Fatigue response evaluation of stainless steel SS 304 L(N) and SS 316 L(N) through cyclic ball indentation studies

This paper presents the results of an experimental investigation of fatigue response of stainless steel SS 304 L(N) and SS 316 L(N) using cyclic ball indentation test method. A Tungsten Carbide (WC) spherical ball of 1.57 mm diameter is used for applying compression-compression fatigue cycling on the test specimen having a nominal thickness of 5 mm; the displacement response is monitored as a function of every cycle of loading. The study focused on cases where the stainless steel specimens were welded by two different welding processes – Activated flux TIG welding and conventional multi-pass TIG welding. Fatigue response was monitored at locations of weld zone, heat affected zone (HAZ) and base metal to identify the effect of microstructure variation on fatigue response. It is observed that there is a steady increase in depth of penetration of the spherical indenter due to fatigue cycling; however, after a number of cycles, there is a sudden increase in depth of penetration which indicates the failure of the material beneath the indenter. The specimens after cyclic ball indentation were examined using a scanning electron microscope and one could observe the presence of secondary cracking in the penetrated region of the specimen

Strange hadron matter and SU(3) symmetry

We calculate saturation curves for strange hadron matter using recently constructed baryon-baryon potentials which are constrained by SU(3) symmetry. All possible interaction channels within the baryon octet (consisting of $N$, $\Lambda$, $\Sigma$, and $\Xi$) are considered. It is found that a small $\Lambda$ fraction in nuclear matter slightly increases binding, but that larger fractions ($>10$) rapidly cause a decrease. Charge-neutral ${N,\Lambda,\Xi}$ systems, with equal densities for nucleons and cascades, are only very weakly bound. The dependence of the binding energies on the strangeness per baryon, $f_s$, is predicted for various ${N,\Lambda,\Xi}$ and ${N,\Lambda,\Sigma,\Xi}$ systems. The implications of our results in relativistic heavy-ion collisions and the core of a dense star are discussed. We also discuss the differences between our results and previous hadron matter calculations.Comment: 14 pages RevTeX, 7 postscript figure

Soft-core baryon-baryon potentials for the complete baryon octet

SU(3) symmetry relations on the recently constructed hyperon-nucleon potentials are used to develop potential models for all possible baryon-baryon interaction channels. The main focus is on the interaction channels with total strangeness S=-2, -3, and -4, for which no experimental data exist yet. The potential models for these channels are based on SU(3) extensions of potential models for the S=0 and S=-1 sectors, which are fitted to experimental data. Although the SU(3) symmetry is not taken to be exact, the S=0 and S=-1 sectors still provide the necessary constraints to fix all free parameters. The potentials for the S=-2, -3, and -4 sectors, therefore, do not contain any additional free parameters, which makes them the first models of this kind. Various properties of the potentials are illustrated by giving results for scattering lengths, bound states, and total cross sections.Comment: 22 pages RevTex, 6 postscript figure

Warm stellar matter with deconfinement: application to compact stars

We investigate the properties of mixed stars formed by hadronic and quark matter in $\beta$-equilibrium described by appropriate equations of state (EOS) in the framework of relativistic mean-field theory. We use the non- linear Walecka model for the hadron matter and the MIT Bag and the Nambu-Jona-Lasinio models for the quark matter. The phase transition to a deconfined quark phase is investigated. In particular, we study the dependence of the onset of a mixed phase and a pure quark phase on the hyperon couplings, quark model and properties of the hadronic model. We calculate the strangeness fraction with baryonic density for the different EOS. With the NJL model the strangeness content in the mixed phase decreases. The calculations were performed for T=0 and for finite temperatures in order to describe neutron and proto-neutron stars. The star properties are discussed. Both the Bag model and the NJL model predict a mixed phase in the interior of the star. Maximum allowed masses for proto-neutron stars are larger for the NJL model ($\sim 1.9$ M$_{\bigodot}$) than for the Bag model ($\sim 1.6$ M$_{\bigodot}$).Comment: RevTeX,14 figures, accepted to publication in Physical Review

Neutron star properties in the quark-meson coupling model

The effects of internal quark structure of baryons on the composition and structure of neutron star matter with hyperons are investigated in the quark-meson coupling (QMC) model. The QMC model is based on mean-field description of nonoverlapping spherical bags bound by self-consistent exchange of scalar and vector mesons. The predictions of this model are compared with quantum hadrodynamic (QHD) model calibrated to reproduce identical nuclear matter saturation properties. By employing a density dependent bag constant through direct coupling to the scalar field, the QMC model is found to exhibit identical properties as QHD near saturation density. Furthermore, this modified QMC model provides well-behaved and continuous solutions at high densities relevant to the core of neutron stars. Two additional strange mesons are introduced which couple only to the strange quark in the QMC model and to the hyperons in the QHD model. The constitution and structure of stars with hyperons in the QMC and QHD models reveal interesting differences. This suggests the importance of quark structure effects in the baryons at high densities.Comment: 28 pages, 10 figures, to appear in Physical Review

