estudio descriptivo y transversal. Muestra: plantilla de DUE de Reanimación CHUS. Se emplearon dos cuestionarios: Test de Calidad de Vida, Satisfacción y Placer y el Maslach Burnout Inventory (MBI). Resultados Según la media obtenida del MBI en los tres apartados (cansancio emocional, despersonalización, realización personal) se observó: una media de puntuación del MBI superior en la mujer que en el hombre; mayor en casados que en solteros. El cansancio emocional y la realización personal son menores en el hombre que en la mujer y la despersonalización es superior en el hombre. Conclusiones De 3 a 6 años, mayor cansancio emocional; de 6 a 9, mayor nivel de despersonalización; personal con más de 9 años de antigüedad en el servicio, máximo grado de realización personal

Single Nucleotide Polymorphisms in the Wnt and BMP Pathways and Colorectal Cancer Risk in a Spanish Cohort

BACKGROUND: Colorectal cancer (CRC) is considered a complex disease, and thus the majority of the genetic susceptibility is thought to lie in the form of low-penetrance variants following a polygenic model of inheritance. Candidate-gene studies have so far been one of the basic approaches taken to identify these susceptibility variants. The consistent involvement of some signaling routes in carcinogenesis provided support for pathway-based studies as a natural strategy to select genes that could potentially harbour new susceptibility loci. METHODOLOGY/PRINCIPAL FINDINGS: We selected two main carcinogenesis-related pathways: Wnt and BMP, in order to screen the implicated genes for new risk variants. We then conducted a case-control association study in 933 CRC cases and 969 controls based on coding and regulatory SNPs. We also included rs4444235 and rs9929218, which did not fulfill our selection criteria but belonged to two genes in the BMP pathway and had consistently been linked to CRC in previous studies. Neither allelic, nor genotypic or haplotypic analyses showed any signs of association between the 37 screened variants and CRC risk. Adjustments for sex and age, and stratified analysis between sporadic and control groups did not yield any positive results either. CONCLUSIONS/SIGNIFICANCE: Despite the relevance of both pathways in the pathogenesis of the disease, and the fact that this is indeed the first study that considers these pathways as a candidate-gene selection approach, our study does not present any evidence of the presence of low-penetrance variants for the selected markers in any of the considered genes in our cohort