Prevention of the onset of hyperglycaemia by extracts of Aloe barbadensis in rabbits treated with alloxan

The ability of a home-made aqueous extract of Aloe barbadensis to prevent the onset of alloxaninduced hyperglycaemia was examined and compared with that of a factory-produced gel. Three groupsof animals were administered 200 mg/kg body weight of alloxan intraperitoneally. A fourth group of animals was left uninjected. Animals in group 2 also received a uniform administration of 1 mg/ml twicedaily oral intake of Aloe gel (the home-made extract) commenced at the same time the alloxan was administered and continued thereafter for the next six days. Animals in group 3 were administered the factory-produced extract in a similar way as was done for animals in group 2. Plasma glucose levels at the end of the experiment were 142.50±6.28, 82.50±2.72, 88.17±1.92 and 94.17±1.51mg/dl for animals in groups 1, 2, 3 and 4, respectively. Alloxan administration possibly resulted in an increase of 51% in the plasma glucose level of animals in group 1 relative to animals in group 4 (

Chemical constituents and antioxidant activity of Alstonia boonei

The chemical composition and some antioxidant indices of Alstonia boonei stem-bark extract were evaluated. A. boonei was found to contain important minerals like calcium, phosphorus, iron, sodium, potassium, and magnesium. Alkaloids, tannins, saponins, flavonoids and cardiac glycosides were among the phytochemicals detected together with the important vitamin, ascorbic acid. DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging activity, total phenolic content and reducing power were41.58 ± 1.43 %, 2.09 ± 0.04 mg/g gallic acid equivalent and 0.32 ± 0.01 respectively. Against the backdrop of the many medicinal uses of the plant, the results of the present work indicate that phytochemicals, other than phenolics, the mineral elements and vitamin C may be the critical factors in the medicinal effects of A. boonei

Identification of a Novel Calotropis procera Protein That Can Suppress Tumor Growth in Breast Cancer through the Suppression of NF-κB Pathway

10.1371/journal.pone.0048514PLoS ONE712