Quantitative detection of atropine-delayed gastric emptying in the horse by the ¹³C-octanoic acid breath test

The <sup>13</sup>C-octanoic acid breath test has been correlated significantly to radioscintigraphy for measurement of gastric emptying indices in healthy horses. The objective of this study was to investigate the validity of the test for measurement of equine delayed gastric emptying, prior to its potential clinical application for this purpose. A model of atropine- induced gastroparesis was used. Gastric emptying rate was measured twice in 8 horses using concurrent radioscintigraphy and/or breath test after treatment i.v. with either atropine (0.035 mg/kg bwt) or saline in randomised order. Analysis of both data sets demonstrated that the atropine treatment had caused a significant delay in gastric emptying rate. Paired breath test data showed an atropine-induced delay in gastric half-emptying time t(1/2)), with no overlap in the 99% Cl range (P<0.001). Significant correlations were found between scintigraphy and <sup>13</sup>C-octanoic acid breath test for calculation of both t(1/2) (P<0.01) and lag phase duration (P<0.05) in the atropine-delayed emptying results. The mean (s.d.) bias in breath test t(1/2) when compared with scintigraphy was 1.78 (0.58) h. The results demonstrated that the <sup>13</sup>C-octanoic acid breath test was an effective diagnostic modality for the measurement of equine delayed gastric emptying. The technique offers advantages to existing methods for clinical investigation, as it is noninvasive, not radioactive, quantitative and requires minimal equipment or training to perform

My Dear Eve…: The Remaining Letters from Eve’s Rutherford File

Throughout their lives, Ernest Rutherford and his wife Mary wrote and received many letters of a chatty, impersonal nature, many of which have previously been published. This article comprises a number of hitherto unpublished letters written by Mary Rutherford at the time of her husband’s terminal illness in 1937, and subsequently. The article also includes the full text of a letter written by Rutherford to his wife in 1914, a condensed version of which was included in Eve’s 1939 biography of Rutherford.ResuméTout au long de leurs vies, Ernest Rutherford et son épouse Mary ont écrit et reçu une grande quantité de lettres de nature impersonnelle et pleines de bavardage, dont plusieurs ont déjà été publiées. Cet article présente un certain nombre de lettres inédites écrites par Mary Rutherford à l’époque de la maladie qui allait emporter son mari en 1937, et au cours des années suivantes. L’article comprend également le texte intégral d’une lettre écrite par Ernest Rutherford à sa femme en 1914, dont une version abrégée a été publiée dans la biographie de Rutherford écrite par Eve en 1939

Spacetime symmetries of the Lorentz-violating Maxwell-Chern-Simons model

The spacetime symmetries of classical electrodynamics supplemented with a Chern-Simons term that contains a constant nondynamical 4-vector are investigated. In addition to translation invariance and the expected three remaining Lorentz symmetries characterized by the little group of the external vector, the model possesses an additional spacetime symmetry if the nondynamical vector is lightlike. The conserved current associated with this invariance is determined, and the symmetry structure arising from this invariance and the usual little group ISO(2) is identified as SIM(2).Comment: 5 pages, 1 table, REVTeX

Excited Baryon Decay Widths in Large N_c QCD

We study excited baryon decay widths in large N_c QCD. It was suggested previously that some spin-flavor mixed-symmetric baryon states have strong couplings of O(N_c^{-1/2}) to nucleons [implying narrow widths of O(1/N_c)], as opposed to the generic expectation based on Witten's counting rules of an O(N_c^0) coupling. The calculation obtaining these narrow widths was performed in the context of a simple quark-shell model. This paper addresses the question of whether the existence of such narrow states is a general property of large N_c QCD. We show that a general large N_c QCD analysis does not predict such narrow states; rather they are a consequence of the extreme simplicity of the quark model.Comment: 9 page

Naturaliste plateau: constraints on the timing and evolution of the Kerguelen Large Igneous Province and its role in Gondwana breakup

