Neutron Star Properties from an NJL Model Modified to Simulate Confinement

The NJL model has recently been extended with a method to simulate confinement. This leads in mean field approximation to a natural mechanism for the saturation of nuclear matter. We use the model to investigate the equation of state of asymmetric nuclear matter and then use it to compute the properties of neutron stars.Comment: 5 pages, 6 figures, to be published in the proceedings for QCD Down Under Workshop, Adelaide, March 10-19, 200

Expectation values of four-quark operators in pions

The values of four-quark operators averaged over pions are expressed through those averaged over vacuum. The specific values are obtained in the framework of the factorization assumption. For the condensates of the light quarks of the same flavour \bar q\Gamma q\bar q\Gamma q the scalar condensate is shown to be an order of magnitude larger than the other ones. The condensates containing the strange quarks \bar q q\bar s s appear to be only about twice smaller than those of the light quarks. The degeneracy of the ground state in the Nambu--Jona--Lasinio model is shown explicitly.Comment: 9 pages, no figures, typos correcte

Antiproton constraints on dark matter annihilations from internal electroweak bremsstrahlung

If the dark matter particle is a Majorana fermion, annihilations into two fermions and one gauge boson could have, for some choices of the parameters of the model, a non-negligible cross-section. Using a toy model of leptophilic dark matter, we calculate the constraints on the annihilation cross-section into two electrons and one weak gauge boson from the PAMELA measurements of the cosmic antiproton-to-proton flux ratio. Furthermore, we calculate the maximal astrophysical boost factor allowed in the Milky Way under the assumption that the leptophilic dark matter particle is the dominant component of dark matter in our Universe. These constraints constitute very conservative estimates on the boost factor for more realistic models where the dark matter particle also couples to quarks and weak gauge bosons, such as the lightest neutralino which we also analyze for some concrete benchmark points. The limits on the astrophysical boost factors presented here could be used to evaluate the prospects to detect a gamma-ray signal from dark matter annihilations at currently operating IACTs as well as in the projected CTA.Comment: 32 pages; 13 figure

Abnormal number of Nambu-Goldstone bosons in the color-asymmetric 2SC phase of an NJL-type model

We consider an extended Nambu--Jona-Lasinio model including both (q \bar q)- and (qq)-interactions with two light-quark flavors in the presence of a single (quark density) chemical potential. In the color superconducting phase of the quark matter the color SU(3) symmetry is spontaneously broken down to SU(2). If the usual counting of Goldstone bosons would apply, five Nambu-Goldstone (NG) bosons corresponding to the five broken color generators should appear in the mass spectrum. Unlike that expectation, we find only three gapless diquark excitations of quark matter. One of them is an SU(2)-singlet, the remaining two form an SU(2)-(anti)doublet and have a quadratic dispersion law in the small momentum limit. These results are in agreement with the Nielsen-Chadha theorem, according to which NG-bosons in Lorentz-noninvariant systems, having a quadratic dispersion law, must be counted differently. The origin of the abnormal number of NG-bosons is shown to be related to a nonvanishing expectation value of the color charge operator Q_8 reflecting the lack of color neutrality of the ground state. Finally, by requiring color neutrality, two massive diquarks are argued to become massless, resulting in a normal number of five NG-bosons with usual linear dispersion laws.Comment: 13 pages, 4 figures, revtex

Observation of the Higgs Boson of strong interaction via Compton scattering by the nucleon

It is shown that the Quark-Level Linear $\sigma$ Model (QLL$\sigma$M) leads to a prediction for the diamagnetic term of the polarizabilities of the nucleon which is in excellent agreement with the experimental data. The bare mass of the $\sigma$ meson is predicted to be $m_\sigma=666$ MeV and the two-photon width $\Gamma(\sigma\to\gamma\gamma)=(2.6\pm 0.3)$ keV. It is argued that the mass predicted by the QLL$\sigma$M corresponds to the $\gamma\gamma\to\sigma\to NN$ reaction, i.e. to a $t$-channel pole of the $\gamma N\to N\gamma$ reaction. Large -angle Compton scattering experiments revealing effects of the $\sigma$ meson in the differential cross section are discussed. Arguments are presented that these findings may be understood as an observation of the Higgs boson of strong interaction while being part of the constituent quark.Comment: 17 pages, 6 figure

Effect of lead acetate on Sertoli cell lactate production and protein synthesis in vitro

The effects of lead acetate on protein synthesis and lactate production by cultures of rat Sertoli cells in vitro were studied. Sertoli cell cultures prepared from 20 day old Sprague-Dawley rats were exposed to 0.01, 0.05 and 0.10 mM lead acetate. Lactate production was significantly elevated by all concentrations of lead after 3, 6, 9 and 12 hours of exposure. Protein biosynthesis as measured by [ 3 H]-leucine incorporation was significantly depressed by 0.05 and 0.10 mM lead acetate after 2 hours of exposure. These results support the hypothesis that lead acetate may inhibit spermatogenesis by a disturbance of the metabolic activities of the Sertoli cells.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/42549/1/10565_2004_Article_BF00122696.pd

