Book Review: Time and Its Adversaries in the Seleucid Empire by Paul Kosmin

Book review by Joseph A. P. Wilson. Kosmin, P. J. (2018). Time and Its adversaries in the Seleucid Empire. Cambridge, MA: Harvard University Press

Characterization, cloning and immunogenicity of antigens released by transforming cercariae of Schistosoma mansoni

A schistosome infection is initiated when the parasite penetrates the skin of a susceptible host. Relatively large quantities of protein are released by transforming cercariae compared to later larval stages. This represents the first parasite material to which the host's immune system is exposed, yet little is known about the proteins which are released during the first few hours post-transformation. We have shown that antiserum raised against such molecules was capable of imparting protection against a schistosome challenge infection upon passive transfer to naïve mice. By screening a cercarial cDNA library with this serum, 38 positive clones were identified. Sequence analysis showed these to represent 8 different molecules which included Schistosoma mansoni 21·7 kDa antigen, calcium-binding-protein and the vaccine candidate glutathione S-transferase (Sm28GST). In addition, 5 clones were isolated, 1 of which had significant homology to many cytochrome C proteins, another with leukocyte elastase inhibitors and 3 which represented novel molecules. Four clones were expressed in a prokaryotic high-level expression vector, sera produced against each purified recombinant protein and used subsequently to probe Western blots and parasite sections. The leukocyte elastase inhibitor homologue and 2 unknowns induced significant proliferation by lymph node cells recovered from mice vaccinated with irradiated cercariae. More strikingly, the 2 novel proteins stimulated very high levels of interferon [gamma] (IFN[gamma]) secretion both by lymph node cells and those recovered by broncho-alveolar lavage from the lungs of vaccinated mice. Such results will be discussed in the context of vaccine development

ENERGY ACQUISITION AND ALLOCATION IN PLANTS AND INSECTS: A HYPOTHESIS FOR THE POSSIBLE ROLE OF HORMONES IN INSECT FEEDING PATTERNS

A distributed delay age structure model is presented for plants and insects that describes the dynamics of per capita energy (dry matter) acquisition and allocation patterns, and the within-organism subunit (e.g. leaves, fruit, ova) number dynamics that occur during growth, reproduction, and development. Four species of plants (common bean, cassava, cotton, and tomato) and two species of insects (pea aphid and a ladybird beetle) are modeled. A common acquisition (i.e. functional response) submodel is used to estimate the daily photosynthetic rates in plants and consumption rates in pea aphid and the ladybird beetle. The focus of this work is to capture the essence of the common attributes between trophic levels across this wide range of taxa. The models are compared with field or laboratory data. A hypothesis is proposed for the observed patterns of reproduction in pea aphid and in a ladybird beetl

Spontaneous chiral symmetry breaking in the linked cluster expansion

We investigate dynamical chiral symmetry breaking in the Coulomb gauge Hamiltonian QCD. Within the framework of the linked cluster expansion we extend the BCS ansatz for the vacuum and include correlation beyond the quark-antiquark paring. In particular we study the effects of the three-body correlations involving quark-antiquark and transverse gluons. The high momentum behavior of the resulting gap equation is discussed and numerical computation of the chiral symmetry breaking is presented.Comment: 13 pages, 9 figure

Special relativity constraints on the effective constituent theory of hybrids

We consider a simplified constituent model for relativistic strong-interaction decays of hybrid mesons. The model is constructed using rules of renormalization group procedure for effective particles in light-front quantum field theory, which enables us to introduce low-energy phenomenological parameters. Boost covariance is kinematical and special relativity constraints are reduced to the requirements of rotational symmetry. For a hybrid meson decaying into two mesons through dissociation of a constituent gluon into a quark-anti-quark pair, the simplified constituent model leads to a rotationally symmetric decay amplitude if the hybrid meson state is made of a constituent gluon and a quark-anti-quark pair of size several times smaller than the distance between the gluon and the pair, as if the pair originated from one gluon in a gluonium state in the same effective theory.Comment: 11 pages, 5 figure

Characterizing the metabolic effects of the selective inhibition of gut microbial β-glucuronidases in mice

The hydrolysis of xenobiotic glucuronides by gut bacterial glucuronidases reactivates previously detoxified compounds resulting in severe gut toxicity for the host. Selective bacterial β-glucuronidase inhibitors can mitigate this toxicity but their impact on wider host metabolic processes has not been studied. To investigate this the inhibitor 4-(8-(piperazin-1-yl)-1,2,3,4-tetrahydro-[1,2,3]triazino[4′,5′:4,5]thieno[2,3-c]isoquinolin-5-yl)morpholine (UNC10201652, Inh 9) was administered to mice to selectively inhibit a narrow range of bacterial β-glucuronidases in the gut. The metabolomic profiles of the intestinal contents, biofluids, and several tissues involved in the enterohepatic circulation were measured and compared to control animals. No biochemical perturbations were observed in the plasma, liver or gall bladder. In contrast, the metabolite profiles of urine, colon contents, feces and gut wall were altered compared to the controls. Changes were largely restricted to compounds derived from gut microbial metabolism. This work establishes that inhibitors targeted towards bacterial β-glucuronidases modulate the functionality of the intestinal microbiota without adversely impacting the host metabolic system

Bispectral KP Solutions and Linearization of Calogero-Moser Particle Systems

A new construction using finite dimensional dual grassmannians is developed to study rational and soliton solutions of the KP hierarchy. In the rational case, properties of the tau function which are equivalent to bispectrality of the associated wave function are identified. In particular, it is shown that there exists a bound on the degree of all time variables in tau if and only if the wave function is rank one and bispectral. The action of the bispectral involution, beta, in the generic rational case is determined explicitly in terms of dual grassmannian parameters. Using the correspondence between rational solutions and particle systems, it is demonstrated that beta is a linearizing map of the Calogero-Moser particle system and is essentially the map sigma introduced by Airault, McKean and Moser in 1977.Comment: LaTeX, 24 page

Critical behavior of the planar magnet model in three dimensions

We use a hybrid Monte Carlo algorithm in which a single-cluster update is combined with the over-relaxation and Metropolis spin re-orientation algorithm. Periodic boundary conditions were applied in all directions. We have calculated the fourth-order cumulant in finite size lattices using the single-histogram re-weighting method. Using finite-size scaling theory, we obtained the critical temperature which is very different from that of the usual XY model. At the critical temperature, we calculated the susceptibility and the magnetization on lattices of size up to $42^3$. Using finite-size scaling theory we accurately determine the critical exponents of the model and find that $\nu$=0.670(7), $\gamma/\nu$=1.9696(37), and $\beta/\nu$=0.515(2). Thus, we conclude that the model belongs to the same universality class with the XY model, as expected.Comment: 11 pages, 5 figure

Gas chromatography-mass spectrometry analysis of irradiated fluoxetine aqueous samples

The last decade witnessed the drastic increase in the use of antidepressant drugs, being fluoxetine the most prescribed worldwide. Conventional wastewater treatment is inefficient in removing fluoxetine and its accumulation in water bodies and water living organism is inevitable. Among several methods for contaminant removal from wastewater, electron beam irradiation is an efficient and green technology. This work presents the characterization of aqueous fluoxetine samples before and after irradiation. Gas chromatography coupled to mass spectrometry was used to identify the original compound and its irradiation products. Results indicate a drastic reduction in fluoxetine presence after the irradiation process. Radiolysis pathways were proposed based on mass fragments identification