Echocariographic correlation of cardiac function in patients of hypothyroidism

Objective: The aim of the current study was to identify the echocardiographic changes in patients with hypothyroidism and correlation of these echocardiographic changes with the severity of hypothyroidism. Method: A cross-sectional, and observational study was conducted on 60 treatment naïve patients of 18 to 60 years with hypothyroidism for 15 months from March 2021 to July 2022. The clinical demographic, treatment, ECG and echocardiographic profile were assessed in all patients. The association between categorical findings was determined using the chi-square test. Percentages and frequencies were also used for every parameter. Results: 36.6% of the patients belonged to the age group 31 to 40 years. The mean age was 37.2±10.67 years and the majority of patients were females (76.67%). 33.3% of patients were overweight. 21.67% were obese and 45% had normal BMI. 21.67% had mild hypothyroidism, 56.67% had subclinical and 8.33% had severe hypothyroidism. There was a significant association between BMI and severity of hypothyroidism (p=0.0167). Abnormal lipid profile was seen in 61.67% of patients and a significant association was observed between total cholesterol and the severity of hypothyroidism (p=0.0031). LVPW thickness was normal in 78.33% of patients. Abnormal interventricular septal thickness was seen in 28.33% of patients. The cardiac chamber was more than 5.4cm in 3.33% of patients. Pericardial effusion was observed in 12 patients. There was a significant association between LVPW thickness, interseptal thickness, cardiac chamber size, ejection fraction, E/A ratio, and severity of hypothyroidism. Conclusion: Increased interventricular septal and left ventricular posterior wall thicknesses with diastolic dysfunction are one of the earliest heart changes noted in patients with hypothyroidism. Early diagnosis in patients with hypothyroidism will definitely reduce the extent of cardiac complications that accompany it. ECG and echocardiography are useful noninvasive tools in assessing the response to thyroid replacement therapy. The study suggests screening of all patients with hypothyroidism using electrocardiography and ECG as most of the patients show impairment in cardiac functions, so that appropriate intervention can be taken earlier

Linking Distributive and Procedural Justice to Employee Engagement Through Social Exchange: A Field Study in India

Research linking justice perceptions to employee outcomes has referred to social exchange as its central theoretical premise. We tested a conceptual model linking distributive and procedural justice to employee engagement through social exchange mediators, namely, perceived organizational support and psychological contract, among 238 managers and executives from manufacturing and service sector firms in India. Findings suggest that perceived organizational support mediated the relationship between distributive justice and employee engagement, and both perceived organizational support and psychological contract mediated the relationship between procedural justice and employee engagement. Theoretical and practical implications with respect to organizational functions are discussed

First Measurement of the Nuclear-Recoil Ionization Yield in Silicon at 100 eV

We measured the nuclear-recoil ionization yield in silicon with a cryogenic phonon-sensitive gram-scale detector. Neutrons from a monoenergetic beam scatter off of the silicon nuclei at angles corresponding to energy depositions from 4 keV down to 100 eV, the lowest energy probed so far. The results show no sign of an ionization production threshold above 100 eV. These results call for further investigation of the ionization yield theory and a comprehensive determination of the detector response function at energies below the keV scale

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-w (IFN-w) (13 patients), against the 13 types of IFN-a (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men

Search for intermediate mass black hole binaries in the first and second observing runs of the Advanced LIGO and Virgo network

Gravitational-wave astronomy has been firmly established with the detection of gravitational waves from the merger of ten stellar-mass binary black holes and a neutron star binary. This paper reports on the all-sky search for gravitational waves from intermediate mass black hole binaries in the first and second observing runs of the Advanced LIGO and Virgo network. The search uses three independent algorithms: two based on matched filtering of the data with waveform templates of gravitational-wave signals from compact binaries, and a third, model-independent algorithm that employs no signal model for the incoming signal. No intermediate mass black hole binary event is detected in this search. Consequently, we place upper limits on the merger rate density for a family of intermediate mass black hole binaries. In particular, we choose sources with total masses M=m1+m2ϵ[120,800] M and mass ratios q=m2/m1ϵ[0.1,1.0]. For the first time, this calculation is done using numerical relativity waveforms (which include higher modes) as models of the real emitted signal. We place a most stringent upper limit of 0.20 Gpc-3 yr-1 (in comoving units at the 90% confidence level) for equal-mass binaries with individual masses m1,2=100 M and dimensionless spins χ1,2=0.8 aligned with the orbital angular momentum of the binary. This improves by a factor of ∼5 that reported after Advanced LIGO's first observing run. © 2019 American Physical Society

Search for gravitational waves from Scorpius X-1 in the second Advanced LIGO observing run with an improved hidden Markov model

We present results from a semicoherent search for continuous gravitational waves from the low-mass x-ray binary Scorpius X-1, using a hidden Markov model (HMM) to track spin wandering. This search improves on previous HMM-based searches of LIGO data by using an improved frequency domain matched filter, the J-statistic, and by analyzing data from Advanced LIGO's second observing run. In the frequency range searched, from 60 to 650 Hz, we find no evidence of gravitational radiation. At 194.6 Hz, the most sensitive search frequency, we report an upper limit on gravitational wave strain (at 95% confidence) of h095%=3.47×10-25 when marginalizing over source inclination angle. This is the most sensitive search for Scorpius X-1, to date, that is specifically designed to be robust in the presence of spin wandering. © 2019 American Physical Society

Narrow-band search for gravitational waves from known pulsars using the second LIGO observing run

Isolated spinning neutron stars, asymmetric with respect to their rotation axis, are expected to be sources of continuous gravitational waves. The most sensitive searches for these sources are based on accurate matched filtering techniques that assume the continuous wave to be phase locked with the pulsar beamed emission. While matched filtering maximizes the search sensitivity, a significant signal-to-noise ratio loss will happen in the case of a mismatch between the assumed and the true signal phase evolution. Narrow-band algorithms allow for a small mismatch in the frequency and spin-down values of the pulsar while coherently integrating the entire dataset. In this paper, we describe a narrow-band search using LIGO O2 data for the continuous wave emission of 33 pulsars. No evidence of a continuous wave signal is found, and upper limits on the gravitational wave amplitude over the analyzed frequency and spin-down ranges are computed for each of the targets. In this search, we surpass the spin-down limit, namely, the maximum rotational energy loss due to gravitational waves emission for some of the pulsars already present in the LIGO O1 narrow-band search, such as J1400-6325, J1813-1246, J1833-1034, J1952+3252, and for new targets such as J0940-5428 and J1747-2809. For J1400-6325, J1833-1034, and J1747-2809, this is the first time the spin-down limit is surpassed. © 2019 American Physical Society

Erratum: "A Gravitational-wave Measurement of the Hubble Constant Following the Second Observing Run of Advanced LIGO and Virgo" (2021, ApJ, 909, 218)

[no abstract available