1,955 research outputs found
Brain muscarinic cholinergic receptors in Huntington's disease
Muscarinic cholinergic receptors and choline acetyltransferase (ChAT) activity were studied in postmortem brain tissue from patients with Huntington's disease and matched control subjects. In comparison with controls, reductions in ChAT activity were found in the hippocampus, but not in the temporal cortex in Huntington's disease. Patients with Huntington's disease showed reduced densities of the total number of muscarinic receptors and of M-2 receptors in the hippocampus while the density of M-1 receptors was unaltered. Muscarinic receptor binding was unchanged in the temporal cortex. These results indicate a degeneration in Huntington's disease of the septo-hippocampal cholinergic pathway, but no impairment of the innominato-cortical cholinergic system
IMPLEMENTASI PENGEMBANGAN SDM PADA KINERJA KARYAWAN PENJUALAN PT AKUSARA KABUPATEN GROBOGAN
Human resource development is the most important factor for a company that is used to increase employee performance productivity and expand employee capacity. This research aims to analyze and find out the implementation of human resource development on the performance of sales employees at PT Akusara. Research methods use qualitative methods by conducting interviews with objects to obtain the necessary information and data. The results of this research show that the Human Resource Development that has been implemented at Akusara PT is by performing 3 techniques namely Needs Analysis, Program Design and Evaluation. The research results to refer to the perspective of the research object are sales employees with a working time of less than 1 year and sales workers with working time over 1 year. Where both explain that with the development of human resources this can develop the ability of sales employees in particular in achieving the sales targets set by the company
Les performances des maisons d' opΓ©ra : une explication statistique
In this paper we try to explain opera houses performances in terms of financial autonomy and occupancy rate. In order to do that, we propose quantifications of variables representing artistic policy, production policy and main environmental components such as theater size, intensity of competition, economic conditions and strength and duration of local lyric tradition. The statistical analysis is done on a sample of 62 opera houses. It shows that environmental factors play the central role in the explanation of performances. In particular, houses that are the less constraint by local lyric tradition display the best performances. Two cases illustrate these conclusions: the Los Angeles Opera and the Berlin Staatsoper.Opera house management; Performance criteria; Financial autonomy; Occupancy rate; Lyric tradition; Historical explanation of performance
KOMPETENSI GURU DALAM PERSPEKTIF AL-QURβAN (TAFSIR SURAH AL-BAQARAH AYAT 67-71)
ABSTRAK
Guru merupakan salah satu komponen penting dalam proses pembelajaran
di kelas. Guru bukan hanya bisa mengajar dan menyampaikan ilmunya, namun
guru juga dituntut untuk mempunyai kompetensi. Kompetensi guru merupakan
seperangkat pengetahuan, keterampilan dan perilaku yang harus dimiliki, dihayati,
dikuasai dan diaktualisasikan oleh seorang guru dalam melaksanakan tugas
keprofesionalannya. Kajian ini dilatarbelakangi oleh masalah-masalah pendidikan
yang terjadi khususnya di Indonesia, yang salah satunya tertuju pada seorang
guru. Guru menduduki posisi sebagai penyampai informasi dan mengembangkan
karakter, karena ia yang melakukan interaksi langsung dengan peserta didik.
Disinilah kualitas pendidikan terbentuk berbanding lurus dengan kualitas
pembelajaran yang dilaksanakan oleh kualitas seorang guru. Ditambah adanya
pandangan bahwa siapapun bisa menjadi guru asalkan ia berpengetahuan serta
kekurangan guru di daerah terpencil, ini memberikan peluang untuk mengangkat
seseorang yang kurang mempunyai kompetensi untuk menjadi guru. Adapun
rumusan masalah yang dimaksud oleh penulis yaitu; Bagaimana Kompetensi guru
dalam prespektif al-Qurβan Surah al-Baqarah ayat 67-71. Dengan tujuan penulis
dapat mengetahui tentang kompetensi-kompetensi guru dalam prespektif al-
Qurβan Surah al-Baqarah ayat 67-71 tersebut. Penelitian ini merupakan penelitian
yang bersifat kualitatif deskriptif, yaitu metode penelitian yang berusaha
menggambarkan dan menginterpretasi objek sesuai dengan apa adanya.
Tujuannya adalah menggambarkan secara sistematis dan karakteristik objek yang
diteliti secara tepat. Jika dilihat dari jenis penelitian, penelitian ini merupakan
jenis penelitian kajian pustaka (Library Research). Peneliti menggunakan dua
kitab tafsir dengan mengkomparasikan tafsir al-Misbah dan al-Azhar yang
diharapakan dapat memperluas dan memperdalam pemahaman tentang redaksi
ayat yang hendak diteiti. Setelah dilakukan kajian secara mendalam, hasil dari
penelitian ini menunjukkan bahwa kompetensi guru menurut al-Qurβan surah al-
Baqarah ayat 67-71 yaitu; guru hendaknya memiliki beberapa kompetensi,
diantaranya memiliki kesabaran dalam mengajar (kompetensi kepribadian),
kejujuran guru (kompetensi kepribadian), penguasaan materi (kompetensi
profesional) mengetahui karakter peserta didik (kompetensi pedagogik),
kecakapan dalam berkomunikasi (kompetensi sosial).
