The effects of man-marking on work intensity in small-sided soccer games

The aim of this study was to examine the effect of manipulating defensive rules: with and without man-marking (MM and NMM) on exercise intensity in 3 vs. 3 small-sided games (SSGs). Twelve adolescent soccer players (age: 16.2 ± 0.7 years; body mass: 55.7 ± 6.4 kg; body height: 1.70 ± 0.07 m) participated in this repeated measures study. Each participant performed in four different SSGs formats: 3 vs. 3 MM with and without goals and 3 vs. 3 NMM with and without goals. Each SSG lasted 3 x 4 minutes interspersed with 4 minutes passive recovery. The percentage heart rate reserve (%HRreserve) was recorded continuously during SSG and session-rating of perceived exertion (session-RPE) after the SSG. MANOVA showed that defensive rule had significant effects on intensity (F = 5.37, p < 0.01). Specifically, MM during SSG induced significantly higher %HRreserve compared to NMM (Goal: 80.5 vs. 75.7%; No goal: 80.5 vs. 76.1%; p < 0.05, effect size = 0.91-1.06), irrespective of the presence or absence of goals. However, only MM with the presence of goals induced significant higher session-RPE compared to NMM (7.1 vs. 6.0; p < 0.05, effect size = 1.36), whereas no difference in session-RPE was observed between MM and NMM (7.4 vs. 6.9; p > 0.05, effect size = 0.63) when no goals were used. Higher intra-class reliability and lower coefficient of variation values were also reported in MM as compared to NMM. This study in youth soccer players shows there is ~4.5% increase in heart rate response by using the man-marking in 3 vs. 3 SSG thus the intensity of SSG can be significantly increased when using man-marking tactics

Сучасний стан і шляхи подальшого розвитку вітчизняної вугільної промисловості

Викладено загальну характеристику вугільної промисловості України (порівняно з деякими іншими країнами), наведено динаміку основних показників вітчизняної вугільної галузі за останнє десятиріччя. Визначено найбільш актуальні проблеми розвитку галузі та заходи щодо їх вирішення.Изложена общая характеристика угольной промышленности Украины (в сравнении с некоторыми другими странами), приведена динамика основных показателей отечественной угольной отрасли за последнее десятилетие. Определены наиболее актуальные проблемы развития отрасли и меры по их решению.Coal mining of Ukraine is characterized (as compared with some other countries), dynamics of main native mining indices for the last ten years is demonstrated. The urgent problems of mining development have been identified and the ways to solve them as well

The Cryogenic Target for the G0^0 Experiment at Jefferson Lab

A cryogenic horizontal single loop target has been designed, built, tested and operated for the G$^0$ experiment in Hall C at Jefferson Lab. The target cell is 20 cm long, the loop volume is 6.5 l and the target operates with the cryogenic pump fully immersed in the fluid. The target has been designed to operate at 30 Hz rotational pump speed with either liquid hydrogen or liquid deuterium. The high power heat exchanger is able to remove 1000 W of heat from the liquid hydrogen, while the nominal electron beam with current of 40 $\mu$A and energy of 3 GeV deposits about 320 W of heat into the liquid. The increase in the systematic uncertainty due to the liquid hydrogen target is negligible on the scale of a parity violation experiment. The global normalized yield reduction for 40 $\mu$A beam is about 1.5 % and the target density fluctuations contribute less than 238 ppm (parts per million) to the total asymmetry width, typically about 1200 ppm, in a Q$^2$ bin.Comment: 27 pages, 14 figure

Rapid optimization of drug combinations for the optimal angiostatic treatment of cancer.

