Changing trends in mortality among solid organ transplant recipients hospitalized for COVID-19 during the course of the pandemic

Mortality among patients hospitalized for COVID-19 has declined over the course of the pandemic. Mortality trends specifically in solid organ transplant recipients (SOTR) are unknown. Using data from a multicenter registry of SOTR hospitalized for COVID-19, we compared 28-day mortality between early 2020 (March 1, 2020–June 19, 2020) and late 2020 (June 20, 2020–December 31, 2020). Multivariable logistic regression was used to assess comorbidity-adjusted mortality. Time period of diagnosis was available for 1435/1616 (88.8%) SOTR and 971/1435 (67.7%) were hospitalized: 571/753 (75.8%) in early 2020 and 402/682 (58.9%) in late 2020 (p <.001). Crude 28-day mortality decreased between the early and late periods (112/571 [19.6%] vs. 55/402 [13.7%]) and remained lower in the late period even after adjusting for baseline comorbidities (aOR 0.67, 95% CI 0.46–0.98, p =.016). Between the early and late periods, the use of corticosteroids (≥6 mg dexamethasone/day) and remdesivir increased (62/571 [10.9%] vs. 243/402 [61.5%], p <.001 and 50/571 [8.8%] vs. 213/402 [52.2%], p <.001, respectively), and the use of hydroxychloroquine and IL-6/IL-6 receptor inhibitor decreased (329/571 [60.0%] vs. 4/492 [1.0%], p <.001 and 73/571 [12.8%] vs. 5/402 [1.2%], p <.001, respectively). Mortality among SOTR hospitalized for COVID-19 declined between early and late 2020, consistent with trends reported in the general population. The mechanism(s) underlying improved survival require further study

JIRAM, the Jovian Infrared Auroral Mapper

JIRAM is an imager/spectrometer on board the Juno spacecraft bound for a polar orbit around Jupiter. JIRAM is composed of IR imager and spectrometer channels. Its scientific goals are to explore the Jovian aurorae and the planet's atmospheric structure, dynamics and composition. This paper explains the characteristics and functionalities of the instrument and reports on the results of ground calibrations. It discusses the main subsystems to the extent needed to understand how the instrument is sequenced and used, the purpose of the calibrations necessary to determine instrument performance, the process for generating the commanding sequences, the main elements of the observational strategy, and the format of the scientific data that JIRAM will produce

Randomized, Double‐Blind Trial of Anidulafungin Versus Fluconazole for Prophylaxis of Invasive Fungal Infections in High‐Risk Liver Transplant Recipients

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/109578/1/ajt12963.pd

Analysis of 3D bone ingrowth into polymer scaffolds via micro-computed tomography imaging

10.1016/j.biomaterials.2004.01.047Biomaterials25204947-4954BIMA

Neptune’s zonal winds from near-IR Keck adaptive optics imaging in August 2001

We present H-band (1.4–1.8 ?m) images of Neptune with a spatial resolution of ?0.06?, taken with the W.M. Keck II telescope using the slit-viewing camera (SCAM) of the NIRSPEC instrument backed with Adaptive Optics. Images with 60-second integration times span 4 hours each on UT 20 and 21 August, 2001 and ?1 hour on UT 1 September, 2001. These images were used to characterize the overall brightness distribution on Neptune, and to determine rotations periods (which translate into wind speeds) of individual cloud features. The images show that the spatial brightness distribution of cloud features, in particular the bright bands at mid-southern latitudes and near 30°N, changed considerably between 1989 (Voyager era) and 2001. The brightest features extend latitudinally over several degrees, and despite the different velocities in different latitude bands, these bright features remain coherent. We show that these features are bright in part because of the foreshortening effect near the limb, which suggests that the features may be composed of small bright clouds that happen to line up near the limb. At certain latitudes (mid-southern and northern latitudes), there is considerable dispersion in relative rotation periods (and hence zonal velocities) of faint and moderately bright features, while there is essentially no velocity dispersion of features at 50°S. While the zonal speeds of the brightest features are consistent with the Voyager-derived zonal-mean wind profile, there are many cloud features that do not appear to move with the flow. The data are further suggestive of oscillations in longitude, with periods > 4 hrs. We suggest that tidal forcing by Triton could play a role in exciting the waves responsible for the velocity variations of the observed period.Space EngineeringAerospace Engineerin