Kata kunci : Kompetensi Guru, al-Qurβan, Al-Baqarah ayat 67-7
Making contested futures: a politics of designing with people
This PhD research explores how collaborative relationships and capacities for critical knowledge making emerge and are formed through embedded, situated design with people. It focuses especially on designing in the context of working for social and political change. I conducted the project as an embedded designer-researcher with Critical Resistance (CR), a US-based grassroots organization seeking to end reliance on the interconnected systems of prisons, policing, surveillance, and other mechanisms for control and confinement. Reflecting on over two years of work with CR members, the research proposes the importance of attention to the dynamic situatedness of being a designer working with others in participatory and collaborative design, and to the specific contexts that inform and are created through such work. This research builds on scholarship in Participatory Design, Service Design, and feminist and critical epistemology that emphasizes the value of collaborative identification of concerns and possibilities at multiple scales and also explores questions of power, position, and the socio-material and political nature of working with groups to make things and ideas. I suggest that collaborative relationships created through an ongoing practice of doing work together, and a designer’s capacities to be present for it, are a critical component of shaping and understanding participatory practices and what they can generate. In my practice with CR, what we designed together both produced, and was made possible by, how we created ways of working together over time. My capacities and position as a designer in relationship to members’ work were determined by what was of use to the organizing, and through the means we made for sharing ideas, strategies, and goals. In this doctoral submission I argue for an approach to practice that prioritizes what I call “design co-authorship” in which collaborators shape both the contexts for designing and what is designed in the process of creating a shared practice. This requires a deep and explicit engagement by all participants with the dynamic mess of collaboration, including attention to the contradictions, differences, and open questions that emerge and become part of designing together. Working in such a shared practice is, ultimately, a way of creating not just artifacts, systems, or services, but collective knowing and action. Through these ontological and epistemological arguments, I assert that it is the relationships participants create and the knowledge made through them that come to define how designing matters in participatory and collaborative design
Intrasellar rupture of a paraclinoid aneurysm with subarachnoid hemorrhage: usefulness of MR imaging in diagnosis
Characterization of paraclinoid aneurysms may be difficult because of the complexity of anatomic structures involved, and differentiation between intradural and extradural lesions is crucial. We report a case of a patient with a unique presentation of a paraclinoid aneurysm with intrasellar hemorrhage in which the presence of intrasellar blood and the relationship of the paraclinoid aneurysmal neck and sac to the dural rings were elegantly demonstrated on MR imaging and were critical in choosing the target lesion for treatment
