356 research outputs found
Radio pulsar populations
The goal of this article is to summarize the current state of play in the
field of radio pulsar statistics. Simply put, from the observed sample of
objects from a variety of surveys with different telescopes, we wish to infer
the properties of the underlying sample and to connect these with other
astrophysical populations (for example supernova remnants or X-ray binaries).
The main problem we need to tackle is the fact that, like many areas of
science, the observed populations are often heavily biased by a variety of
selection effects. After a review of the main effects relevant to radio
pulsars, I discuss techniques to correct for them and summarize some of the
most recent results. Perhaps the main point I would like to make in this
article is that current models to describe the population are far from complete
and often suffer from strong covariances between input parameters. That said,
there are a number of very interesting conclusions that can be made concerning
the evolution of neutron stars based on current data. While the focus of this
review will be on the population of isolated Galactic pulsars, I will also
briefly comment on millisecond and binary pulsars as well as the pulsar content
of globular clusters and the Magellanic Clouds.Comment: 16 pages, 6 figures, to appear in Proceedings of ICREA Workshop on
The High-Energy Emission from Pulsars and their Systems, Sant Cugat, Spain,
2010 April 12-16 (Springer
Binary and Millisecond Pulsars at the New Millennium
We review the properties and applications of binary and millisecond pulsars.
Our knowledge of these exciting objects has greatly increased in recent years,
mainly due to successful surveys which have brought the known pulsar population
to over 1300. There are now 56 binary and millisecond pulsars in the Galactic
disk and a further 47 in globular clusters. This review is concerned primarily
with the results and spin-offs from these surveys which are of particular
interest to the relativity community.Comment: 59 pages, 26 figures, 5 tables. Accepted for publication in Living
Reviews in Relativity (http://www.livingreviews.org
Accelerated expansion from ghost-free bigravity: a statistical analysis with improved generality
We study the background cosmology of the ghost-free, bimetric theory of
gravity. We perform an extensive statistical analysis of the model using both
frequentist and Bayesian frameworks and employ the constraints on the expansion
history of the Universe from the observations of supernovae, the cosmic
microwave background and the large scale structure to estimate the model's
parameters and test the goodness of the fits. We explore the parameter space of
the model with nested sampling to find the best-fit chi-square, obtain the
Bayesian evidence, and compute the marginalized posteriors and mean
likelihoods. We mainly focus on a class of sub-models with no explicit
cosmological constant (or vacuum energy) term to assess the ability of the
theory to dynamically cause a late-time accelerated expansion. The model
behaves as standard gravity without a cosmological constant at early times,
with an emergent extra contribution to the energy density that converges to a
cosmological constant in the far future. The model can in most cases yield very
good fits and is in perfect agreement with the data. This is because many
points in the parameter space of the model exist that give rise to
time-evolution equations that are effectively very similar to those of the
CDM. This similarity makes the model compatible with observations as
in the CDM case, at least at the background level. Even though our
results indicate a slightly better fit for the CDM concordance model
in terms of the -value and evidence, none of the models is statistically
preferred to the other. However, the parameters of the bigravity model are in
general degenerate. A similar but perturbative analysis of the model as well as
more data will be required to break the degeneracies and constrain the
parameters, in case the model will still be viable compared to the
CDM.Comment: 42 pages, 9 figures; typos corrected in equations (2.12), (2.13),
(3.7), (3.8) and (3.9); more discussions added (footnotes 5, 8, 10 and 13)
and abstract, sections 4.2, 4.3 and 5 (conclusions) modified in response to
referee's comments; references added; acknowledgements modified; all results
completely unchanged; matches version accepted for publication in JHE
Binary and Millisecond Pulsars
We review the main properties, demographics and applications of binary and
millisecond radio pulsars. Our knowledge of these exciting objects has greatly
increased in recent years, mainly due to successful surveys which have brought
the known pulsar population to over 1700. There are now 80 binary and
millisecond pulsars associated with the disk of our Galaxy, and a further 103
pulsars in 24 of the Galactic globular clusters. Recent highlights have been
the discovery of the first ever double pulsar system and a recent flurry of
discoveries in globular clusters, in particular Terzan 5.Comment: 77 pages, 30 figures, available on-line at
http://www.livingreviews.org/lrr-2005-
Salvage Cryotherapy for Radiation-Recurrent Prostate Cancer: Outcomes and Complications
Potentially curative salvage options for radio-recurrent prostate cancer include prostatectomy, brachytherapy, high-intensity focused ultrasound, and cryotherapy. Salvage cryoablation technology, surgical technique, oncologic outcomes, and complication rates have improved dramatically over the past few decades, shifting this treatment modality from investigational status to an established therapeutic option. In this review, we focus on the most up-to-date oncologic and functional outcomes, as well as complications of salvage cryotherapy for radiation-recurrent prostate cancer
Predicting Progression of IgA Nephropathy: New Clinical Progression Risk Score
