334 research outputs found
Author Correction:CRISPR-based transcriptional activation tool for silent genes in filamentous fungi (Scientific Reports, (2021), 11, 1, (1118), 10.1038/s41598-020-80864-3)
The Supplementary Information published with this Article contained errors. In Note S2, the text formatting including green italics, red bold, yellow underline, purple text and blue underline was omitted. The original Supplementary Information file is provided below. These errors have now been corrected in the Supplementary Information file that accompanies the original Article
Value of urinary N-methylhistamine measurements m childhood mastocytosis
Background: Histamine is an indicator of mast cell activation. N- methylhistamine (NMH) is a metabolite of histamine that can be measured in urine. Objective: Our purpose was to assess the usefulness of determining urinary NMH levels for the diagnosis and follow-up of patients with mastocytosis. Methods: Urinary NMH levels were determined in 44 patients and were correlated with disease activity and extension. The control group consisted of 24 children without mastocytosis or any other skin disease. Results: A significant negative correlation was found between NMH and age in patients with active mastocytosis and in the control group. Adjusted for age, NMH values were significantly higher in patients with active mastocytosis. There was a significant difference in NMH values between patients with diffuse cutaneous mastocytosis, patients with active urticaria pigmentosa, and patients with active mastocytomas. However, there was a substantial overlap of NMH values in the different subgroups. Conclusion: Urinary NMH values tend to decrease with age. Urinary NMH values correlated with the extent and the activity of the disease. High NMH values suggest more extensive involvement
Structure Functions of Unstable Lithium Isotopes
We study both the spin-average and spin-dependent structure functions of the
lithium isotopes, Li, which could be measured at RIKEN and other
nuclear facilities in the future. It is found that the light-cone momentum
distribution of the valence neutron in the halo of Li is very sharp and
symmetric around y = 1, because of the weak binding. The EMC ratios for Li
isotopes are then calculated. We study the possibility of extracting the
neutron structure function from data for the nuclear structure functions of the
Li isotopes. Next we calculate the spin-dependent structure functions of
Li isotopes, which have spin of 3/2. The effect of the nuclear
binding and Fermi motion on the multipole spin structure function,
, is about 10% in the region x < 0.7, but it becomes quite
important at large x. The spin structure function of is also
investigated. Finally, we discuss the modification of the Gottfried and Bjorken
integrals in a nuclear medium and point out several candidates for a pair of
mirror nuclei to study the flavor-nonsinglet quark distributions in nuclei.Comment: 23 pages + 7 tables + 15 figure
Optically opaque color-flavor locked phase inside compact stars
The contribution of thermally excited electron-positron pairs to the bulk
properties of the color-flavor locked quark phase inside compact stars is
examined. The presence of these pairs causes the photon mean free path to be
much smaller than a typical core radius ( km) for all
temperatures above 25 keV so that the photon contribution to the thermal
conductivity is much smaller than that of the Nambu-Goldstone bosons. We also
find that the electrons and positrons dominate the electrical conductivity,
while their contributions to the total thermal energy is negligible.Comment: 3 pages, 2 figures. Published versio
Neutron/Proton Structure Function Ratio at Large x
We re-examine the large-x neutron/proton structure function ratio extracted
from the latest deuteron data, taking into account the most recent developments
in the treatment of Fermi motion, binding and nucleon off-shell effects in the
deuteron. Our findings suggest that as x->1 the ratio of the neutron to proton
structure functions (F_2^n/F_2^p) is consistent with the perturbative QCD
expectation of 3/7, but larger than the value of 1/4 obtained in earlier
analyses.Comment: 18 pages RevTeX, 4 postscript figures, accepted for publication in
Phys. Lett.