Drug combinations can improve angiostatic cancer treatment efficacy and enable the reduction of side effects and drug resistance. Combining drugs is non-trivial due to the high number of possibilities. We applied a feedback system control (FSC) technique with a population-based stochastic search algorithm to navigate through the large parametric space of nine angiostatic drugs at four concentrations to identify optimal low-dose drug combinations. This implied an iterative approach of in vitro testing of endothelial cell viability and algorithm-based analysis. The optimal synergistic drug combination, containing erlotinib, BEZ-235 and RAPTA-C, was reached in a small number of iterations. Final drug combinations showed enhanced endothelial cell specificity and synergistically inhibited proliferation (p &lt; 0.001), but not migration of endothelial cells, and forced enhanced numbers of endothelial cells to undergo apoptosis (p &lt; 0.01). Successful translation of this drug combination was achieved in two preclinical in vivo tumor models. Tumor growth was inhibited synergistically and significantly (p &lt; 0.05 and p &lt; 0.01, respectively) using reduced drug doses as compared to optimal single-drug concentrations. At the applied conditions, single-drug monotherapies had no or negligible activity in these models. We suggest that FSC can be used for rapid identification of effective, reduced dose, multi-drug combinations for the treatment of cancer and other diseases

Estimates of hypolimnetic oxygen deficits in ponds

Shallow tropical integrated culture ponds in the Pearl River Delta, China, have been found to stratify almost daily, with high organic loadings and dense algal growth. The dissolved oxygen (DO) concentration is super-saturated in the epilimnion and is under 2 mg/l in the hypolimnion (>1m). The compensation depth corresponds to twice the Secchi disk depth ranging from 50 to 80cm. As a result, little or no net oxygen is produced in the hypolimnion (>1m). The low DO concentration in the hypolimnion causes organic materials, such as unused organic wastes and senescent algae cells, to be incompletely oxidized, since the rate of oxygen consumption by oxidable matter in water is dependent on the dissolved oxygen concentration in water. This material becomes the source of hypolimnetic oxygen deficits (HOD) which can drive whole pond DO to a dangerously low level, should sudden destratification occur. An improved estimate of hypolimnetic oxygen deficits is introduced in this article, and the advantages of this method are discussed.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72126/1/j.1365-2109.1989.tb00341.x.pd

Oblique triangular antiferromagnetic phase in CsCu1−x_{1-x}Cox_xCl3_3

The spin-1/2 stacked triangular antiferromagnet CsCu$_{1-x}$Co$_x$Cl$_3$ with $0.015<x<0.032$ undergoes two phase transitions at zero field. The low-temperature phase is produced by the small amount of Co$^{2+}$ doping. In order to investigate the magnetic structures of the two ordered phases, the neutron elastic scattering experiments have been carried out for the sample with $x\approx 0.03$. It is found that the intermediate phase is identical to the ordered phase of CsCuCl$_3$, and that the low-temperature phase is an oblique triangular antiferromagnetic phase in which the spins form a triangular structure in a plane tilted from the basal plane. The tilting angle which is 42$^{\circ}$ at $T=1.6$ K decreases with increasing temperature, and becomes zero at $T_{\rm N2} =7.2$ K. An off-diagonal exchange term is proposed as the origin of the oblique phase.Comment: 6 pages, 7 figure

Discrete element framework for modelling extracellular matrix, deformable cells and subcellular components

This paper presents a framework for modelling biological tissues based on discrete particles. Cell components (e.g. cell membranes, cell cytoskeleton, cell nucleus) and extracellular matrix (e.g. collagen) are represented using collections of particles. Simple particle to particle interaction laws are used to simulate and control complex physical interaction types (e.g. cell-cell adhesion via cadherins, integrin basement membrane attachment, cytoskeletal mechanical properties). Particles may be given the capacity to change their properties and behaviours in response to changes in the cellular microenvironment (e.g., in response to cell-cell signalling or mechanical loadings). Each particle is in effect an 'agent', meaning that the agent can sense local environmental information and respond according to pre-determined or stochastic events. The behaviour of the proposed framework is exemplified through several biological problems of ongoing interest. These examples illustrate how the modelling framework allows enormous flexibility for representing the mechanical behaviour of different tissues, and we argue this is a more intuitive approach than perhaps offered by traditional continuum methods. Because of this flexibility, we believe the discrete modelling framework provides an avenue for biologists and bioengineers to explore the behaviour of tissue systems in a computational laboratory