IgA nephropathy (IgAN) is a common cause of end-stage renal disease (ESRD) in Asia. In this study, based on a large cohort of Chinese patients with IgAN, we aim to identify independent predictive factors associated with disease progression to ESRD. We collected retrospective clinical data and renal outcomes on 619 biopsy-diagnosed IgAN patients with a mean follow-up time of 41.3 months. In total, 67 individuals reached the study endpoint defined by occurrence of ESRD necessitating renal replacement therapy. In the fully adjusted Cox proportional hazards model, there were four baseline variables with a significant independent effect on the risk of ESRD. These included: eGFR [HR = 0.96(0.95–0.97)], serum albumin [HR = 0.47(0.32–0.68)], hemoglobin [HR = 0.79(0.72–0.88)], and SBP [HR = 1.02(1.00–1.03)]. Based on these observations, we developed a 4-variable equation of a clinical risk score for disease progression. Our risk score explained nearly 22% of the total variance in the primary outcome. Survival ROC curves revealed that the risk score provided improved prediction of ESRD at 24th, 60th and 120th month of follow-up compared to the three previously proposed risk scores. In summary, our data indicate that IgAN patients with higher systolic blood pressure, lower eGFR, hemoglobin, and albumin levels at baseline are at a greatest risk of progression to ESRD. The new progression risk score calculated based on these four baseline variables offers a simple clinical tool for risk stratification
Combined explanations of B-physics anomalies: the sterile neutrino solution
In this paper we provide a combined explanation of charged- and neutral-current B-physics anomalies assuming the presence of a light sterile neutrino NR which contributes to the B \u2192 D(*)\u3c4\u3bd processes. We focus in particular on two simplified models, where the mediator of the flavour anomalies is either a vector leptoquark U1\u3bc 3c (3, 1, 2/3) or a scalar leptoquark S1 3c (3\uaf , 1, 1/3). We find that U1\u3bc can successfully reproduce the required deviations from the Standard Model while being at the same time compatible with all other flavour and precision observables. The scalar leptoquark instead induces a tension between Bs mixing and the neutral-current anomalies. For both states we present the limits and future projections from direct searches at the LHC finding that, while at present both models are perfectly allowed, all the parameter space will be tested with more luminosity. Finally, we study in detail the cosmological constraints on the sterile neutrino NR and the conditions under which it can be a candidate for dark matter
The primary headaches: genetics, epigenetics and a behavioural genetic model
The primary headaches, migraine with (MA) and without aura (MO) and cluster headache, all carry a substantial genetic liability. Familial hemiplegic migraine (FHM), an autosomal dominant mendelian disorder classified as a subtype of MA, is due to mutations in genes encoding neural channel subunits. MA/MO are considered multifactorial genetic disorders, and FHM has been proposed as a model for migraine aetiology. However, a review of the genetic studies suggests that the FHM genes are not involved in the typical migraines and that FHM should be considered as a syndromic migraine rather than a subtype of MA. Adopting the concept of syndromic migraine could be useful in understanding migraine pathogenesis. We hypothesise that epigenetic mechanisms play an important role in headache pathogenesis. A behavioural model is proposed, whereby the primary headaches are construed as behaviours, not symptoms, evolutionarily conserved for their adaptive value and engendered out of a genetic repertoire by a network of pattern generators present in the brain and signalling homeostatic imbalance. This behavioural model could be incorporated into migraine genetic research
Relativistic Binaries in Globular Clusters
Galactic globular clusters are old, dense star systems typically containing
10\super{4}--10\super{7} stars. As an old population of stars, globular
clusters contain many collapsed and degenerate objects. As a dense population
of stars, globular clusters are the scene of many interesting close dynamical
interactions between stars. These dynamical interactions can alter the
evolution of individual stars and can produce tight binary systems containing
one or two compact objects. In this review, we discuss theoretical models of
globular cluster evolution and binary evolution, techniques for simulating this
evolution that leads to relativistic binaries, and current and possible future
observational evidence for this population. Our discussion of globular cluster
evolution will focus on the processes that boost the production of hard binary
systems and the subsequent interaction of these binaries that can alter the
properties of both bodies and can lead to exotic objects. Direct {\it N}-body
integrations and Fokker--Planck simulations of the evolution of globular
clusters that incorporate tidal interactions and lead to predictions of
relativistic binary populations are also discussed. We discuss the current
observational evidence for cataclysmic variables, millisecond pulsars, and
low-mass X-ray binaries as well as possible future detection of relativistic
binaries with gravitational radiation.Comment: 88 pages, 13 figures. Submitted update of Living Reviews articl
Measurement and interpretation of same-sign W boson pair production in association with two jets in pp collisions at s = 13 TeV with the ATLAS detector
This paper presents the measurement of fducial and diferential cross sections for both the inclusive and electroweak production of a same-sign W-boson pair in association with two jets (W±W±jj) using 139 fb−1 of proton-proton collision data recorded at a centre-of-mass energy of √s = 13 TeV by the ATLAS detector at the Large Hadron Collider. The analysis is performed by selecting two same-charge leptons, electron or muon, and at least two jets with large invariant mass and a large rapidity diference. The measured fducial cross sections for electroweak and inclusive W±W±jj production are 2.92 ± 0.22 (stat.) ± 0.19 (syst.)fb and 3.38±0.22 (stat.)±0.19 (syst.)fb, respectively, in agreement with Standard Model predictions. The measurements are used to constrain anomalous quartic gauge couplings by extracting 95% confdence level intervals on dimension-8 operators. A search for doubly charged Higgs bosons H±± that are produced in vector-boson fusion processes and decay into a same-sign W boson pair is performed. The largest deviation from the Standard Model occurs for an H±± mass near 450 GeV, with a global signifcance of 2.5 standard deviations
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