History effects and pinning regimes in solid vortex matter

We propose a phenomenological model that accounts for the history effects observed in ac susceptibility measurements in YBa2Cu3O7 single crystals [Phys. Rev. Lett. 84, 4200 (2000) and Phys. Rev. Lett. 86, 504 (2001)]. Central to the model is the assumption that the penetrating ac magnetic field modifies the vortex lattice mobility, trapping different robust dynamical states in different regions of the sample. We discuss in detail on the response of the superconductor to an ac magnetic field when the vortex lattice mobility is not uniform inside the sample. We begin with an analytical description for a simple geometry (slab) and then we perform numerical calculations for a strip in a transverse magnetic field which include relaxation effects. In calculations, the vortex system is assumed to coexist in different pinning regimes. The vortex behavior in the regions where the induced current density j has been always below a given threshold (j_c^>) is described by an elastic Campbell-like regime (or a critical state regime with local high critical current density, j_c^>). When the VS is shaken by symmetrical (e.g. sinusoidal) ac fields, the critical current density is modified to j_c^) at regions where vortices have been forced to oscillate by a current density larger than j_c^>. Experimentally, an initial state with high critical current density (j_c^>) can be obtained by zero field cooling, field cooling (with no applied ac field) or by shaking the vortex lattice with an asymmetrical (e.g. sawtooth) field. We compare our calculations with experimental ac susceptibility results in YBa2Cu3O7 single crystals.Comment: 11 pages, 7 figures. To be published in PR

Interaction of vortices in superconductors with kappa close to 2^(-1/2)

Using a perturbative approach to the infinitely degenerate Bogomolnyi vortex state for a superconductor with kappa = 2^(-1/2), T -> T_c, we calculate the interaction of vortices in a superconductor with kappa close to 2^(-1/2). We find, numerically and analytically, that depending on the material the interaction potential between the vortices varies with decreasing kappa from purely repulsive (as in a type-II superconductor) to purely attractive (as in a type-I superconductor) in two different ways: either vortices form a bound state and the distance between them changes gradually from infinity to zero, or this transition occurs in a discontinuous way as a result of a competition between minima at infinity and zero. We study the discontinuous transition between the vortex and Meissner states caused by the non-monotonous vortex interaction and calculate the corresponding magnetization jump.Comment: v1:original submit v2:changed formate of images (gave problems to some) v3:corrected fig v4v6 (was -v4v6) orthographic corrections (and U_lat/int) mismatch v4:more small orthographic corrections v5:converted to revtex4 and bibTex v6:Renamed images to submit to pr

Instanton Contribution to the Quark Form Factor

The nonperturbative effects in the quark form factor are considered in the Wilson loop formalism. The properties of the Wilson loops with cusp singularities are studied taking into account the perturbative and nonperturbative contributions, where the latter are considered within the framework of the instanton liquid model. For the integration path corresponding to this form factor -- the angle with infinite sides -- the explicit expression for the vacuum expectation value of the Wilson operator is found to leading order. The calculations are performed in the weak-field limit for the instanton vacuum contribution and compared with the one- and two-loop order results for the perturbative part. It is shown that the instantons produce the powerlike corrections to the perturbative result, which are comparable in magnitude with the perturbative part at the scale of order of the inverse average instanton size. It is demonstrated that the instanton contributions to the quark form factor are exponentiated to high orders in the small instanton density parameter.Comment: Version coincident with the journal publication. LaTeX, 15 pages, 1 figur