ΠΠ·ΡΡΠ΅Π½ΠΈΠ΅ Π°Π΄ΡΠΎΡΠ±ΡΠΈΠΈ ΡΠ΅Ρ Π½Π΅ΡΠΈΡ-99ΠΌ Π½Π° ΠΎΠΊΡΠΈΠ΄Π΅ Π°Π»ΡΠΌΠΈΠ½ΠΈΡ ΠΈΠ· ΡΡΠ΅Π΄Ρ ΠΌΠ΅ΡΠΈΠ»ΡΡΠΈΠ»ΠΊΠ΅ΡΠΎΠ½Π° Π² ΡΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΡ ΠΈ Π΄ΠΈΠ½Π°ΠΌΠΈΡΠ΅ΡΠΊΠΈΡ ΡΡΠ»ΠΎΠ²ΠΈΡΡ
ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Π° Π°Π΄ΡΠΎΡΠ±ΡΠΈΡ ΡΠΊΡΡΡΠ°Π³ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ ΠΌΠ΅ΡΠΈΠ»ΡΡΠΈΠ»ΠΊΠ΅ΡΠΎΠ½ΠΎΠΌ 99mΠ’Ρ Π½Π° Π³Π°ΠΌΠΌΠ°-ΠΎΠΊΡΠΈΠ΄Π΅ Π°Π»ΡΠΌΠΈΠ½ΠΈΡ Ρ ΡΠ°Π·Π»ΠΈΡΠ½ΠΎΠΉ ΡΠ-ΡΠΎΡΠΌΠΎΠΉ Π² ΡΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈ Π΄ΠΈΠ½Π°ΠΌΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΡΠ»ΠΎΠ²ΠΈΡΡ
ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ ΠΏΡΠΎΡΠ΅ΡΡΠ°. ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Ρ ΠΊΠΎΡΡΡΠΈΡΠΈΠ΅Π½ΡΡ ΡΠ°ΡΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ 99mΠ’Ρ Π² ΡΠΈΡΡΠ΅ΠΌΠ΅ ΠΌΠ΅ΡΠΈΠ»ΡΡΠΈΠ»ΠΊΠ΅ΡΠΎΠ½ - 99mΠ’Ρ - ΠΎΠΊΡΠΈΠ΄ Π°Π»ΡΠΌΠΈΠ½ΠΈΡ. Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ ΠΌΠ°ΠΊΡΠΈΠΌΠ°Π»ΡΠ½Π°Ρ ΡΠΎΡΠ±ΡΠΈΠΎΠ½Π½Π°Ρ Π΅ΠΌΠΊΠΎΡΡΡ ΠΏΠΎ ΡΠ°Π΄ΠΈΠΎΠ½ΡΠΊΠ»ΠΈΠ΄Ρ Π΄ΠΎΡΡΠΈΠ³Π°Π΅ΡΡΡ Π½Π° ΠΎΠΊΡΠΈΠ΄Π°Ρ
Ρ ΡΠ-ΡΠΎΡΠΌΠΎΠΉ 4,5_6. Π ΡΡΠΈΡ
ΠΆΠ΅ ΡΡΠ»ΠΎΠ²ΠΈΡΡ
Π½Π°Π±Π»ΡΠ΄Π°ΡΡΡΡ Π½Π°ΠΈΠΌΠ΅Π½ΡΡΠΈΠ΅ ΠΏΠΎΡΠ΅ΡΠΈ 99mΠ’Ρ ΠΏΡΠΈ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠΈ Π΅Π³ΠΎ Π°Π΄ΡΠΎΡΠ±ΡΠΈΠΈ Π½Π° Ρ
ΡΠΎΠΌΠ°ΡΠΎΠ³ΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΊΠΎΠ»ΠΎΠ½ΠΊΠ΅ ΠΈ ΠΏΡΠΎΠΌΡΠ²ΠΊΠ΅ ΠΊΠΎΠ»ΠΎΠ½ΠΊΠΈ Π²ΠΎΠ΄ΠΎΠΉ, Π° ΡΠ°ΠΊΠΆΠ΅ Π½Π°ΠΈΠ±ΠΎΠ»ΡΡΠΈΠΉ Π²ΡΡ
ΠΎΠ΄ 99mΠ’Ρ (Π±ΠΎΠ»Π΅Π΅ 95 %) ΠΏΡΠΈ ΠΏΠΎΡΠ»Π΅Π΄ΡΡΡΠ΅ΠΌ Π΅Π³ΠΎ Π²ΡΠ΄Π΅Π»Π΅Π½ΠΈΠΈ Π² Π²ΠΈΠ΄Π΅ ΡΠ°ΡΡΠ²ΠΎΡΠ° Π½Π°ΡΡΠΈΡ ΠΏΠ΅ΡΡΠ΅Ρ
Π½Π΅ΡΠ°ΡΠ°,99mΠ’Ρ. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΠΎΠ±ΡΠ°Ρ ΠΏΡΠΎΠ΄ΠΎΠ»ΠΆΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΡ ΠΏΡΠΎΡΠ΅ΡΡΠ° ΠΎΡΠ΄Π΅Π»Π΅Π½ΠΈΡ 99mΠ’Ρ ΠΎΡ ΡΠΊΡΡΡΠ°Π³Π΅Π½ΡΠ° Π½Π΅ ΠΏΡΠ΅Π²ΡΡΠ°Π΅Ρ 20 ΠΌΠΈΠ½, ΡΡΠΎ ΡΠΎΠΏΠΎΡΡΠ°Π²ΠΈΠΌΠΎ Ρ Π²ΡΠ΅ΠΌΠ΅Π½Π΅ΠΌ ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΡ ΡΠ»ΡΠ°ΡΠ° 99mΠ’Ρ ΠΈΠ· ΡΡΠ°Π΄ΠΈΡΠΈΠΎΠ½Π½ΡΡ
ΡΠΎΡΠ±ΡΠΈΠΎΠ½Π½ΡΡ
Π³Π΅Π½Π΅ΡΠ°ΡΠΎΡΠΎΠ², ΠΈ, Π² ΠΊΠΎΠ½Π΅ΡΠ½ΠΎΠΌ ΠΈΡΠΎΠ³Π΅, ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠΈΠ²Π°Π΅Ρ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡ ΡΠΎΠ·Π΄Π°Π½ΠΈΡ ΡΠ΅ΡΡΡΡΠΎΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΡΡ
ΡΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈ ΡΠΈΡΡΡΡ
ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΡΡΠ² ΡΠ°Π΄ΠΈΠΎΡΠ°ΡΠΌΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ² 99mΠ’Ρ
Correction: A Guideline and Checklist for Initiating and Managing Clozapine Treatment in Patients with Treatment-Resistant Schizophrenia
This article was published online on June 27, 2022. An error was subsequently identified in the article, and the following correction should be noted: In the original publication, section 4.6, page 667, the reference cited in the first full sentence in column 2 and in Table 5 on the same page that read: βThis information can be used to optimize clozapine dosage (Table 5) [103].β βTable 5 Therapeutic drug monitoring (TDM)-informed decision-making algorithm for clozapine-treated patientsa [103]β βAdapted by permission from reference [103]β Should read: βThis information can be used to optimize clozapine dosage (Table 5) [104].β βTable 5 Therapeutic drug monitoring (TDM)-informed decision-making algorithm for clozapine-treated patientsa [104]β βAdapted by permission from reference [104]β The original article has been corrected. Β© The Author(s) 2022
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