Asymmetric nuclear matter:the role of the isovector scalar channel

We try to single out some qualitative new effects of the coupling to the $\delta$-isovector-scalar meson introduced in a minimal way in a phenomenological hadronic field theory. Results for the equation of state ($EOS$) and the phase diagram of asymmetric nuclear matter ($ANM$) are discussed. We stress the consistency of the $\delta$-coupling introduction in a relativistic approach. New contributions to the slope and curvature of the symmetry energy and the neutron-proton effective mass splitting appear particularly interesting. A more repulsive $EOS$ for neutron matter at high baryon densities is expected. Effects on new critical properties of warm $ANM$, mixing of mechanical and chemical instabilities and isospin distillation, are also presented. The $\delta$ influence is mostly on the {\it isovectorlike} collective response. The results are largely analytical and this makes the physical meaning quite transparent. Implications for nuclear structure properties of drip-line nuclei and for reaction dynamics with Radioactive Beams are finally pointed out.Comment: 12 pages, 10 Postscript figure

Small, Dense Quark Stars from Perturbative QCD

As a model for nonideal behavior in the equation of state of QCD at high density, we consider cold quark matter in perturbation theory. To second order in the strong coupling constant, $\alpha_s$, the results depend sensitively on the choice of the renormalization mass scale. Certain choices of this scale correspond to a strongly first order chiral transition, and generate quark stars with maximum masses and radii approximately half that of ordinary neutron stars. At the center of these stars, quarks are essentially massless.Comment: ReVTeX, 5 pages, 3 figure

Antikaon condensation and the metastability of protoneutron stars

We investigate the condensation of $\bar K^0$ meson along with $K^-$ condensation in the neutrino trapped matter with and without hyperons. Calculations are performed in the relativistic mean field models in which both the baryon-baryon and (anti)kaon-baryon interactions are mediated by meson exchange. In the neutrino trapped matter relevant to protoneutron stars, the critical density of $K^-$ condensation is shifted considerably to higher density whereas that of $\bar K^0$ condensation is shifted slightly to higher density with respect to that of the neutrino free case. The onset of $K^-$ condensation always occurs earlier than that of $\bar K^0$ condensation. A significant region of maximum mass protoneutron stars is found to contain $\bar K^0$ condensate for larger values of the antikaon potential. With the appearance of $\bar K^0$ condensation, there is a region of symmetric nuclear matter in the inner core of a protoneutron star. It is found that the maximum mass of a protoneutron star containing $K^-$ and $\bar K^0$ condensate is greater than that of the corresponding neutron star. We revisit the implication of this scenario in the context of the metastability of protoneutron stars and their evolution to low mass black holes.Comment: 26 pages; Revtex; 8 figures include

Designing a broad-spectrum integrative approach for cancer prevention and treatment

Targeted therapies and the consequent adoption of "personalized" oncology have achieved notablesuccesses in some cancers; however, significant problems remain with this approach. Many targetedtherapies are highly toxic, costs are extremely high, and most patients experience relapse after a fewdisease-free months. Relapses arise from genetic heterogeneity in tumors, which harbor therapy-resistantimmortalized cells that have adopted alternate and compensatory pathways (i.e., pathways that are notreliant upon the same mechanisms as those which have been targeted). To address these limitations, aninternational task force of 180 scientists was assembled to explore the concept of a low-toxicity "broad-spectrum" therapeutic approach that could simultaneously target many key pathways and mechanisms. Using cancer hallmark phenotypes and the tumor microenvironment to account for the various aspectsof relevant cancer biology, interdisciplinary teams reviewed each hallmark area and nominated a widerange of high-priority targets (74 in total) that could be modified to improve patient outcomes. For thesetargets, corresponding low-toxicity therapeutic approaches were then suggested, many of which werephytochemicals. Proposed actions on each target and all of the approaches were further reviewed forknown effects on other hallmark areas and the tumor microenvironment. Potential contrary or procar-cinogenic effects were found for 3.9% of the relationships between targets and hallmarks, and mixedevidence of complementary and contrary relationships was found for 7.1%. Approximately 67% of therelationships revealed potentially complementary effects, and the remainder had no known relationship. Among the approaches, 1.1% had contrary, 2.8% had mixed and 62.1% had complementary relationships. These results suggest that a broad-spectrum approach should be feasible from a safety standpoint. Thisnovel approach has potential to be relatively inexpensive, it should help us address stages and types ofcancer that lack conventional treatment, and it may reduce relapse risks. A proposed agenda for futureresearch is offered

The Public Repository of Xenografts enables discovery and randomized phase II-like trials in mice

More than 90% of drugs with preclinical activity fail in human trials, largely due to insufficient efficacy. We hypothesized that adequately powered trials of patient-derived xenografts (PDX) in mice could efficiently define therapeutic activity across heterogeneous tumors. To address this hypothesis, we established a large, publicly available repository of well-characterized leukemia and lymphoma PDXs that undergo orthotopic engraftment, called the Public Repository of Xenografts (PRoXe). PRoXe includes all de-identified information relevant to the primary specimens and the PDXs derived from them. Using this repository, we demonstrate that large studies of acute leukemia PDXs that mimic human randomized clinical trials can characterize drug efficacy and generate transcriptional, functional, and proteomic biomarkers in both treatment-naive and relapsed/refractory disease