782 research outputs found
Detection, Surveillance and Treatment of Pre-malignant Gastric Lesions related to Helicobacter pylori Infection
Gastric cancer is the fourth most common cancer and second leading cause of cancer-related
death worldwide. The highest incidences are observed in Eastern Asia, Eastern Europe
and South America, whereas the incidence in Western countries is much lower. For example,
in Japan, the incidence of gastric cancer is approximately 44.1 cases/100 000 persons/year
(world standardized rate, WSR). In comparison, in the Netherlands, the incidence of gastric
cancer is relatively low with approximately 6.9 cases/100 000 persons/year (WSR). The incidence
of gastric cancer is declining, in particular in Western countries. However, the absolute
number of new cases per year increases, due to aging of the world population and expansion
of the population in developing countries with a high gastric cancer incidence.
As symptoms are often absent or non-specific in patients with an early stage of disease,
gastric cancer is usually diagnosed at an advanced stage. In advanced gastric cancer, curative
options are frequently limited and in these cases only palliative treatment can be offered.
During palliative treatment, most responses to chemotherapy are partial and of short duration,
rendering a relatively small effect on survival. Consequently, gastric cancer carries
a poor prognosis, with an overall five-year survival rate of less than 20 percent. In order
to reduce its mortality, detection and intervention in an early stage are essential for gastric cancer prevention.
Gastric cancer is a heterogeneous disease with a complex pathogenesis. Proximal gastric
carcinomas have probably a mixed etiology, partly related to the etiology of distal esophageal
carcinomas and partly to the etiology of distal gastric cancer. The vast majority of distal
gastric malignancies are adenocarcinomas, which are commonly divided into intestinal type
and diffuse (undifferentiated) type carcinomas. Intestinal type gastric carcinomas account
for at least 60 to 75 percent of cancers
Recht op seksuele gezondheid en de rol van de arts
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EHRM 31 januari 2023, Y t. Frankrijk, nr. 76888/17, ECLI:CE:ECHR:2023:0131JUD007688817
EHRMEHRC 2023-0071FdR β Publicaties niet-programma gebonde
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Effective Protection of Fundamental Rights in a pluralist worldCoherent privaatrech
Geen verplichte anticonceptie meer aan personen met een ernstige psychische aandoening
Effective Protection of Fundamental Rights in a pluralist worl
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