Humor attenuates the cortisol awakening response in healthy older men

This study examined the impact of an important factor contributing to successful aging, humor, on post-awakening cortisol levels among a group of 45 older men whose ages ranged from 64 years to 86 years (mean = 73.6 years). Four saliva samples were collected from the participants for 2 days immediately after waking and every 15 min thereafter for three times. Cortisol data of the 2 days were aggregated for analysis. Two separate indices of cortisol awakening response reflecting the mean level of secretion and the rise from immediately to 45 min post-awakening, AUCG and AUCI, were computed using the trapezoid formula. The relation of these two indices to humor (operationalized as coping) was examined in a multiple regression analysis while controlling for the effect of age, socioeconomic status, and self-esteem. Results indicated that higher humor scores were associated with lower AUCG but had no relation with AUCI. Findings of the present study suggest that the hypothalamic-pituitary-adrenocortical axis is the major pathway whereby positive psychological dispositions, such as humor, exert their health effects in the aging population. Moreover, cortisol levels in the awakening period may be particularly sensitive to the influences of psychosocial factors

Relationship between circulating vascular endothelial growth factor and its soluble receptors in adults with dengue virus infection: a case-control study

International Journal of Infectious Diseases135e248-e25

Targeted drug discovery for Alzheimer disease: abridged secondary publication

Hong Kong SAR Governmen

Oxidative damage in Parkinson disease: Measurement using accurate biomarkers

10.1016/j.freeradbiomed.2009.11.026Free Radical Biology and Medicine484560-566FRBM