40 research outputs found
Factors Affecting European Farmers’Participation in Biodiversity Policies
This article reports the major findings from an interdisciplinary research project that synthesises key insights into farmers’ willingness and ability to co-operate with biodiversity policies. The results of the study are based on an assessment of about 160
publications and research reports from six EU member states and from international comparative research.We developed a conceptual framework to systematically review the
existent literature relevant for our purposes. This framework provides a common structure for analysing farmers’ perspectives regarding the introduction into farming practices of measures relevant to biodiversity. The analysis is coupled and contrasted with a survey of experts. The results presented above suggest that it is important to view support for practices oriented towards biodiversity protection not in a static sense – as a situation determined by one or several influencing factors – but rather as a process marked by interaction. Financial compensation and incentives function as a necessary, though
clearly not sufficient condition in this process
Search for the exotic Resonance in 340GeV/c -Nucleus Interactions
We report on a high statistics search for the resonance in
-nucleus collisions at 340GeV/c. No evidence for this resonance is
found in our data sample which contains 676000 candidates above
background. For the decay channel and the
kinematic range 0.150.9 we find a 3 upper limit for the
production cross section of 3.1 and 3.5 b per nucleon for reactions with
carbon and copper, respectively.Comment: 5 pages, 4 figures, modification of ref. 43 and 4
Correction: “The 5th edition of The World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms” Leukemia. 2022 Jul;36(7):1720–1748
Vegetation ecology of Sekhukhuneland, South Africa: Kirkia wilmsii-Terminalia prunioides Closed Mountain Bushveld
Molecular phylogeny and ultrastructure of two novel parasitic dinoflagellates, Haplozoon gracile sp. nov
A Recurrent Germline Mutation in the 5'UTR of the Androgen Receptor Causes Complete Androgen Insensitivity by Activating Aberrant uORF Translation
A subset of patients with monogenic disorders lacks disease causing mutations in the protein coding region of the corresponding gene. Here we describe a recurrent germline mutation found in two unrelated patients with complete androgen insensitivity syndrome (CAIS) generating an upstream open reading frame (uORF) in the 5’ untranslated region (5’-UTR) of the androgen receptor (AR) gene. We show in patient derived primary genital skin fibroblasts as well as in cell-based reporter assays that this mutation severely impacts AR function by reducing AR protein levels without affecting AR mRNA levels. Importantly, the newly generated uORF translates into a polypeptide and the expression level of this polypeptide inversely correlates with protein translation from the primary ORF of the AR thereby providing a model for AR-5′UTR mediated translational repression. Our findings not only add a hitherto unrecognized genetic cause to complete androgen insensitivity but also underline the importance of 5′UTR mutations affecting uORFs for the pathogenesis of monogenic disorders in general