SARS-CoV-2 testing in North Carolina: Racial, ethnic, and geographic disparities

SARS-CoV-2 testing data in North Carolina during the first three months of the state's COVID-19 pandemic were analyzed to determine if there were disparities among intersecting axes of identity including race, Latinx ethnicity, age, urban-rural residence, and residence in a medically underserved area. Demographic and residential data were used to reconstruct patterns of testing metrics (including tests per capita, positive tests per capita, and test positivity rate which is an indicator of sufficient testing) across race-ethnicity groups and urban-rural populations separately. Across the entire sample, 13.1% (38,750 of 295,642) of tests were positive. Within racial-ethnic groups, 11.5% of all tests were positive among non-Latinx (NL) Whites, 22.0% for NL Blacks, and 66.5% for people of Latinx ethnicity. The test positivity rate was higher among people living in rural areas across all racial-ethnic groups. These results suggest that in the first three months of the COVID-19 pandemic, access to COVID-19 testing in North Carolina was not evenly distributed across racial-ethnic groups, especially in Latinx, NL Black and other historically marginalized populations, and further disparities existed within these groups by gender, age, urban-rural status, and residence in a medically underserved area

Strong 3D correlations in vortex system of Bi2212:Pb

The experimental study of magnetic flux penetration under crossed magnetic fields in Bi2212:Pb single crystal performed by magnetooptic technique (MO) reveals remarkable field penetration pattern alteration (flux configuration change) and superconducting current anisotropy enhancement by the in-plane field. The anisotropy increases with the temperature rise up to $T_m = 54 \pm 2 K$. At $T = T_m$ an abrupt change in the flux behavior is found; the correlation between the in-plane magnetic field and the out-of-plane magnetic flux penetration disappears. No correlation is observed for $T > T_m$. The transition temperature $T_m$ does not depend on the magnetic field strength. The observed flux penetration anisotropy is considered as an evidence of a strong 3D - correlation between pancake vortices in different CuO planes at $T < T_m$. This enables understanding of a remarkable pinning observed in Bi2212:Pb at low temperatures.Comment: 8 pages, 9 figure

Well-Posed Initial-Boundary Evolution in General Relativity

Maximally dissipative boundary conditions are applied to the initial-boundary value problem for Einstein's equations in harmonic coordinates to show that it is well-posed for homogeneous boundary data and for boundary data that is small in a linearized sense. The method is implemented as a nonlinear evolution code which satisfies convergence tests in the nonlinear regime and is robustly stable in the weak field regime. A linearized version has been stably matched to a characteristic code to compute the gravitational waveform radiated to infinity.Comment: 5 pages, 6 figures; added another convergence plot to Fig. 2 + minor change

Instanton Corrections to Quark Form Factor at Large Momentum Transfer

Within the Wilson integral formalism, we discuss the structure of nonperturbative corrections to the quark form factor at large momentum transfer analyzing the infrared renormalon and instanton effects. We show that the nonperturbative effects determine the initial value for the perturbative evolution of the quark form factor and attribute their general structure to the renormalon ambiguities of the perturbative series. It is demonstrated that the instanton contributions result in the finite renormalization of the next-to-leading perturbative result and numerically are characterized by a small factor reflecting the diluteness of the QCD vacuum within the instanton liquid model.Comment: Version coincident with the journal publication, 9 pages; REVTe

A drug repurposing screen for whipworms informed by comparative genomics.

Hundreds of millions of people worldwide are infected with the whipworm Trichuris trichiura. Novel treatments are urgently needed as current drugs, such as albendazole, have relatively low efficacy. We have investigated whether drugs approved for other human diseases could be repurposed as novel anti-whipworm drugs. In a previous comparative genomics analysis, we identified 409 drugs approved for human use that we predicted to target parasitic worm proteins. Here we tested these ex vivo by assessing motility of adult worms of Trichuris muris, the murine whipworm, an established model for human whipworm research. We identified 14 compounds with EC50 values of ≤50 μM against T. muris ex vivo, and selected nine for testing in vivo. However, the best worm burden reduction seen in mice was just 19%. The high number of ex vivo hits against T. muris shows that we were successful at predicting parasite proteins that could be targeted by approved drugs. In contrast, the low efficacy of these compounds in mice suggest challenges due to their chemical properties (e.g. lipophilicity, polarity, molecular weight) and pharmacokinetics (e.g. absorption, distribution, metabolism, and excretion) that may (i) promote absorption by the host gastrointestinal tract, thereby reducing availability to the worms embedded in the large intestine, and/or (ii) restrict drug uptake by the worms. This indicates that identifying structural analogues that have reduced absorption by the host, and increased uptake by worms, may be necessary for successful drug development against whipworms

