A standardised model for stool banking for faecal microbiota transplantation: a consensus report from a multidisciplinary UEG working group

Background Faecal microbiota transplantation is an emerging therapeutic option, particularly for the treatment of recurrent Clostridioides difficile infection. Stool banks that organise recruitment and screening of faeces donors are being embedded within the regulatory frameworks described in the European Union Tissue and Cells Directive and the technical guide to the quality and safety of tissue and cells for human application, published by the European Council.Objective Several European and international consensus statements concerning faecal microbiota transplantation have been issued. While these documents provide overall guidance, we aim to provide a detailed description of all processes that relate to the collection, handling and clinical application of human donor stool in this document.Methods Collaborative subgroups of experts on stool banking drafted concepts for all domains pertaining to stool banking. During a working group meeting in the United European Gastroenterology Week 2019 in Barcelona, these concepts were discussed and finalised to be included in our overall guidance document about faecal microbiota transplantation.Results A guidance document for all domains pertaining to stool banking was created. This document includes standard operating manuals for several processes involved with stool banking, such as handling of donor material, storage and donor screening.Conclusion The implementation of faecal microbiota transplantation by stool banks in concordance with our guidance document will enable quality assurance and guarantee the availability of donor faeces preparations for patients.Molecular basis of bacterial pathogenesis, virulence factors and antibiotic resistanc

Rational for the use of children's motor activity as a criterion for the effectiveness of rehabilitation and recreation

<p>Purpose – justified the use of physical activity for children as a criterion for recreation. Studied the relationship of this index with morphological and functional features of development and the level of hygiene knowledge. The study involved 54 pupils aged 10-14 years. Results: It is shown that the level of physical activity (1282,37 ± 289,20) locomotion per day. The value of basal metabolism reaches (1350,51 ± 33,69) kcal. Established direct correlation with the main motor activity exchange (r = 0,81); body weight (r = 0,80); circumference of the chest in the pause / inspiratory / expiratory (r = 0,70-0,71); vital capacity (r = 0,37); hand muscular strength (r = 0,51-0,58). The estimation of the physical development of children by Quetelet index: mass deficit is set at 12.96%, 29.63% obese, normal physical development at 51.85% overweight at 5.56%. Conclusions: The recommended value of physical activity as a criterion for recreation and health of school children. Its definition reflects the functional state of the school, as one of the criteria for defining the health, predicts its changes, which is especially valuable in monitoring.</p

Digital Signal Processing for the GABRIELA Detector Assembly

International audienceThis paper briefly describes the main ways of digital signal processing. The goal of the digital algorithms is to reduce the dead time of the spectrometry path to tens of nanoseconds without loss of energy and time resolutions. The new kσ-trigger with extrapolation technique is proposed in the paper. The method allows to find overlapped signals almost irrespective of their closeness in time

The emission of prompt neutrons from the spontaneous fission of No-252 and Fm-244

The neutron detector with (3)He -filled counters placed in the focal plane of the VASSILISSA separator is used for measuring the average number and determining the multiplicity distribution of prompt neutrons from the spontaneous fission of heavy short-lived isotopes. The test reaction is used for tuning the separator settings and calibrating the detector system with the spontaneous fission of the (252)No . The average neutron number per (252)No spontaneous fission event is as large as . The short-lived heavy isotope (244)Fm , produced in the complete fusion reaction (40)Ar + (206)Pb , is investigated. The average number of neutrons per spontaneous fission of (244)Fm from the experimental data ( is determined for the first time