50 research outputs found
Role of shear stress in endothelial cell morphology and expression of cyclooxygenase isoforms
MEDLINE® is the source for the MeSH terms of this document.Objective-: The goal of this study was to examine the effect of chronic heterogeneous shear stress, applied using an orbital shaker, on endothelial cell morphology and the expression of cyclooxygenases 1 and 2. Methods and results-: Porcine aortic endothelial cells were plated on fibronectin-coated Transwell plates. Cells were cultured for up to 7 days either under static conditions or on an orbital shaker that generated a wave of medium inducing shear stress over the cells. Cells were fixed and stained for the endothelial surface marker CD31 or cyclooxygenases 1 and 2. En face confocal microscopy and scanning ion conductance microscopy were used to show that endothelial cells were randomly oriented at the center of the well, aligned with shear stress nearer the periphery, and expressed cyclooxygenase-1 under all conditions. Lipopolysaccharide induced cyclooxygenase-2 and the production of 6-keto-prostaglandin F1α in all cells. Conclusion-: Cyclooxygenase-1 is expressed in endothelial cells cultured under chronic shear stress of high or low directionality.Peer reviewedSubmitted Versio
Nanomechanics of a magnetic shuttle device
We show that self sustained mechanical vibrations in a model magnetic shuttle device can be driven by both
the charge and the spin accumulated on the movable central island of the device. Different scenarios for how
spin- and charge-induced shuttle instabilities may develop are discussed and shown to depend on whether there
is a Coulomb blockade of tunneling or not. The crucial role of electronic spin flips in a magnetically driven shuttle
is established and shown to cause giant magnetoresistance and dynamic magnetostriction effects
Small-Size Resonant Photoacoustic Cell of Inclined Geometry for Gas Detection
A photoacoustic cell intended for laser detection of trace gases is
represented. The cell is adapted so as to enhance the gas-detection performance
and, simultaneously, to reduce the cell size. The cell design provides an
efficient cancellation of the window background (a parasite response due to
absorption of laser beam in the cell windows) and acoustic isolation from the
environment for an acoustic resonance of the cell. The useful photoacoustic
response from a detected gas, window background and noise are analyzed in
demonstration experiments as functions of the modulation frequency for a
prototype cell with the internal volume ~ 0.5 cm^3. The minimal detectable
absorption for the prototype is estimated to be ~ 1.2 10^{-8} cm^{-1} W
Hz^{-1/2}.Comment: 11 pages, 5 figure
Electronic spin working mechanically (Review Article)
A single-electron tunneling (SET) device with a nanoscale central island that can move with respect to the
bulk source- and drain electrodes allows for a nanoelectromechanical (NEM) coupling between the electrical
current through the device and mechanical vibrations of the island. Although an electromechanical “shuttle” instability
and the associated phenomenon of single-electron shuttling were predicted more than 15 years ago, both
theoretical and experimental studies of NEM-SET structures are still carried out. New functionalities based on
quantum coherence, Coulomb correlations and coherent electron-spin dynamics are of particular current interest.
In this article we present a short review of recent activities in this area
Carbon Nanotubes as Nanoelectromechanical Systems
We theoretically study the interplay between electrical and mechanical
properties of suspended, doubly clamped carbon nanotubes in which charging
effects dominate. In this geometry, the capacitance between the nanotube and
the gate(s) depends on the distance between them. This dependence modifies the
usual Coulomb models and we show that it needs to be incorporated to capture
the physics of the problem correctly. We find that the tube position changes in
discrete steps every time an electron tunnels onto it. Edges of Coulomb
diamonds acquire a (small) curvature. We also show that bistability in the tube
position occurs and that tunneling of an electron onto the tube drastically
modifies the quantized eigenmodes of the tube. Experimental verification of
these predictions is possible in suspended tubes of sub-micron length.Comment: 8 pages, 5 eps figures included. Major changes; new material adde
Nonequilibrium Josephson effect in mesoscopic ballistic multiterminal SNS junctions
We present a detailed study of nonequilibrium Josephson currents and
conductance in ballistic multiterminal SNS-devices. Nonequilibrium is created
by means of quasiparticle injection from a normal reservoir connected to the
normal part of the junction. By applying a voltage at the normal reservoir the
Josephson current can be suppressed or the direction of the current can be
reversed. For a junction longer than the thermal length, , the
nonequilibrium current increases linearly with applied voltage, saturating at a
value equal to the equilibrium current of a short junction. The conductance
exhibits a finite bias anomaly around . For symmetric
injection, the conductance oscillates -periodically with the phase
difference between the superconductors, with position of the minimum
( or ) dependent on applied voltage and temperature. For
asymmetric injection, both the nonequilibrium Josephson current and the
conductance becomes -periodic in phase difference. Inclusion of barriers
at the NS-interfaces gives rise to a resonant behavior of the total Josephson
current with respect to junction length with a period . Both
three and four terminal junctions are studied.Comment: 21 pages, 19 figures, submitted to Phys. Rev.
1H and 13C NMR Study of Tautomerism of 9-Hydroxy-3-methylphenalen-1-ones
Tautomeric equilibria in the series of substituted 9-hydroxy-3-melhylphenalen-1-ones involve proton transfer from the hydroxy to the carbonyl group. The state of the equilibria is determined by the position of the methoxy groups. The relations between the heats of formation of tautomers, calculated by the AMI method, are consistent with the 1H and 13C NMR data