Black Hole Chromosphere at the LHC

If the scale of quantum gravity is near a TeV, black holes will be copiously produced at the LHC. In this work we study the main properties of the light descendants of these black holes. We show that the emitted partons are closely spaced outside the horizon, and hence they do not fragment into hadrons in vacuum but more likely into a kind of quark-gluon plasma. Consequently, the thermal emission occurs far from the horizon, at a temperature characteristic of the QCD scale. We analyze the energy spectrum of the particles emerging from the "chromosphere", and find that the hard hadronic jets are almost entirely suppressed. They are replaced by an isotropic distribution of soft photons and hadrons, with hundreds of particles in the GeV range. This provides a new distinctive signature for black hole events at LHC.Comment: Incorporates changes made for the version to be published in Phys. Rev. D. Additional details provided on the effect of the chromosphere in cosmic ray shower

TBCRC 002: A phase II, randomized, open-label trial of preoperative letrozole with or without bevacizumab in postmenopausal women with newly diagnosed stage 2/3 hormone receptor-positive and HER2-negative breast cancer

Background: In preclinical studies, the expression of vascular endothelial growth factor (VEGF) in hormone receptor-positive breast cancer is associated with estrogen-independent tumor growth and resistance to endocrine therapies. This study investigated whether the addition of bevacizumab, a monoclonal antibody against VEGF, to letrozole enhanced the antitumor activity of the letrozole in the preoperative setting. Methods: Postmenopausal women with newly diagnosed stage 2 or 3 estrogen and/or progesterone receptor-positive, HER2-negative breast cancer were randomly assigned (2:1) between letrozole 2.5 mg PO daily plus bevacizumab 15 mg/kg IV every 3 weeks (Let/Bev) and letrozole 2.5 mg PO daily (Let) for 24 weeks prior to definitive surgery. Primary objective was within-arm pathologic complete remission (pCR) rate. Secondary objectives were safety, objective response, and downstaging rate. Results: Seventy-five patients were randomized (Let/Bev n = 50, Let n = 25). Of the 45 patients evaluable for pathological response in the Let/Bev arm, 5 (11%; 95% CI, 3.7-24.1%) achieved pCR and 4 (9%; 95% CI, 2.5-21.2%) had microscopic residual disease; no pCRs or microscopic residual disease was seen in the Let arm (0%; 95% CI, 0-14.2%). The rates of downstaging were 44.4% (95% CI, 29.6-60.0%) and 37.5% (95% CI, 18.8-59.4%) in the Let/Bev and Let arms, respectively. Adverse events typically associated with letrozole (hot flashes, arthralgias, fatigue, myalgias) occurred in similar frequencies in the two arms. Hypertension, headache, and proteinuria were seen exclusively in the Let/Bev arm. The rates of grade 3 and 4 adverse events and discontinuation due to adverse events were 18% vs 8% and 16% vs none in the Let/Bev and Let arms, respectively. A small RNA-based classifier predictive of response to preoperative Let/Bev was developed and confirmed on an independent cohort. Conclusion: In the preoperative setting, the addition of bevacizumab to letrozole was associated with a pCR rate of 11%; no pCR was seen with letrozole alone. There was additive toxicity with the incorporation of bevacizumab. Responses to Let/Bev can be predicted from the levels of 5 small RNAs in a pretreatment biopsy. Trial registration: This trial is registered with ClinicalTrials.gov (Identifier: NCT00161291), first posted on September 12, 2005, and is completed

Mitochondrial Mutations in Subjects with Psychiatric Disorders

A considerable body of evidence supports the role of mitochondrial dysfunction in psychiatric disorders and mitochondrial DNA (mtDNA) mutations are known to alter brain energy metabolism, neurotransmission, and cause neurodegenerative disorders. Genetic studies focusing on common nuclear genome variants associated with these disorders have produced genome wide significant results but those studies have not directly studied mtDNA variants. The purpose of this study is to investigate, using next generation sequencing, the involvement of mtDNA variation in bipolar disorder, schizophrenia, major depressive disorder, and methamphetamine use. MtDNA extracted from multiple brain regions and blood were sequenced (121 mtDNA samples with an average of 8,800x coverage) and compared to an electronic database containing 26,850 mtDNA genomes. We confirmed novel and rare variants, and confirmed next generation sequencing error hotspots by traditional sequencing and genotyping methods. We observed a significant increase of non-synonymous mutations found in individuals with schizophrenia. Novel and rare non-synonymous mutations were found in psychiatric cases in mtDNA genes: ND6, ATP6, CYTB, and ND2. We also observed mtDNA heteroplasmy in brain at a locus previously associated with schizophrenia (T16519C). Large differences in heteroplasmy levels across brain regions within subjects suggest that somatic mutations accumulate differentially in brain regions. Finally, multiplasmy, a heteroplasmic measure of repeat length, was observed in brain from selective cases at a higher frequency than controls. These results offer support for increased rates of mtDNA substitutions in schizophrenia shown in our prior results. The variable levels of heteroplasmic/multiplasmic somatic mutations that occur in brain may be indicators of genetic instability in mtDNA

Evidence for mass accretion driven by spiral shocks onto the white dwarf in SDSS J123813.73–033933.0

