Study of heterogeneous nucleation of eutectic Si in high-purity Al-Si alloys with Sr addition

The official published version can be accessed from the link below - Copyright @ 2010 The Minerals, Metals & Materials Society and ASM InternationalAl-5 wt pct Si master-alloys with controlled Sr and/or P addition/s were produced using super purity Al 99.99 wt pct and Si 99.999 wt pct materials in an arc melter. The master-alloy was melt-spun resulting in the production of thin ribbons. The Al matrix of the ribbons contained entrained Al-Si eutectic droplets that were subsequently investigated. Differential scanning calorimetry, thermodynamic calculations, and transmission electron microscopy techniques were employed to examine the effect of the Sr and P additions on eutectic undercoolings and nucleation phenomenon. Results indicate that, unlike P, Sr does not promote nucleation. Increasing Sr additions depressed the eutectic nucleation temperature. This may be a result of the formation of a Sr phase that could consume or detrimentally affect potent AlP nucleation sites.This work is financially supported by the Higher Education Commission of Pakistan and managerially supported from the OAD

Termoreverzibilni mukoadhezivni in situ hidrogel za oftalmičku primjenu: dizajniranje i optimizacija koristeći kombinaciju polimera

The purpose of the study was to develop an optimized thermoreversible in situ gelling ophthalmic drug delivery system based on Pluronic F 127, containing moxifloxacin hydrochloride as a model drug. A 32 full factorial design was employed with two polymers Pluronic F 68 and Gelrite as independent variables used in combination with Pluronic F 127. Gelation temperature, gel strength, bioadhesion force, viscosity and in vitro drug release after 1 and 10 h were selected as dependent variables. Pluronic F 68 loading with Pluronic F 127 was found to have a significant effect on gelation temperature of the formulation and to be of importance for gel formation at temperatures 3336 ºC. Gelrite loading showed a positive effect on bioadhesion force and gel strength and was also found helpful in controling the release rate of the drug. The quadratic mathematical model developed is applicable to predicting formulations with desired gelation temperature, gel strength, bioadhesion force and drug release properties.Cilj rada bio je razvoj i optimizacija termoreverzibilnog sustava za isporuku lijekova koji gelira in situ. Sustav je napravljen na bazi Pluronic F 127, a sadrži moksifloksacin hidroklorid kao modelni lijek. U radu je primjenjeno 32 potpuno faktorijsko dizajniranje s dva polimera, Pluronic F 68 i Gelrite kao nezavisnim varijablama koji su kombinirani s Pluronic F 127. Kao zavisne varijable odabrane su temperatura geliranja, čvrstoća gela, jačina bioadhezije, viskoznost i in vitro oslobađanje lijeka nakon 1 i 10 h. Pronađeno je da Pluronic F 68 u kombinaciji s Pluronic F 127 ima značajan učinak na temperaturu geliranja u rasponu od 33 do 36 C. S druge strane, Gelrite ima povoljan učinak na jačinu bioadhezije, čvrstoću gela i oslobađanje lijeka. Razvijen je kvadratni matematički model pomoću kojeg se može predvidjeti temperatura geliranja, čvrstoća gela, jačina bioadhezije i oslobađanje ljekovite tvari

The nature of social dominance orientation: theorizing and measuring preferences for intergroup inequality using the new SDO₇ scale

A new conceptualization and measurement of social dominance orientation-individual differences in the preference for group based hierarchy and inequality-is introduced. In contrast to previous measures of social dominance orientation that were designed to be unidimensional, the new measure (SDO7) embeds theoretically grounded subdimensions of SDO-SDO-Dominance (SDO-D) and SDO-Egalitarianism (SDO-E). SDO-D constitutes a preference for systems of group-based dominance in which high status groups forcefully oppress lower status groups. SDO-E constitutes a preference for systems of group-based inequality that are maintained by an interrelated network of subtle hierarchy-enhancing ideologies and social policies. Confirmatory factor and criterion validity analyses confirmed that SDO-D and SDO-E are theoretically distinct and dissociate in terms of the intergroup outcomes they best predict. For the first time, distinct personality and individual difference bases of SDO-D and SDO-E are outlined. We clarify the construct validity of SDO by strictly assessing a preference for dominance hierarchies in general, removing a possible confound relating to support for hierarchy benefitting the ingroup. Consistent with this, results show that among members of a disadvantaged ethnic minority group (African Americans), endorsement of SDO7 is inversely related to ingroup identity. We further demonstrate these effects using nationally representative samples of U.S. Blacks and Whites, documenting the generalizability of these findings. Finally, we introduce and validate a brief 4-item measure of each dimension. This article importantly extends our theoretical understanding of one of the most generative constructs in social psychology, and introduces powerful new tools for its measurement