Deep Inelastic Scattering from off-Shell Nucleons
We derive the general structure of the hadronic tensor required to describe
deep-inelastic scattering from an off-shell nucleon within a covariant
formalism. Of the large number of possible off-shell structure functions we
find that only three contribute in the Bjorken limit. In our approach the usual
ambiguities encountered when discussing problems related to off-shellness in
deep-inelastic scattering are not present. The formulation therefore provides a
clear framework within which one can discuss the various approximations and
assumptions which have been used in earlier work. As examples, we investigate
scattering from the deuteron, nuclear matter and dressed nucleons. The results
of the full calculation are compared with those where various aspects of the
off-shell structure are neglected, as well as with those of the convolution
model.Comment: 36 pages RevTeX, 9 figures (available upon request), ADP-93-210/T128,
PSI-PR-93-13, accepted for publication in Physical Review
Neurofibromatosis type 2 protein co-localizes with elements of the cytoskeleton
The product of the neurofibromatosis type 2 (NF2) tumor suppressor gene is a 595-amino-acid protein bearing resemblance to a family of band-4.1-related proteins. These proteins, including ezrin, radixin, and moesin, probably function as molecular linking proteins, connecting the cytoskeleton to the cell membrane. On the grounds of the homology to the ezrin, radixin, and moesin proteins and on the basis of its predicted secondary structure, the NF2 protein is also thought to act as a cytoskeleton-cell membrane linking protein. Using monoclonal antibodies to amino- and carboxyl-terminal synthetic NF2 peptides we demonstrate the co-localization of the NF2 protein with elements of the cytoskeleton in a COS cell model system and in cultured human cells. Furthermore, the presence of the NF2 protein in tissue sections is shown. The monoclonal antibodies specifically stain smooth muscle cells and the stratum granulosum of the human epidermis. In cultured smooth muscle cells the NF2 protein co-localizes with actin stress fibers. Immunoelectron microscopy demonstrates the presence of the NF2 protein associated with keratohyalin granules and to a lesser extent with intermediate filaments in the human epidermis. We conclude that the NF2 protein is indeed associated with multiple elements of the cytoskeleton.</p
Neurofibromatosis type 2 protein co-localizes with elements of the cytoskeleton
The product of the neurofibromatosis type 2 (NF2) tumor suppressor gene is a 595-amino-acid protein bearing resemblance to a family of band-4.1-related proteins. These proteins, including ezrin, radixin, and moesin, probably function as molecular linking proteins, connecting the cytoskeleton to the cell membrane. On the grounds of the homology to the ezrin, radixin, and moesin proteins and on the basis of its predicted secondary structure, the NF2 protein is also thought to act as a cytoskeleton-cell membrane linking protein. Using monoclonal antibodies to amino- and carboxyl-terminal synthetic NF2 peptides we demonstrate the co-localization of the NF2 protein with elements of the cytoskeleton in a COS cell model system and in cultured human cells. Furthermore, the presence of the NF2 protein in tissue sections is shown. The monoclonal antibodies specifically stain smooth muscle cells and the stratum granulosum of the human epidermis. In cultured smooth muscle cells the NF2 protein co-localizes with actin stress fibers. Immunoelectron microscopy demonstrates the presence of the NF2 protein associated with keratohyalin granules and to a lesser extent with intermediate filaments in the human epidermis. We conclude that the NF2 protein is indeed associated with multiple elements of the cytoskeleton.</p
Autoimmune lymphoproliferative syndrome (ALPS) in a child from consanguineous parents: a dominant or recessive disease?
Autoimmune lymphoproliferative syndrome (ALPS) is characterized by
autoimmune features and lymphoproliferations and is generally caused by
defective Fas-mediated apoptosis. This report describes a child with
clinical features of ALPS without detectable Fas expression on freshly
isolated blood leukocytes. Detection of FAS transcripts via real-time
quantitative PCR made a severe transcriptional defect unlikely. Sequencing
of the FAS gene revealed a 20-nucleotide duplication in the last exon
affecting the cytoplasmic signaling domain. The patient was homozygous for
this mutation, whereas the consanguineous parents and the siblings were
heterozygous. The patient reported here is a human homologue of the
Fas-null mouse, inasmuch as she carries an autosomal homozygous mutation
in the FAS gene and she shows the severe and accelerated ALPS phenotype.
The heterozygous family members did not have the ALPS phenotype,
indicating that the disease-causing FAS mutation in this family is
autosomal recessive
Hamiltonian approach to the ac Josephson effect in superconducting-normal hybrid systems
The ac Josephson effect in hybrid systems of a normal mesoscopic conductor
coupled to two superconducting (S) leads is investigated theoretically. A
general formula of the ac components of time-dependent current is derived which
is valid for arbitrary interactions in the normal region. We apply this formula
to analyze a S-normal-S system where the normal region is a noninteracting
single level quantum dot. We report the physical behavior of time-averaged
nonequilibrium distribution of electrons in the quantum dot, the formation of
Andreev bound states, and ac components of the time-dependent current. The
distribution is found to exhibit a population inversion; and all Andreev bound
states between the superconducting gap carry the same amount of
current and in the same flow direction. The ac components of time-dependent
current show strong oscillatory behavior in marked contrast to the subharmonic
gap structure of the average current.Comment: 23 pages, 10 figures, LaTe
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