9 research outputs found
Metformin use may moderate the effect of DPP-4 inhibitors on cardiovascular outcomes
Objective: To explore prevalent metformin use as a potential moderator of the cardiovascular effects of dipeptidyl peptidase 4 inhibitors (DPP-4i). Research Design and Methods: We performed a meta-analysis of the three major cardiovascular outcomes trials examining DPP-4i. We used meta-regression to examine how the cardiovascular effects of DPP-4i differ between prevalent metformin users and baseline nonusers. Results: While prevalent metformin users experienced a trend toward improved cardiovascular outcomes with DPP-4i (summary hazard ratio [HR] 0.92 [95% CI 0.84, 1.01]), baseline metformin nonusers showed a trend toward harm(HR 1.10 [95% CI 0.97, 1.26]). The difference in overall DPP-4i effect between metformin user and nonuser subgroups was statistically significant (P = 0.036). Conclusions: Baseline metformin status may have a moderating effect on cardiovascular outcomes with DPP-4i use. This hypothesis-generating analysis suggests there is residual uncertainty as to how DPP-4i affect cardiovascular outcomes, depending on concurrently prescribed medications
A Path Integral Approach To Noncommutative Superspace
A path integral formula for the associative star-product of two superfields
is proposed. It is a generalization of the Kontsevich-Cattaneo-Felder's formula
for the star-product of functions of bosonic coordinates. The associativity of
the star-product imposes certain conditions on the background of our sigma
model. For generic background the action is not supersymmetric. The
supersymmetry invariance of the action constrains the background and leads to a
simple formula for the star-product.Comment: Latex 13 pages. v2: references and footnotes adde
Effect of the CT Table Strap on Radiation Exposure and Image Quality during Cervical Spine CT
Quality of life and cost-effectiveness of acupuncture treatment in patients with osteoarthritis pain
Cost-effectiveness, Acupuncture, Routine care, Randomised controlled trial, Osteoarthritis pain,
Family therapy and the notion of accountability: With reference to trends in individual psychotherapy
Improving vasomotor symptoms; psychological symptoms; and health-related quality of life in peri- or post-menopausal women through yoga: An umbrella systematic review and meta-analysis
ObjectivesVasomotor symptoms (VMS), commonly reported during menopausal transition, negatively affect psychological health and health-related quality of life (HRQoL). While hormone therapy is an effective treatment, its use is limited by concerns about possible harms. Thus, many women with VMS seek nonhormonal, nonpharmacologic treatment options. However, evidence to guide clinical recommendations is inconclusive. This study reviewed the effectiveness of yoga, tai chi and qigong on vasomotor, psychological symptoms, and HRQoL in peri- or post-menopausal women.DesignMEDLINE, Cochrane Database of Systematic Reviews, EMBASE, CINAHL and the Allied and Complementary Medicine Database were searched. Researchers identified systematic reviews (SR) or RCTs that evaluated yoga, tai chi, or qigong for vasomotor, psychological symptoms, and health-related quality of life (HRQoL) in peri- or post-menopausal women. Data were abstracted on study design, participants, interventions and outcomes. Risk of bias (ROB) was assessed and updated meta-analyses were performed.ResultsWe identified one high-quality SR (5 RCTs, 582 participants) and 3 new RCTs (345 participants) published after the SR evaluating yoga for vasomotor, psychological symptoms, and HRQoL; no studies evaluated tai chi or qigong. Updated meta-analyses indicate that, compared to controls, yoga reduced VMS (5 trials, standardized mean difference (SMD) -0.27, 95% CI -0.49 to -0.05) and psychological symptoms (6 trials, SDM -0.32; 95% CI -0.47 to -0.17). Effects on quality of life were reported infrequently. Key limitations are that adverse effects were rarely reported and outcome measures lacked standardization.ConclusionsResults from this meta-analysis suggest that yoga may be a useful therapy to manage bothersome vasomotor and psychological symptoms