Author Correction: The genetic legacy of continental scale admixture in Indian Austroasiatic speakers

This Article contains errors in the Methods section, under subsection ‘Samples collection and genotyping’

Resonances in the three-neutron system

A study of 3-body resonances has been performed in the framework of configuration space Faddeev equations. The importance of keeping a sufficient number of terms in the asymptotic expansion of the resonance wave function is pointed out. We investigated three neutrons interacting in selected force components taken from realistic nn forces.Comment: 38 pages, 11 tables, 4 figure

Quantum trajectory perspective of atom-field interaction in attosecond time scale

Here the ionization and high harmonic generation in Hydrogen and Helium by using quantum (hydrodynamic) trajectories is analyzed theoretically. The quantum trajectories allow a self-contained treatment of the electron exchange and correlation effects without introducing ad hoc potentials into the Schrodinger equation. Our approach predicts the correct high harmonic spectra and the attosecond pulses generated by the Helium atom beyond the single active electron approximation. It can be used to study complex multi-electron systems and their interaction with laser field of both high and low intensity.Comment: 8 pages, 4 figure

First-order interference of nonclassical light emitted spontaneously at different times

We study first-order interference in spontaneous parametric down-conversion generated by two pump pulses that do not overlap in time. The observed modulation in the angular distribution of the signal detector counting rate can only be explained in terms of a quantum mechanical description based on biphoton states. The condition for observing interference in the signal channel is shown to depend on the parameters of the idler radiation.Comment: 5 pages, two-column, submitted to PR

Non-paraxial Split-step Finite-difference Method for Beam Propagation

A method based on symmetrized splitting of the propagation operator in the finite difference scheme for non-paraxial beam propagation is presented. The formulation allows the solution of the second order scalar wave equation without having to make the slowly varying envelope and one-way propagation approximations. The method is highly accurate and numerically efficient. Unlike most Padé approximant based methods, it is non-iterative in nature and requires less computation. The method can be used for bi-directional propagation as well

Intrinsic MYH7 expression regulation contributes to tissue level allelic imbalance in hypertrophic cardiomyopathy

HCM, the most common inherited cardiac disease, is mainly caused by mutations in sarcomeric genes. More than a third of the patients are heterozygous for mutations in the MYH7 gene encoding for the β-myosin heavy chain. In HCM-patients, expression of the mutant and the wildtype allele can be unequal, thus leading to fractions of mutant and wildtype mRNA and protein which deviate from 1:1. This so-called allelic imbalance was detected in whole tissue samples but also in individual cells. There is evidence that the severity of HCM not only depends on the functional effect of the mutation itself, but also on the fraction of mutant protein in the myocardial tissue. Allelic imbalance has been shown to occur in a broad range of genes. Therefore, we aimed to examine whether the MYH7-alleles are intrinsically expressed imbalanced or whether the allelic imbalance is solely associated with the disease. We compared the expression of MYH7-alleles in non-HCM donors and in HCM-patients with different MYH7-missense mutations. In the HCM-patients, we identified imbalanced as well as equal expression of both alleles. Also at the protein level, allelic imbalance was determined. Most interestingly, we also discovered allelic imbalance and balance in non-HCM donors. Our findings therefore strongly indicate that apart from mutation-specific mechanisms, also non-HCM associated allelic-mRNA expression regulation may account for the allelic imbalance of the MYH7 gene in HCM-patients. Since the relative amount of mutant mRNA and protein or the extent of allelic imbalance has been associated with the severity of HCM, individual analysis of the MYH7-allelic expression may provide valuable information for the prognosis of each patient

Integrated Genomic Analysis of Diverse Induced Pluripotent Stem Cells from the Progenitor Cell Biology Consor tium

The rigorous characterization of distinct induced pluripotent stem cells (iPSC) derived from multiple reprogramming technologies, somatic sources, and donors is required to understand potential sources of variability and downstream potential. To achieve this goal, the Progenitor Cell Biology Consortium performed comprehensive experimental and genomic analyses of 58 iPSC from ten laboratories generated using a variety of reprogramming genes, vectors, and cells. Associated global molecular characterization studies identified functionally informative correlations in gene expression, DNA methylation, and/or copy-number variation among key developmental and oncogenic regulators as a result of donor, sex, line stability, reprogramming technology, and cell of origin. Furthermore, X-chromosome inactivation in PSC produced highly correlated differences in teratoma-lineage staining and regulator expression upon differentiation. All experimental results, and raw, processed, and metadata from these analyses, including powerful tools, are interactively accessible from a new online portal at https://www.synapse.org to serve as a reusable resource for the stem cell community