Volcanism associated with the Kerguelen Large Igneous Province is found scattered in southwestern Australia (the ca 136 to ca 130 Ma Bunbury Basalts, and ca 124 Ma Wallaby Plateau), India (ca 118 Ma Rajmahal Traps and Cona Basalts), and Tibet (the ca 132 Ma Comei Basalts), but apart from the ∼70 000 km2 Wallaby Plateau, these examples are spatially and volumetrically minor. Here, we report dredge, geochronological and geochemical results from the ∼90 000 km2 Naturaliste Plateau, located ∼170 to ∼500 km southwest of Australia. Dredged lavas and intrusive rocks range from mafic to felsic compositions, and prior geophysical analyses indicate these units comprise much of the plateau substrate. 40Ar/39Ar plagioclase ages from mafic units and U–Pb zircon ages from silicic rocks indicate magmatic emplacement from 130.6 ± 1.2 to 129.4 ± 1.3 Ma for mafic rocks and 131.8 ± 3.9 to 128.2 ± 2.3 Ma for silicic rocks (2σ). These Cretaceous Naturaliste magmas incorporated a significant component of continental crust, with relatively high 87Sr/86Sr (up to 0.78), high 207Pb/204 Pb ratios (15.5–15.6), low 143Nd/144Nd (0.511–0.512) and primitive-mantle normalised Th/Nb of 11.3 and La/Nb of 3.97. These geochemical results are consistent with the plateau being underlain by continental basement, as indicated by prior interpretations of seismic and gravity data, corroborated by dredging of Mesoproterozoic granites and gneisses on the southern plateau flank. The Cretaceous Naturaliste Plateau igneous rocks have signatures indicative of extraction from a depleted mantle, with trace-element and isotopic values that overlap with Kerguelen Plateau lavas reflect crustal contamination. Our chemical and geochronological results therefore show the Naturaliste Plateau contains evidence of an extensive igneous event representing some of the earliest voluminous Kerguelen hotspot magmas. Prior work reports that contemporaneous correlative volcanic sequences underlie the nearby Mentelle Basin, and the Enderby Basin and Princess Elizabeth Trough in the Antarctic. When combined, the igneous rocks in the Naturaliste, Mentelle, Wallaby, Enderby, Princess Elizabeth, Bunbury and Comei-Cona areas form a 136–124 Ma Large Igneous Province covering >244 000 km2

Flexible Invariants Through Semantic Collaboration

Modular reasoning about class invariants is challenging in the presence of dependencies among collaborating objects that need to maintain global consistency. This paper presents semantic collaboration: a novel methodology to specify and reason about class invariants of sequential object-oriented programs, which models dependencies between collaborating objects by semantic means. Combined with a simple ownership mechanism and useful default schemes, semantic collaboration achieves the flexibility necessary to reason about complicated inter-object dependencies but requires limited annotation burden when applied to standard specification patterns. The methodology is implemented in AutoProof, our program verifier for the Eiffel programming language (but it is applicable to any language supporting some form of representation invariants). An evaluation on several challenge problems proposed in the literature demonstrates that it can handle a variety of idiomatic collaboration patterns, and is more widely applicable than the existing invariant methodologies.Comment: 22 page

Categorification of persistent homology

We redevelop persistent homology (topological persistence) from a categorical point of view. The main objects of study are diagrams, indexed by the poset of real numbers, in some target category. The set of such diagrams has an interleaving distance, which we show generalizes the previously-studied bottleneck distance. To illustrate the utility of this approach, we greatly generalize previous stability results for persistence, extended persistence, and kernel, image and cokernel persistence. We give a natural construction of a category of interleavings of these diagrams, and show that if the target category is abelian, so is this category of interleavings.Comment: 27 pages, v3: minor changes, to appear in Discrete & Computational Geometr

The mass insertion approximation without squark degeneracy

We study the applicability of the mass insertion approximation (MIA) for calculations of neutral meson mixing when squark masses are not degenerate and, in particular, in models of alignment. We show that the MIA can give results that are much better than an order of magnitude estimate as long as the masses are not strongly hierarchical. We argue that, in an effective two-squark framework, m_q=(m_1+m_2)/2 is the best choice for the MIA expansion point, rather than, for example, m_q^2=(m_1^2+m_2^2)/2.Comment: 7 pages, revtex

Motivation in physical education across the primary-secondary school transition

The purpose of this study was to examine the temporal patterns of approach-avoidance achievement goals, implicit theories of ability and perceived competence in physical education across the transition from primary to secondary school. We also evaluated the predictive utility of implicit theories and perceived competence with regard to achievement goal adoption, and determined the moderating influence of gender on temporal patterns and antecedent–goal relationships. One hundred and forty pupils (mean age at start of study = 11.37 years, SD =.28) completed measures of entity and incremental beliefs, perceived competence and goals on four occasions during a 12-month period. Mastery-approach, performance-approach and perform-ance-avoidance goals, as well as entity and incremental beliefs, exhibited a linear decline over time. Mastery-avoidance goals showed no significant change. Girls exhibited a linear decline in perceived competence, whereas for boys the trajectory was curvilinear. Competence perceptions predicted initial scores, but not rate of change, on mastery-approach and both types of performance goals. Incrementa

Chaotic dynamics of cold atoms in far-off-resonant donut beam

We describe the classical two dimensinal nonlinear dynamics of cold atoms in far-off-resonant donut beams. We show that there chaotic dynamics exists for charge greater than unity, when the intensity of the beam is periodically modulated. The two dimensional distributions of atoms in $(x,y)$ plane for charge two are simulated. We show that the atoms will acumulate on several ring regions when the system enters to regime of global chaos.Comment: 8 pages, 8 figure