Immunolocalization of ion-transport proteins to branchial epithelium mitochondria-rich cells in the mudskipper (Periophthalmodon schlosseri)

Journal of Experimental Biology203152297-2310JEBI

Fc gamma receptor-mediated influx of S100A8/A9-producing neutrophils as inducer of bone erosion during antigen-induced arthritis

Contains fulltext : 191403.pdf (publisher's version ) (Open Access

S100A8/A9 increases the mobilization of pro-inflammatory Ly6Chigh monocytes to the synovium during experimental osteoarthritis

Contains fulltext : 177935.pdf (publisher's version ) (Open Access)BACKGROUND: Monocytes are dominant cells present within the inflamed synovium during osteoarthritis (OA). In mice, two functionally distinct monocyte subsets are described: pro-inflammatory Ly6Chigh and patrolling Ly6Clow monocytes. Alarmins S100A8/A9 locally released by the synovium during inflammatory OA for prolonged periods may be dominant proteins involved in stimulating recruitment of Ly6Chigh monocytes from the circulation to the joint. Our objective was to investigate the role of S100A8/A9 in the mobilization of Ly6Chigh and Ly6Clow monocytic populations to the inflamed joint in collagenase-induced OA (CiOA). METHOD: S100A8 was injected intra-articularly to investigate monocyte influx. CiOA was induced by injection of collagenase into knee joints of wild-type C57BL/6 (WT), and S100a9-/- mice. Mice were sacrificed together with age-matched saline-injected control mice (n = 6/group), and expression of monocyte markers, pro-inflammatory cytokines, and chemokines was determined in the synovium using ELISA and RT-qPCR. Cells were isolated from the bone marrow (BM), spleen, blood, and synovium and monocytes were identified using FACS. RESULTS: S100A8/A9 was highly expressed during CiOA. Intra-articular injection of S100A8 leads to elevated expression of monocyte markers and the monocyte-attracting chemokines CCL2 and CX3CL1 in the synovium. At day 7 (d7) after CiOA induction in WT mice, numbers of Ly6Chigh, but not Ly6Clow monocytes, were strongly increased (7.6-fold) in the synovium compared to saline-injected controls. This coincided with strong upregulation of CCL2, which preferentially attracts Ly6Chigh monocytes. In contrast, S100a9-/- mice showed a significant increase in Ly6Clow monocytes (twofold) within the synovium at CiOA d7, whereas the number of Ly6Chigh monocytes remained unaffected. In agreement with this finding, the Ly6Clow mobilization marker CX3CL1 was significantly higher within the synovium of S100a9-/- mice. Next, we studied the effect of S100A8/A9 on release of Ly6Chigh monocytes from the BM into the circulation. A 14% decrease in myeloid cells was found in WT BM at CiOA d7. No decrease in myeloid cells in S100a9-/- BM was found, suggesting that S100A8/A9 promotes the release of myeloid populations from the BM. CONCLUSION: Induction of OA locally leads to strongly elevated S100A8/A9 expression and an elevated influx of Ly6Chigh monocytes from the BM to the synovium

Myeloid-related proteins S100A8/S100A9 regulate joint inflammation and cartilage destruction during antigen-induced arthritis.

OBJECTIVE: To study the active involvement of Myeloid-related proteins S100A8 and S100A9 in joint inflammation and cartilage destruction during antigen-induced arthritis (AIA). METHODS: Joint inflammation and cartilage destruction was measured with 99mTc uptake and histology. The role of S100A8/A9 was investigated by inducing AIA in S100A9-/- mice that also lack S100A8 at protein level, or after intra-articular injection of rS100A8 in mouse knee joints. Cartilage destruction was measured using immunolocalisation of the neoepitope VDIPEN or NITEGE. mRNA levels of matrix metalloproteinases (MMPs) and cytokines were measured using reverse transcriptase (RT)-PCR. RESULTS: Immunisation of S100A9-/- mice with the antigen mBSA induced normal cellular and humoral responses, not different from wild type (WT) controls. However, joint swelling measured at day 3 and 7 after AIA induction was significantly lower (36 and 70%, respectively). Histologically, at day 7 AIA, cellular mass was much lower (63-80%) and proteoglycan depletion from cartilage layers was significantly reduced (between 50-95%). Cartilage destruction mediated by MMPs was absent in S100A9-/- mice but clearly present in controls. MMP3, 9 and 13 mRNA levels were significantly lowered in arthritic synovia of S100A9-/-. In vitro stimulation of macrophages by the heterodimer S100A8/A9 or S100A8 elevated mRNA levels of MMP3, 9 and in particular MMP13. Intra-articular injection of S100A8 caused prominent joint inflammation and depletion of proteoglycans at day 1. Significant upregulation of mRNA levels of S100A8/A9, cytokines (interleukin 1 (IL1)), MMPs (MMP3, MMP13 and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)4) was found in the synovium and correlated with strong upregulation of NITEGE neoepitopes within the cartilage layers. CONCLUSIONS: S100A8/A9 regulate joint inflammation and cartilage destruction during antigen-induced arthritis