We present high-time-resolution photometry and phase-resolved spectroscopy of the short-period (⁠Porb=80.52min⁠) cataclysmic variable SDSS J123813.73–033933.0, observed with the Hubble Space Telescope (HST), the Kepler/K2 mission, and the Very Large Telescope (VLT). We also report observations of the first detected superoutburst. SDSS J1238–0339 shows two types of variability: quasi-regular brightenings recurring every ≃8.5  h during which the system increases in brightness by ≃0.5mag, and a double-hump quasi-sinusoidal modulation at the orbital period. The detailed K2 light curve reveals that the amplitude of the double-humps increases during the brightenings and that their phase undergoes a ≃90° phase shift with respect to the quiescent intervals. The HST  data unambiguously demonstrate that these phenomena both arise from the heating and cooling of two relatively large regions on the white dwarf. We suggest that the double-hump modulation is related to spiral shocks in the accretion disc resulting in an enhanced accretion rate heating two localized regions on the white dwarf, with the structure of the shocks fixed in the binary frame explaining the period of the double humps. The physical origin of the 8.5  h brightenings is less clear. However, the correlation between the observed variations of the amplitude and phase of the double-humps with the occurrence of the brightenings is supportive of an origin in thermal instabilities in the accretion disc

Constraining the evolution of cataclysmic variables via the masses and accretion rates of their underlying white dwarfs

We report on the masses (MWD), effective temperatures (⁠Teff⁠) and secular mean accretion rates (⁠⟨M˙⟩⁠) of 43 cataclysmic variable (CV) white dwarfs, 42 of which were obtained from the combined analysis of their Hubble Space Telescope ultraviolet data with the parallaxes provided by the Early Third Data Release of the Gaia space mission, and one from the white dwarf gravitational redshift. Our results double the number of CV white dwarfs with an accurate mass measurement, bringing the total census to 89 systems. From the study of the mass distribution, we derive ⟨MWD⟩=0.81+0.16/−0.20M⊙⁠, in perfect agreement with previous results, and find no evidence of any evolution of the mass with orbital period. Moreover, we identify five systems with MWD < 0.5M⊙, which are most likely representative of helium-core white dwarfs, showing that these CVs are present in the overall population. We reveal the presence of an anti-correlation between the average accretion rates and the white dwarf masses for the systems below the 2 − 3 h period gap. Since ⟨M˙⟩ reflects the rate of system angular momentum loss, this correlation suggests the presence of an additional mechanism of angular momentum loss that is more efficient at low white dwarf masses. This is the fundamental concept of the recently proposed empirical prescription of consequential angular momentum loss (eCAML) and our results provide observational support for it, although we also highlight how its current recipe needs to be refined to better reproduce the observed scatter in Teff and ⟨M˙⟩⁠, and the presence of helium-core white dwarfs

The Physics of Star Cluster Formation and Evolution

© 2020 Springer-Verlag. The final publication is available at Springer via https://doi.org/10.1007/s11214-020-00689-4.Star clusters form in dense, hierarchically collapsing gas clouds. Bulk kinetic energy is transformed to turbulence with stars forming from cores fed by filaments. In the most compact regions, stellar feedback is least effective in removing the gas and stars may form very efficiently. These are also the regions where, in high-mass clusters, ejecta from some kind of high-mass stars are effectively captured during the formation phase of some of the low mass stars and effectively channeled into the latter to form multiple populations. Star formation epochs in star clusters are generally set by gas flows that determine the abundance of gas in the cluster. We argue that there is likely only one star formation epoch after which clusters remain essentially clear of gas by cluster winds. Collisional dynamics is important in this phase leading to core collapse, expansion and eventual dispersion of every cluster. We review recent developments in the field with a focus on theoretical work.Peer reviewe

Comportamento vegetativo e produtivo da videira e composição da uva em São Joaquim, Santa Catarina

O objetivo deste trabalho foi avaliar o comportamento vegetativo e produtivo das variedades de videira Cabernet Sauvignon, Merlot e Sauvignon Blanc, e a composição da uva em São Joaquim, Santa Catarina. Foram avaliadas plantas de um vinhedo comercial, cultivado em espaldeira, a 1.293 m de altitude, durante os ciclos fenológicos 2005/2006 e 2006/2007. As variáveis meteorológicas, a fenologia, o desenvolvimento do dossel e a composição da uva na colheita foram comparados entre os ciclos. As temperaturas mais amenas influenciaram o ciclo fenológico das variedades Cabernet Sauvignon, Merlot e Sauvignon Blanc, que é mais longo e tardio que nas outras regiões vitícolas do Brasil. Houve influência significativa da precipitação pluvial sobre a maturação da uva, no ciclo 2006/2007. Os índices de desenvolvimento indicam a necessidade de ajuste no manejo do dossel para um maior equilíbrio entre o crescimento vegetativo e a produção. As variedades Cabernet Sauvignon, Merlot e Sauvignon Blanc apresentam elevada qualidade da uva no momento da colheita, sendo adequadas ao cultivo em São Joaquim, SC

The Sudbury Neutrino Observatory

The Sudbury Neutrino Observatory is a second generation water Cherenkov detector designed to determine whether the currently observed solar neutrino deficit is a result of neutrino oscillations. The detector is unique in its use of D2O as a detection medium, permitting it to make a solar model-independent test of the neutrino oscillation hypothesis by comparison of the charged- and neutral-current interaction rates. In this paper the physical properties, construction, and preliminary operation of the Sudbury Neutrino Observatory are described. Data and predicted operating parameters are provided whenever possible.Comment: 58 pages, 12 figures, submitted to Nucl. Inst. Meth. Uses elsart and epsf style files. For additional information about SNO see http://www.sno.phy.queensu.ca . This version has some new reference