A Bayesian view of the current status of dark matter direct searches

Bayesian statistical methods offer a simple and consistent framework for incorporating uncertainties into a multi-parameter inference problem. In this work we apply these methods to a selection of current direct dark matter searches. We consider the simplest scenario of spin-independent elastic WIMP scattering, and infer the WIMP mass and cross-section from the experimental data with the essential systematic uncertainties folded into the analysis. We find that when uncertainties in the scintillation efficiency of Xenon100 have been accounted for, the resulting exclusion limit is not sufficiently constraining to rule out the CoGeNT preferred parameter region, contrary to previous claims. In the same vein, we also investigate the impact of astrophysical uncertainties on the preferred WIMP parameters. We find that within the class of smooth and isotropic WIMP velocity distributions, it is difficult to reconcile the DAMA and the CoGeNT preferred regions by tweaking the astrophysics parameters alone. If we demand compatibility between these experiments, then the inference process naturally concludes that a high value for the sodium quenching factor for DAMA is preferred.Comment: 37 pages, 14 figures and 7 tables. Replacement for matching the version accepted for publicatio

Recent glitches detected in the Crab pulsar

From 2000 to 2010, monitoring of radio emission from the Crab pulsar at Xinjiang Observatory detected a total of nine glitches. The occurrence of glitches appears to be a random process as described by previous researches. A persistent change in pulse frequency and pulse frequency derivative after each glitch was found. There is no obvious correlation between glitch sizes and the time since last glitch. For these glitches $\Delta\nu_{p}$ and $\Delta\dot{\nu}_{p}$ span two orders of magnitude. The pulsar suffered the largest frequency jump ever seen on MJD 53067.1. The size of the glitch is $\sim$ 6.8 $\times 10^{-6}$ Hz, $\sim$ 3.5 times that of the glitch occured in 1989 glitch, with a very large permanent changes in frequency and pulse frequency derivative and followed by a decay with time constant $\sim$ 21 days. The braking index presents significant changes. We attribute this variation to a varying particle wind strength which may be caused by glitch activities. We discuss the properties of detected glitches in Crab pulsar and compare them with glitches in the Vela pulsar.Comment: Accepted for publication in Astrophysics & Space Scienc

Rare functional variants associated with antidepressant remission in Mexican-Americans: short title: antidepressant remission and pharmacogenetics in Mexican-Americans

Introduction: Rare genetic functional variants can contribute to 30-40% of functional variability in genes relevant to drug action. Therefore, we investigated the role of rare functional variants in antidepressant response. Method: Mexican-American individuals meeting the Diagnostic and Statistical Manual-IV criteria for major depressive disorder (MDD) participated in a prospective randomized, double-blind study with desipramine or fluoxetine. The rare variant analysis was performed using whole-exome genotyping data. Network and pathway analyses were carried out with the list of significant genes. Results: The Kernel-Based Adaptive Cluster method identified functional rare variants in 35 genes significantly associated with treatment remission (False discovery rate, FDR <0.01). Pathway analysis of these genes supports the involvement of the following gene ontology processes: olfactory/sensory transduction, regulation of response to cytokine stimulus, and meiotic cell cycleprocess. Limitations: Our study did not have a placebo arm. We were not able to use antidepressant blood level as a covariate. Our study is based on a small sample size of only 65 Mexican-American individuals. Further studies using larger cohorts are warranted. Conclusion: Our data identified several rare functional variants in antidepressant drug response in MDD patients. These have the potential to serve as genetic markers for predicting drug response. Trial Registration: ClinicalTrials.gov NCT00265291.Ma-Li Wong, Mauricio Arcos-Burgos, Sha Liu, Alice W. Licinio, Chenglong Yu, Eunice W.M. Chin, Wei-Dong Yao, Xin-Yun Lu, Stefan R. Bornstein, Julio Licini