Значение очагового поражения головного мозга в развитии вестибулярных и слуховых нарушений у больных рассеянным склерозом

We have examined 72 patients aged from 18 till 62 with cerebral and cerebrospinal multiple sclerosis (MS) form. All patients have been underwent оtoneurologiс examination, electronystagmography (ENG), caloric tests, pure-tone audiometry, high frequency audiometry up to 20 kHz, impedance audiometry, auditory brainstem responses (ABR), magnetic resonance imaging (MRI). 59 patients had pathologically changed in MRI demyelination lesion in the brainstem. Demyelinization of the brainstem affects acoustical and vestibular function in patients with multiple sclerosis. Pathological changes of pure-tone audiometry, high frequency audiometry, acoustic reflexes and ABR may be regarded as subclinical signs of demyelinization of the cochleovestibular analyzer.Мы исследовали 72 пациента с церебральной и цереброспинальной формой рассеянного склероза в возрасте от 18 до 62 лет. Всем пациентам проведено отоневрологические обследование экспериментального калорического нистагма методом компьютерной электронистагмографии (КЭНГ), тональная пороговая аудиометрия в расширенном диапазоне частот до 20 кГц, акустическая рефлексометрия, исследование коротколатентных слуховых вызванных потенциалов (КСВП) и магниторезонансная томография головного мозга. В 59 случаях визуализированы очаги демиелинизации в стволе головного мозга. Выявлена взаимосвязь очагового стволового поражения и нарушения слуховой и вестибулярной функции у больных рассеянным склерозом. Патологические изменения тонального слуха, акустических рефлексов и КСВП могут быть субклиническими признаками демиелинизирующего повреждения кохлеовестибулярного анализатора

Ancestral diversity improves discovery and fine-mapping of genetic loci for anthropometric traits — The Hispanic/Latino Anthropometry Consortium

Hispanic/Latinos have been underrepresented in genome-wide association studies (GWAS) for anthropometric traits despite their notable anthropometric variability, ancestry proportions, and high burden of growth stunting and overweight/obesity. To address this knowledge gap, we analyzed densely imputed genetic data in a sample of Hispanic/Latino adults to identify and fine-map genetic variants associated with body mass index (BMI), height, and BMI-adjusted waist-to-hip ratio (WHRadjBMI). We conducted a GWAS of 18 studies/consortia as part of the Hispanic/Latino Anthropometry (HISLA) Consortium (stage 1, n = 59,771) and generalized our findings in 9 additional studies (stage 2, n = 10,538). We conducted a trans-ancestral GWAS with summary statistics from HISLA stage 1 and existing consortia of European and African ancestries. In our HISLA stage 1 + 2 analyses, we discovered one BMI locus, as well as two BMI signals and another height signal each within established anthropometric loci. In our trans-ancestral meta-analysis, we discovered three BMI loci, one height locus, and one WHRadjBMI locus. We also identified 3 secondary signals for BMI, 28 for height, and 2 for WHRadjBMI in established loci. We show that 336 known BMI, 1,177 known height, and 143 known WHRadjBMI (combined) SNPs demonstrated suggestive transferability (nominal significance and effect estimate directional consistency) in Hispanic/Latino adults. Of these, 36 BMI, 124 height, and 11 WHRadjBMI SNPs were significant after trait-specific Bonferroni correction. Trans-ancestral meta-analysis of the three ancestries showed a small-to-moderate impact of uncorrected population stratification on the resulting effect size estimates. Our findings demonstrate that future studies may also benefit from leveraging diverse ancestries and differences in linkage disequilibrium patterns to discover novel loci and additional signals with less residual population stratification

Aerobic Co or Cu/NHPI-catalyzed oxidation of hydride siloxanes: Synthesis of siloxanols

A highly efficient preparative method for the synthesis of siloxanols based on aerobic Co(OAc)2 or Cu(OAc)2/NHPI-catalyzed oxidation of hydride siloxanes using "green", commercially available, simple inexpensive reagents and mild reaction conditions has been proposed. This is a general reaction for the synthesis of mono-, oligo- and polymeric siloxanols with various structures (linear, branched and cyclic). © 2018 The Royal Society of Chemistry

Aerobic Co or Cu/NHPI-catalyzed oxidation of hydride siloxanes: Synthesis of siloxanols

A highly efficient preparative method for the synthesis of siloxanols based on aerobic Co(OAc)2 or Cu(OAc)2/NHPI-catalyzed oxidation of hydride siloxanes using "green", commercially available, simple inexpensive reagents and mild reaction conditions has been proposed. This is a general reaction for the synthesis of mono-, oligo- and polymeric siloxanols with various structures (linear, branched and cyclic). © 2018 The Royal Society of Chemistry