X-ray Spectroscopy and Variability of AGN Detected in the 2 Ms Chandra Deep Field-North Survey

We investigate the nature of the faint X-ray source population through X-ray spectroscopy and variability analyses of 136 AGN detected in the 2 Ms Chandra Deep Field-North survey with > 200 background-subtracted 0.5-8.0 keV counts [F(0.5-8.0 keV)=(1.4-200)e-15 erg cm^{-2} s^{-1}]. Our preliminary spectral analyses yield median spectral parameters of Gamma=1.61 and intrinsic N_H=6.2e21 cm^{-2} (z=1 assumed when no redshift available) when the AGN spectra are fitted with a simple absorbed power-law model. However, considerable spectral complexity is apparent (e.g., reflection, partial covering) and must be taken into account to model the data accurately. Moreover, the choice of spectral model (i.e., free vs. fixed photon index) has a pronounced effect on the derived N_H distribution and, to a lesser extent, the X-ray luminosity distribution. Ten of the 136 AGN (~7%) show significant Fe Kalpha emission-line features with equivalent widths in the range 0.1-1.3 keV. Two of these emission-line AGN could potentially be Compton thick (i.e., Gamma < 1.0 and large Fe Kalpha equivalent width). Finally, we find that 81 (~60%) of the 136 AGN show signs of variability, and that this fraction increases significantly (~80-90%) when better photon statistics are available.Comment: Submitted to Advances in Space Research for New X-ray Results from Clusters of Galaxies and Black Holes (Oct 2002; Houston, TX), eds. C. Done, E.M. Puchnarewicz, M.J. Ward. Requires cospar.sty (6 pgs, 10 figs

Longitudinal intravital imaging of the retina reveals long-term dynamics of immune infiltration and its effects on the glial network in experimental autoimmune uveoretinitis, without evident signs of neuronal dysfunction in the ganglion cell layer

A hallmark of autoimmune retinal inflammation is the infiltration of the retina with cells of the innate and adaptive immune system, leading to detachment of the retinal layers and even to complete loss of the retinal photoreceptor layer. As the only optical system in the organism, the eye enables non-invasive longitudinal imaging studies of these local autoimmune processes and of their effects on the target tissue. Moreover, as a window to the central nervous system (CNS), the eye also reflects general neuroinflammatory processes taking place at various sites within the CNS. Histological studies in murine neuroinflammatory models, such as experimental autoimmune uveoretinitis (EAU) and experimental autoimmune encephalomyelitis, indicate that immune infiltration is initialized by effector CD4(+) T cells, with the innate compartment (neutrophils, macrophages, and monocytes) contributing crucially to tissue degeneration that occurs at later phases of the disease. However, how the immune attack is orchestrated by various immune cell subsets in the retina and how the latter interact with the target tissue under in vivo conditions is still poorly understood. Our study addresses this gap with a novel approach for intravital two-photon microscopy, which enabled us to repeatedly track CD4(+) T cells and LysM phagocytes during the entire course of EAU and to identify a specific radial infiltration pattern of these cells within the inflamed retina, starting from the optic nerve head. In contrast, highly motile [Formula: see text] cells display an opposite radial motility pattern, toward the optic nerve head. These inflammatory processes induce modifications of the microglial network toward an activated morphology, especially around the optic nerve head and main retinal blood vessels, but do not affect the neurons within the ganglion cell layer. Thanks to the new technology, non-invasive correlation of clinical scores of CNS-related pathologies with immune infiltrate behavior and subsequent tissue dysfunction is now possible. Hence, the new approach paves the way for deeper insights into the pathology of neuroinflammatory processes on a cellular basis, over the entire disease course