24 research outputs found

    Riociguat treatment in patients with chronic thromboembolic pulmonary hypertension: Final safety data from the EXPERT registry

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    Objective: The soluble guanylate cyclase stimulator riociguat is approved for the treatment of adult patients with pulmonary arterial hypertension (PAH) and inoperable or persistent/recurrent chronic thromboembolic pulmonary hypertension (CTEPH) following Phase

    Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

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    Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

    Effect of temperature and pressure on mechanical, surface and electrochemical properties of Al-1.5Cu-5.5Zn-2.5Mg (Alumix-431)

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    Purpose: The purpose of this paper is to examine new alloys created from Alumix 431 powder and investigate their mechanical and electrochemical properties. Design/methodology/approach: In this study; Alumix-431 alloy samples were prepared using the powder metallurgy (P/M) method applying cold (RT) and warm (50°C and 80°C) compaction methods under pressures of 200 and 250 MPa and were sintered at 600°C in N2(g) atmosphere. Hardness and density of the samples were measured, and corrosion properties were determined by electrochemical impedance spectroscopy charting polarization curves. Surface characterization was determined by contact angle, scanning electron microscopy/mapping, energy dispersive X-ray spectrometry and X-ray diffractometry images. Findings: Alumix-431 alloys obtained upon compaction at 250 MPa/50 °C had the highest mechanical properties and corrosion resistance and good surface properties. On the surfaces of Alumix-431 alloys, ?-Al, MgZn2, Al2,CuMg, Al2,O3, Al2MgO4 phases were recorded. Originality/value: This study aimed to construct a correlation between mechanical and electrochemical properties of the newly created alloys (prepared under special conditions). © 2018, Emerald Publishing Limited

    Registration of Common Bacterial Blight Resistant Pinto Bean Germplasm Line ABCP-8

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    Pinto bean (Phaseolus vulgaris L.) germplasm line ABCP-8 (Reg. no. GP-237, PI 635118) was developed by the University of Nebraska Agricultural Research Division in cooperation with USDA-ARS and released in 2004. This line was bred specifically for enhanced resistnace to common bacterial blight [caused by Xanthomonas campestris pv. phaseoli (Smith) Dye]. Pinto and other dry bean market classes (dark red kidney, great northern, navy, etc.) grown in the U.S.A. east of the continental divide are often attacked by common bacterial blight, a seed-transmitted disease that causes up to 40% yield loss in susceptible cultivars as well as reduction of seed quality through discoloration of infected seed. Development of cultivars with genetic resistance combined from different sources is the most cost effective method to control common bacterial blight
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